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Gene Review

GSTF10  -  glutathione S-transferase PHI 10

Arabidopsis thaliana

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Disease relevance of ATGSTF10


High impact information on ATGSTF10

  • Octopine synthase (ocs) elements are a group of promoter elements that have been exploited by plant pathogens to express genes in plants. ocs elements are components of the promoters of certain plant glutathione S-transferase genes and may function as oxidative stress response elements [4].
  • AKIN10 and AKIN11, purified in fusion with glutathione S-transferase, undergo autophosphorylation and phosphorylate a peptide of sucrose phosphate synthase in vitro [5].
  • By contrast, measurements of transcript levels for a gene encoding glutathione S-transferase demonstrated that wound induction of this gene is independent of jasmonate synthesis [6].
  • The genome of Arabidopsis thaliana contains unusual members of the glutathione S-transferase (GST) superfamily with a cysteine in place of a serine at the active site [7].
  • Recombinant glutathione S-transferase fusion protein of PKS11 was inactive in substrate phosphorylation [8].

Biological context of ATGSTF10

  • Two cDNA clones, designated ERD11 and ERD13, isolated from a cDNA library from Arabidopsis thaliana L. plants dehydrated for 1 h were sequenced and characterized [1].
  • GST-ASA1 cleavage by thrombin, as well as site-directed mutagenesis modifications of the Trp allosteric site, inactivated the recombinant protein [9].
  • The TT19 gene was isolated by chromosome walking and a candidate gene approach, and was shown to be a member of the Arabidopsis glutathione S-transferase (GST) gene family [10].
  • The expression of the immediate early genes glutathione S-transferase (GST6) and glucosyltransferase (EIGT) was studied in npr1 mutant and wild-type Arabidopsis plants [11].
  • Transgenic arabidopsis plants were isolated that contained a T-DNA construct in which the promoter of an auxin-inducible glutathione S-transferase (GST) gene from tobacco was fused to the kanamycin resistance (nptII) as well as to the beta-glucuronidase (gusA) reporter gene [12].

Anatomical context of ATGSTF10

  • Using reporter assays in tobacco protoplasts and yeast as well as glutathione-S-transferase (GST) pull-down assays, we demonstrate that short peptide motifs enriched with aromatic and large hydrophobic amino acid (aa) residues embedded in an acidic surrounding (AHA motifs) are essential for transcriptional activity of class A Hsfs [13].
  • Catalytically active recombinant plastid E2 was purified as a glutathione S-transferase fusion protein [14].
  • The sequence was PCR amplified from genomic DNA of S. solfataricus P2 and heterologous gene expression obtained as a fusion to glutathione S-transferase in Escherichia coli, under conditions suitable to reduce the formation of inclusion bodies [15].

Associations of ATGSTF10 with chemical compounds

  • The activities of superoxide dismutase (SOD) and catalase (CAT) increased significantly after 48 h exposure to 1 and 5mg/L of microcystin-RR, but glutathione S-transferase (GST) activity showed no difference compared with the control [16].
  • Characterization of two cDNAs (ERD11 and ERD13) for dehydration-inducible genes that encode putative glutathione S-transferases in Arabidopsis thaliana L [1].
  • Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids [17].
  • Antibodies generated to the GST-CAC1 protein reacted solely with the 38-kD biotin-containing polypeptide of Arabidopsis [3].
  • Crossing GSTF8:luciferase plants with plants harboring an Nah-G construct that degrades salicylic acid did not abolish the response, indicating that the GSTF8 promoter response to R. solani may be mediated by signals other than salicylic acid [18].

