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Gene Review

SDC3  -  syndecan 3

Homo sapiens

Synonyms: KIAA0468, N-syndecan, SDCN, SYND3, Syndecan-3
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Disease relevance of SDC3


High impact information on SDC3


Biological context of SDC3

  • Additionally, transient transfection experiments suggest a role of human syndecan-3 in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism [6].
  • The similarity of the cloned DNA sequence with that of other mammalian species and the high expression in the nervous system led us to the assumption that human syndecan-3 could perform comparable functions to those described for syndecan-3 in rat and mouse [6].
  • Next, all three nonsynonymous SNPs [T271I (rs2282440, C>T), D245N (rs4949184, C>T), and V150I (rs2491132, C>T)] in the SDC3 gene in control female subjects (BMI < 23, n = 229) and obese female subjects (BMI > 30, n = 245) were genotyped [2].
  • We found that the topographical location of proliferating chondrocytes in developing chick long bones changes with increasing embryonic age and that syndecan-3 gene expression changes in a comparable manner [7].
  • These results indicate that syndecan-3 interferes with the interaction of BMP2 with its receptors, and that this interference results in an inhibition of chondrogenesis [8].

Anatomical context of SDC3

  • In addition, RT-PCR showed the presence of syndecan-3 messenger RNA in endothelial cells extracted from RA and nonrheumatoid synovia [5].
  • When different cell lines were transiently transfected with full-length syndecan-3 cDNA, it was localized to the membrane and induced the formation of long filopodia-like structures, microspikes, and varicosities [6].
  • Consequently, the actin cytoskeleton was re-organized, since actin staining was mostly found in the cellular extensions and at the cell periphery, co-localizing with the syndecan-3 staining [6].
  • Syndecan-3 mRNA is mostly expressed in the nervous system, the adrenal gland, and the spleen [6].
  • Syndecan-3 is a selective regulator of chondrocyte proliferation [7].

Associations of SDC3 with chemical compounds


Physical interactions of SDC3


Regulatory relationships of SDC3


Other interactions of SDC3

  • Syndecan-3 and perlecan expression in tumours was found in an expected distribution pattern [14].
  • Double-staining techniques showed that heparan sulfate was found predominantly at the basal aspect of the endothelium and suggested that syndecan-3 might function as one of the proteoglycans involved in FGF-2 signaling in the endothelium [15].
  • The syndecan-3 antibodies interfered only with FGF-2 mitogenic action, but not that of insulin-like growth factor-1 or parathyroid hormone [7].
  • In addition, we observed different localization of epitope-tagged glypican-2 and syndecan-3 on the surface of N2a cells; the result suggested that they may play different roles in MK-mediated neural function [12].
  • These syndecan-3-rich proliferating chondrocytes lay beneath developing articular chondrocytes rich in their typical matrix protein tenascin-C, resulting in a striking boundary between these two populations of chondrocytes [10].

Analytical, diagnostic and therapeutic context of SDC3


  1. Expression of syndecans, a heparan sulfate proteoglycan, in malignant gliomas: participation of nuclear factor-kappaB in upregulation of syndecan-1 expression. Watanabe, A., Mabuchi, T., Satoh, E., Furuya, K., Zhang, L., Maeda, S., Naganuma, H. J. Neurooncol. (2006) [Pubmed]
  2. Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the korean population. Ha, E., Kim, M.J., Choi, B.K., Rho, J.J., Oh, D.J., Rho, T.H., Kim, K.H., Lee, H.J., Shin, D.H., Yim, S.V., Baik, H.H., Chung, J.H., Kim, J.W. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  3. Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Pfander, D., Swoboda, B., Kirsch, T. Am. J. Pathol. (2001) [Pubmed]
  4. Heparan sulfate proteoglycan expression in chronic cholestatic human liver diseases. Roskams, T., Rosenbaum, J., De Vos, R., David, G., Desmet, V. Hepatology (1996) [Pubmed]
  5. Induction of a CXCL8 binding site on endothelial syndecan-3 in rheumatoid synovium. Patterson, A.M., Gardner, L., Shaw, J., David, G., Loreau, E., Aguilar, L., Ashton, B.A., Middleton, J. Arthritis Rheum. (2005) [Pubmed]
  6. Cloning and characterization of human syndecan-3. Berndt, C., Casaroli-Marano, R.P., Vilaró, S., Reina, M. J. Cell. Biochem. (2001) [Pubmed]
  7. Syndecan-3 is a selective regulator of chondrocyte proliferation. Kirsch, T., Koyama, E., Liu, M., Golub, E.E., Pacifici, M. J. Biol. Chem. (2002) [Pubmed]
  8. Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation. Fisher, M.C., Li, Y., Seghatoleslami, M.R., Dealy, C.N., Kosher, R.A. Matrix Biol. (2006) [Pubmed]
  9. Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. Asundi, V.K., Carey, D.J. J. Biol. Chem. (1995) [Pubmed]
  10. Syndecan-3 and the control of chondrocyte proliferation during endochondral ossification. Shimazu, A., Nah, H.D., Kirsch, T., Koyama, E., Leatherman, J.L., Golden, E.B., Kosher, R.A., Pacifici, M. Exp. Cell Res. (1996) [Pubmed]
  11. Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. Asundi, V.K., Carey, D.J. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  12. Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Kurosawa, N., Chen, G.Y., Kadomatsu, K., Ikematsu, S., Sakuma, S., Muramatsu, T. Glycoconj. J. (2001) [Pubmed]
  13. Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. Erdman, R., Stahl, R.C., Rothblum, K., Chernousov, M.A., Carey, D.J. J. Biol. Chem. (2002) [Pubmed]
  14. Heparan sulphate proteoglycan expression in human primary liver tumours. Roskams, T., De Vos, R., David, G., Van Damme, B., Desmet, V. J. Pathol. (1998) [Pubmed]
  15. Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium. Whitworth, M.K., Backen, A.C., Clamp, A.R., Wilson, G., McVey, R., Friedl, A., Rapraeger, A.C., David, G., McGown, A., Slade, R.J., Gallagher, J.T., Jayson, G.C. Clin. Cancer Res. (2005) [Pubmed]
  16. Mapping heparanase expression in the spinal cord of adult rats. Zhang, Y., Yeung, M.N., Liu, J., Chau, C.H., Chan, Y.S., Shum, D.K. J. Comp. Neurol. (2006) [Pubmed]
  17. Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue. Cluff, A.H., Byström, B., Klimaviciute, A., Dahlqvist, C., Cebers, G., Malmström, A., Ekman-Ordeberg, G. Reprod. Biol. Endocrinol. (2006) [Pubmed]
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