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Vdac1  -  voltage-dependent anion channel 1

Rattus norvegicus

Synonyms: Outer mitochondrial membrane protein porin 1, VDAC-1, Voltage-dependent anion-selective channel protein 1, rVDAC1
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Disease relevance of Vdac1


High impact information on Vdac1


Biological context of Vdac1


Anatomical context of Vdac1


Associations of Vdac1 with chemical compounds


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Analytical, diagnostic and therapeutic context of Vdac1


  1. Retinal voltage-dependent anion channel: characterization and cellular localization. Gincel, D., Vardi, N., Shoshan-Barmatz, V. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  2. Hexokinase receptor complex in hepatoma mitochondria: evidence from N,N'-dicyclohexylcarbodiimide-labeling studies for the involvement of the pore-forming protein VDAC. Nakashima, R.A., Mangan, P.S., Colombini, M., Pedersen, P.L. Biochemistry (1986) [Pubmed]
  3. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R.B., Hay, N. Genes Dev. (2001) [Pubmed]
  4. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. Rapizzi, E., Pinton, P., Szabadkai, G., Wieckowski, M.R., Vandecasteele, G., Baird, G., Tuft, R.A., Fogarty, K.E., Rizzuto, R. J. Cell Biol. (2002) [Pubmed]
  5. Phosphorylation of rat brain mitochondrial voltage-dependent anion as a potential tool to control leakage of cytochrome c. Banerjee, J., Ghosh, S. J. Neurochem. (2006) [Pubmed]
  6. Bax increases the pore size of rat brain mitochondrial voltage-dependent anion channel in the presence of tBid. Banerjee, J., Ghosh, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  7. Incorporation in lipid bilayers of a large conductance cationic channel from mitochondrial membranes. Thieffry, M., Chich, J.F., Goldschmidt, D., Henry, J.P. EMBO J. (1988) [Pubmed]
  8. PK 11195 attenuates kainic acid-induced seizures and alterations in peripheral-type benzodiazepine receptor (PBR) protein components in the rat brain. Veenman, L., Leschiner, S., Spanier, I., Weisinger, G., Weizman, A., Gavish, M. J. Neurochem. (2002) [Pubmed]
  9. Mitochondrial VDAC can be phosphorylated by cyclic AMP-dependent protein kinase. Bera, A.K., Ghosh, S., Das, S. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  10. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. Darbandi-Tonkabon, R., Hastings, W.R., Zeng, C.M., Akk, G., Manion, B.D., Bracamontes, J.R., Steinbach, J.H., Mennerick, S.J., Covey, D.F., Evers, A.S. J. Biol. Chem. (2003) [Pubmed]
  11. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Adachi, M., Higuchi, H., Miura, S., Azuma, T., Inokuchi, S., Saito, H., Kato, S., Ishii, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  12. Cerebral distribution of the B-36 VDAC protein in rat, cow and man brain: immunocytochemical study. Ménard, G., Evrard, B., Bureau, M., Trottier, S. Cell. Mol. Biol. (Noisy-le-grand) (1994) [Pubmed]
  13. The intra-mitochondrial cytochrome c distribution varies correlated to the formation of a complex between VDAC and the adenine nucleotide translocase: this affects Bax-dependent cytochrome c release. Vyssokikh, M., Zorova, L., Zorov, D., Heimlich, G., Jürgensmeier, J., Schreiner, D., Brdiczka, D. Biochim. Biophys. Acta (2004) [Pubmed]
  14. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands. Kinnally, K.W., Zorov, D.B., Antonenko, Y.N., Snyder, S.H., McEnery, M.W., Tedeschi, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. Weng, C., Li, Y., Xu, D., Shi, Y., Tang, H. J. Biol. Chem. (2005) [Pubmed]
  16. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Levin, E., Premkumar, A., Veenman, L., Kugler, W., Leschiner, S., Spanier, I., Weisinger, G., Lakomek, M., Weizman, A., Snyder, S.H., Pasternak, G.W., Gavish, M. Biochemistry (2005) [Pubmed]
  17. Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis. Teodoro, J., Rolo, A.P., Oliveira, P.J., Palmeira, C.M. FEBS Lett. (2006) [Pubmed]
  18. All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain. Cesar, M.d.e. .C., Wilson, J.E. Arch. Biochem. Biophys. (2004) [Pubmed]
  19. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Crompton, M., Virji, S., Ward, J.M. Eur. J. Biochem. (1998) [Pubmed]
  20. Voltage-dependent anion-selective channels in cultured smooth muscle cells of the rat aorta. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., Nakamura, M. Comparative biochemistry and physiology. A, Comparative physiology. (1989) [Pubmed]
  21. Molecular basis of morphological changes in mitochondrial membrane accompanying induction of permeability transition, as revealed by immuno-electron microscopy. Terauchi, S., Yamamoto, T., Yamashita, K., Kataoka, M., Terada, H., Shinohara, Y. Mitochondrion (2005) [Pubmed]
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