Analytical, diagnostic and therapeutic context of ATGSTF10


  1. Characterization of two cDNAs (ERD11 and ERD13) for dehydration-inducible genes that encode putative glutathione S-transferases in Arabidopsis thaliana L. Kiyosue, T., Yamaguchi-Shinozaki, K., Shinozaki, K. FEBS Lett. (1993) [Pubmed]
  2. The rapid induction of glutathione S-transferases AtGSTF2 and AtGSTF6 by avirulent Pseudomonas syringae is the result of combined salicylic acid and ethylene signaling. Lieberherr, D., Wagner, U., Dubuis, P.H., Métraux, J.P., Mauch, F. Plant Cell Physiol. (2003) [Pubmed]
  3. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-coenzyme A carboxylase. Choi, J.K., Yu, F., Wurtele, E.S., Nikolau, B.J. Plant Physiol. (1995) [Pubmed]
  4. Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences. Zhang, B., Chen, W., Foley, R.C., Büttner, M., Singh, K.B. Plant Cell (1995) [Pubmed]
  5. Regulatory interaction of PRL1 WD protein with Arabidopsis SNF1-like protein kinases. Bhalerao, R.P., Salchert, K., Bakó, L., Okrész, L., Szabados, L., Muranaka, T., Machida, Y., Schell, J., Koncz, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Jasmonate is essential for insect defense in Arabidopsis. McConn, M., Creelman, R.A., Bell, E., Mullet, J.E., Browse, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. A Plant Homolog of Animal Chloride Intracellular Channels (CLICs) Generates an Ion Conductance in Heterologous Systems. Elter, A., Hartel, A., Sieben, C., Hertel, B., Fischer-Schliebs, E., Lüttge, U., Moroni, A., Thiel, G. J. Biol. Chem. (2007) [Pubmed]
  8. Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase. Gong, D., Gong, Z., Guo, Y., Chen, X., Zhu, J.K. J. Biol. Chem. (2002) [Pubmed]
  9. Functional expression of Arabidopsis thaliana anthranilate synthase subunit I in Escherichia coli. Bernasconi, P., Walters, E.W., Woodworth, A.R., Siehl, D.L., Stone, T.E., Subramanian, M.V. Plant Physiol. (1994) [Pubmed]
  10. TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis. Kitamura, S., Shikazono, N., Tanaka, A. Plant J. (2004) [Pubmed]
  11. NPR1-independent activation of immediate early salicylic acid-responsive genes in Arabidopsis. Uquillas, C., Letelier, I., Blanco, F., Jordana, X., Holuigue, L. Mol. Plant Microbe Interact. (2004) [Pubmed]
  12. Selection of Arabidopsis mutants overexpressing genes driven by the promoter of an auxin-inducible glutathione S-transferase gene. van der Kop, D.A., Schuyer, M., Pinas, J.E., van der Zaal, B.J., Hooykaas, P.J. Plant Mol. Biol. (1999) [Pubmed]
  13. Characterization of C-terminal domains of Arabidopsis heat stress transcription factors (Hsfs) and identification of a new signature combination of plant class A Hsfs with AHA and NES motifs essential for activator function and intracellular localization. Kotak, S., Port, M., Ganguli, A., Bicker, F., von Koskull-Döring, P. Plant J. (2004) [Pubmed]
  14. Cloning and characterization of the dihydrolipoamide S-acetyltransferase subunit of the plastid pyruvate dehydrogenase complex (E2) from Arabidopsis. Mooney, B.P., Miernyk, J.A., Randall, D.D. Plant Physiol. (1999) [Pubmed]
  15. Identification of a GDP-mannose pyrophosphorylase gene from Sulfolobus solfataricus. Sacchetti, S., Bartolucci, S., Rossi, M., Cannio, R. Gene (2004) [Pubmed]
  16. Responses of antioxidant system in Arabidopsis thaliana suspension cells to the toxicity of microcystin-RR. Yin, L., Huang, J., Huang, W., Li, D., Liu, Y. Toxicon (2005) [Pubmed]
  17. Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids. Smith, A.P., Nourizadeh, S.D., Peer, W.A., Xu, J., Bandyopadhyay, A., Murphy, A.S., Goldsbrough, P.B. Plant J. (2003) [Pubmed]
  18. Early induction of the Arabidopsis GSTF8 promoter by specific strains of the fungal pathogen Rhizoctonia solani. Perl-Treves, R., Foley, R.C., Chen, W., Singh, K.B. Mol. Plant Microbe Interact. (2004) [Pubmed]
  19. Dissection of the ozone-induced calcium signature. Clayton, H., Knight, M.R., Knight, H., McAinsh, M.R., Hetherington, A.M. Plant J. (1999) [Pubmed]
  20. Purification and kinetic studies of recombinant gibberellin dioxygenases. Lester, D.R., Phillips, A., Hedden, P., Andersson, I. BMC Plant Biol. (2005) [Pubmed]
  21. Salicylic acid and NIM1/NPR1-independent gene induction by incompatible Peronospora parasitica in arabidopsis. Rairdan, G.J., Donofrio, N.M., Delaney, T.P. Mol. Plant Microbe Interact. (2001) [Pubmed]
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