The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

URI1  -  URI1, prefoldin-like chaperone

Homo sapiens

Synonyms: C19orf2, FLJ10575, NNX3, PPP1R19, Protein NNX3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C19orf2

  • We previously identified a novel cellular protein, RPB5-mediating protein (RMP), that retains corepressor activity and functionally antagonizes transcriptional modulation via hepatitis B virus X protein [1].
  • The cloning and comprehensive molecular analysis of NNX3 as presented will form the basis for elucidating its function and, conversely, will constitute a marker for Reed-Sternberg cells in Hodgkin disease [2].
  • The expression of human NNX3 was most notable in human skeletal muscle and in ganglion cells and was also evident in human tumors and derived cell lines [2].
  • Surprisingly, NNX3 was immunochemically detected in Reed-Sternberg cells of Hodgkin disease, in parallel with restin, a cytoplasmic protein we previously characterized (J. Delabie et al., 1993, Leuk. Lymphoma 12, 21-26) [2].
  • After experimental induction of a rhinovirus URI, physician 4's airborne dispersal of S. aureus without a surgical mask increased 40- fold; dispersal was significantly reduced when physician 4 wore a mask (P < or = 0.015) [3].

High impact information on C19orf2

  • Using a yeast two-hybrid method, we isolated a putative corepressor, DNA methyltransferase 1-associating protein (DMAP1), which was found to bind to the CC domain of RMP [1].
  • Furthermore, RMP has an inhibitory effect on transcriptional activation by VP16 in the absence of HBx [4].
  • By far-Western blot screening, we cloned a novel gene encoding a 508-amino-acid-residue RPB5-binding protein from a HepG2 cDNA library and designated it RPB5-mediating protein (RMP) [4].
  • Unconventional prefoldin RPB5 interactor (URI), an evolutionary conserved member of the prefoldin family of molecular chaperones, forms a large prefoldin like complex and plays a central role in the regulation of nutrient-sensitive, TOR (target-of-rapamycin)-dependent gene expression programs in yeast [5].
  • Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively) [6].

Chemical compound and disease context of C19orf2


Biological context of C19orf2

  • Human and mouse NNX3 genes are composed of nine exons coding for proteins that are unrelated to any known protein [2].
  • A novel protein, named NNX3, was molecularly characterized by cloning its cDNA, and its gene was mapped to chromosome 19q12 [2].
  • Thus, URI is a component of a signaling pathway that coordinates nutrient availability with gene expression [5].
  • At least one URI was noted in 52% of subjects (99/191) with the NA2/NA2 genotype of the neutrophil-specific FCGR3B gene, compared to 42% (77/181) of those with the NA1/NA2 genotype and 39% (23/59) of those with the NA1/NA1 genotype (P = 0.038) [9].
  • METHODS: We performed a retrospective review of 734 patients with a diagnosis of acute sinusitis (n = 367) or URI (n = 367) at a family practice residency training site over a 3-year period [10].

Anatomical context of C19orf2

  • Putative nuclear targeting signals were predicted, but NNX3 protein and two truncated versions remained localized in the cytoplasm of transfected Cos cells [2].
  • A prospective tympanometric and microbiologic study of 28 pre-schoolchildren was undertaken to better define the effect of acute URI on induction of eustachian tube dysfunction [11].
  • Although colonization of the nasopharynx of well children with Pn or HF was associated with a higher incidence of abnormal middle ear pressure, colonization with Pn or HF during URI did not influence the frequency of tympanogram abnormality [11].
  • The role of SSO was particularly significant in case of pneumonia, URI, urinary tract infections, seizures, gastroenteritis, abdominal pain, infant fever, injuries [12].
  • However, Staph. aureus was found as the sole organism in children with exudate more often than in the children with only URI [13].

Associations of C19orf2 with chemical compounds

  • RESULTS: Twenty-four patients receiving daily or twice-weekly standard therapy with isoniazid (INH, 300 or 900 mg) and rifampin (RMP, 600 mg) were identified; 22 had drug levels evaluated at 2 h [14].
  • A pepstatin A molecule fits into the large substrate-binding cleft between the two domains of RMP in an extended conformation up to the alanine residue at the P2' position [15].
  • Simultaneous administration of PAS granules produced a significant decrease in the absorption of RMP, whereas Na-PAS tablets had no effect [16].
  • The use of ribavirin 5'-phosphate (RMP, 1,2,4-triazole-3-carboxamide riboside 5-monophosphate) as the phosphate donor obviates this difficulty since this triazole heterocycle does not significantly absorb at the wavelengths used to detect most nucleoside analogs [17].
  • Replacement of Trp39 of Rhizomucor pusillus pepsin (RMPP) by Asn or Cys resulted in a marked decrease in the milk-clotting and proteolytic activities [18].

Analytical, diagnostic and therapeutic context of C19orf2

  • In Western blotting and immunoprecipitation, human NNX3 appeared as a doublet of Mr 64K-66K, while mouse NNX3 was a 70-kDa protein, both apparently much larger than the predicted 50 kDa, due in part to a stretch of 16-18 acidic residues hinging two nearly equally sized domains [2].
  • OBJECTIVE: To investigate the contribution of a nasal methicillin-resistant S. aureus (MRSA) carrier (physician 4) who contracted a URI to an outbreak of MRSA infections that involved 8 of 43 patients in a surgical intensive care unit during a 3-week period [3].
  • We obtained pre- and post-season viral serologic studies, biweekly nose and throat viral cultures, daily urinalysis, biweekly telephone follow-up for URI and renal complaints, and clinical assessments as indicated [19].
  • RMP analysis produced hit rates of up to 21%, dependent on the biological activity class, and led to an average approximately 3600-fold improvement over random selection for the activity classes that were used as test cases [20].
  • 45 of these patients were chemotherapy naive (CN-RMP) and 42 had received one prior course of chemotherapy (CP-RMP) [21].


