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Gene Review

Sdc3  -  syndecan 3

Mus musculus

Synonyms: Kiaa0468, SYND3, Synd3, Syndecan-3, mKIAA0468, ...
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Disease relevance of Sdc3


Psychiatry related information on Sdc3


High impact information on Sdc3


Biological context of Sdc3


Anatomical context of Sdc3

  • Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration [11].
  • Additionally, we took advantage of the fact that syndecan-3 facilitation of AgRP is limited to when it is bound to the cell membrane [7].
  • These results demonstrate that syndecan-3 expression is down-regulated during differentiation and the level of expression of membrane-bound heparan sulfate on myoblast surface is critical for fine modulation of responsiveness to FGF-2 [8].
  • Syndecan-3 is transiently expressed in developing limb bud and absent in adult skeletal muscle [8].
  • Syndecan-3 is a member of a family of transmembrane proteoglycans that posses highly homologous cytoplasmic and transmembrane domains and function as extracellular matrix receptors and low-affinity receptors for signaling molecules such as basic fibroblasts growth factor (FGF-2) [8].

Associations of Sdc3 with chemical compounds

  • Context: Very recently the unforeseen role of syndecan 3 (SDC3), a family of membrane-bound heparin sulfate proteoglycans, in the regulation of energy balance has been discovered in the Sdc3 null female mice [12].
  • The resulting inhibition of syndecan-3 expression caused accelerated skeletal muscle differentiation, as determined by expression of creatine kinase and myosin and myoblast fusion [8].

Physical interactions of Sdc3


Other interactions of Sdc3


Analytical, diagnostic and therapeutic context of Sdc3


  1. Transgenic expression of syndecan-1 uncovers a physiological control of feeding behavior by syndecan-3. Reizes, O., Lincecum, J., Wang, Z., Goldberger, O., Huang, L., Kaksonen, M., Ahima, R., Hinkes, M.T., Barsh, G.S., Rauvala, H., Bernfield, M. Cell (2001) [Pubmed]
  2. Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Cornelison, D.D., Wilcox-Adelman, S.A., Goetinck, P.F., Rauvala, H., Rapraeger, A.C., Olwin, B.B. Genes Dev. (2004) [Pubmed]
  3. Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling. Finsen, A.V., Woldbaek, P.R., Li, J., Wu, J., Lyberg, T., Tønnessen, T., Christensen, G. Physiol. Genomics (2004) [Pubmed]
  4. Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. Strader, A.D., Reizes, O., Woods, S.C., Benoit, S.C., Seeley, R.J. J. Clin. Invest. (2004) [Pubmed]
  5. Herpes simplex virus 1 (HSV-1) strain HSZP glycoprotein B gene: comparison of mutations among strains differing in virulence. Kosovský, J., Vojvodová, A., Oravcová, I., Kúdelová, M., Matis, J., Rajcáni, J. Virus Genes (2000) [Pubmed]
  6. Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. Spring, J., Goldberger, O.A., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Bernfield, M. Genomics (1994) [Pubmed]
  7. Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway. Reizes, O., Benoit, S.C., Strader, A.D., Clegg, D.J., Akunuru, S., Seeley, R.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  8. Antisense inhibition of syndecan-3 expression during skeletal muscle differentiation accelerates myogenesis through a basic fibroblast growth factor-dependent mechanism. Fuentealba, L., Carey, D.J., Brandan, E. J. Biol. Chem. (1999) [Pubmed]
  9. Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation. Casar, J.C., Cabello-Verrugio, C., Olguin, H., Aldunate, R., Inestrosa, N.C., Brandan, E. J. Cell. Sci. (2004) [Pubmed]
  10. Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory. Kaksonen, M., Pavlov, I., Võikar, V., Lauri, S.E., Hienola, A., Riekki, R., Lakso, M., Taira, T., Rauvala, H. Mol. Cell. Neurosci. (2002) [Pubmed]
  11. Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Cornelison, D.D., Filla, M.S., Stanley, H.M., Rapraeger, A.C., Olwin, B.B. Dev. Biol. (2001) [Pubmed]
  12. Positive association of obesity with single nucleotide polymorphisms of syndecan 3 in the korean population. Ha, E., Kim, M.J., Choi, B.K., Rho, J.J., Oh, D.J., Rho, T.H., Kim, K.H., Lee, H.J., Shin, D.H., Yim, S.V., Baik, H.H., Chung, J.H., Kim, J.W. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  13. Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Hikake, T., Mori, T., Iseki, K., Hagino, S., Zhang, Y., Takagi, H., Yokoya, S., Wanaka, A. Anat. Embryol. (2003) [Pubmed]
  14. Effects of targeted overexpression of pleiotrophin on postnatal bone development. Tare, R.S., Oreffo, R.O., Sato, K., Rauvala, H., Clarke, N.M., Roach, H.I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Divide, accumulate, differentiate: cell condensation in skeletal development revisited. Hall, B.K., Miyake, T. Int. J. Dev. Biol. (1995) [Pubmed]
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