  1. Subcellular localization of RPB5-mediating protein and its putative functional partner. Delgermaa, L., Hayashi, N., Dorjsuren, D., Nomura, T., Thuy, l.e. .T.T., Murakami, S. Mol. Cell. Biol. (2004) [Pubmed]
  2. Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. Van Leuven, F., Torrekens, S., Moechars, D., Hilliker, C., Buellens, M., Bollen, M., Delabie, J. Genomics (1998) [Pubmed]
  3. A cloud adult: the Staphylococcus aureus-virus interaction revisited. Sheretz, R.J., Reagan, D.R., Hampton, K.D., Robertson, K.L., Streed, S.A., Hoen, H.M., Thomas, R., Gwaltney, J.M. Ann. Intern. Med. (1996) [Pubmed]
  4. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Dorjsuren, D., Lin, Y., Wei, W., Yamashita, T., Nomura, T., Hayashi, N., Murakami, S. Mol. Cell. Biol. (1998) [Pubmed]
  5. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Gstaiger, M., Luke, B., Hess, D., Oakeley, E.J., Wirbelauer, C., Blondel, M., Vigneron, M., Peter, M., Krek, W. Science. (2003) [Pubmed]
  6. A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. Williams, J.V., Martino, R., Rabella, N., Otegui, M., Parody, R., Heck, J.M., Crowe, J.E. J. Infect. Dis. (2005) [Pubmed]
  7. Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity. Ohno, M., Yamaguchi, I., Yamamoto, I., Fukuda, T., Yokota, S., Maekura, R., Ito, M., Yamamoto, Y., Ogura, T., Maeda, K., Komuta, K., Igarashi, T., Azuma, J. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2000) [Pubmed]
  8. Abdominal cramp as an adverse effect of travoprost. Lee, Y.C. Am. J. Ophthalmol. (2005) [Pubmed]
  9. Genetic risk factors for infection in patients with early rheumatoid arthritis. Hughes, L.B., Criswell, L.A., Beasley, T.M., Edberg, J.C., Kimberly, R.P., Moreland, L.W., Seldin, M.F., Bridges, S.L. Genes Immun. (2004) [Pubmed]
  10. Criteria used by clinicians to differentiate sinusitis from viral upper respiratory tract infection. Hueston, W.J., Eberlein, C., Johnson, D., Mainous, A.G. The Journal of family practice. (1998) [Pubmed]
  11. Effect of upper respiratory tract infection on eustachian tube ventilatory function in the preschool child. Sanyal, M.A., Henderson, F.W., Stempel, E.C., Collier, A.M., Denny, F.W. J. Pediatr. (1980) [Pubmed]
  12. Short-stay observation in the Pediatric Emergency Room: a 2003-1993 comparison. Guglia, E., Messi, G., Bassanese, S., Norbedo, S., Ronfani, L., Marchi, A.G. Minerva Pediatr. (2006) [Pubmed]
  13. Aetiologic agents of septic sore throat in Thai children. Jayanetra, P., Vorachit, M., Pienthaweechai, K., Pongpanich, B., Niemsiri, S. Southeast Asian J. Trop. Med. Public Health (1978) [Pubmed]
  14. Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients. Kimerling, M.E., Phillips, P., Patterson, P., Hall, M., Robinson, C.A., Dunlap, N.E. Chest (1998) [Pubmed]
  15. Structure of the Rhizomucor miehei aspartic proteinase complexed with the inhibitor pepstatin A at 2.7 A resolution. Yang, J., Quail, J.W. Acta Crystallogr. D Biol. Crystallogr. (1999) [Pubmed]
  16. Mechanism of the inhibitory effect of PAS granules on the absorption of rifampicin: adsorption of rifampicin by an excipient, bentonite. Boman, G., Lundgren, P., Stjernström, G. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  17. A novel non-radioactive method for detection of nucleoside analog phosphorylation by 5'-nucleotidase. Fujitaki, J.M., Nord, L.D., Willis, R.C., Robins, R.K. J. Biochem. Biophys. Methods (1992) [Pubmed]
  18. Site-directed mutagenesis of conserved Trp39 in Rhizomucor pusillus pepsin: possible role of Trp39 in maintaining Tyr75 in the correct orientation for maximizing catalytic activity. Park, Y.N., Aikawa, J., Nishiyama, M., Horinouchi, S., Beppu, T. J. Biochem. (1997) [Pubmed]
  19. Role of respiratory viruses in exacerbations of primary nephrotic syndrome. MacDonald, N.E., Wolfish, N., McLaine, P., Phipps, P., Rossier, E. J. Pediatr. (1986) [Pubmed]
  20. Recursive median partitioning for virtual screening of large databases. Godden, J.W., Furr, J.R., Bajorath, J. Journal of chemical information and computer sciences. (2003) [Pubmed]
  21. Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group. Gregor, A., Lind, M., Newman, H., Grant, R., Hadley, D.M., Barton, T., Osborn, C. J. Neurooncol. (1999) [Pubmed]
WikiGenes - Universities