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MeSH Review

Follicular Atresia

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Disease relevance of Follicular Atresia


High impact information on Follicular Atresia


Biological context of Follicular Atresia


Anatomical context of Follicular Atresia


Associations of Follicular Atresia with chemical compounds


Gene context of Follicular Atresia

  • In contrast, follicular atresia is associated with a decrease and a large increase in levels of IGFBP-3 and IGFBPs less than 40 kDa, respectively [21].
  • Because androgens enhance recruitment of primordial follicles into the growth pool and cause atresia of late antral follicles, the inappropriately high level of AR probably is related to the follicular atresia and to the early exhaustion of follicles in BERKO mice [22].
  • Syndecan-4 expression is associated with follicular atresia in mouse ovary [23].
  • The data suggest that a leptin deficiency in mice is associated with impaired folliculogenesis, which results in increased follicular atresia [24].
  • Follicular atresia is associated with greater activity of IGFBP-2, -4, -5, and greater concentrations of P4 in follicles, whereas growing dominant and persistent follicles contained greater concentrations of E2, androstenedione (A4), and less IGFBP-2 activity than follicles of other classes [25].

Analytical, diagnostic and therapeutic context of Follicular Atresia


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  3. Cleavage of cytoskeletal proteins by caspases during ovarian cell death: evidence that cell-free systems do not always mimic apoptotic events in intact cells. Maravei, D.V., Trbovich, A.M., Perez, G.I., Tilly, K.I., Banach, D., Talanian, R.V., Wong, W.W., Tilly, J.L. Cell Death Differ. (1997) [Pubmed]
  4. Ovarian toxicity of cyclophosphamide alone and in combination with ovarian irradiation in the rat. Jarrell, J., Lai, E.V., Barr, R., McMahon, A., Belbeck, L., O'Connell, G. Cancer Res. (1987) [Pubmed]
  5. Preoviposition activation of cathepsin-like proteinases in degenerating ovarian follicles of the mosquito Culex pipiens pallens. Uchida, K., Ohmori, D., Ueno, T., Nishizuka, M., Eshita, Y., Fukunaga, A., Kominami, E. Dev. Biol. (2001) [Pubmed]
  6. Clusterin protects granulosa cells from apoptotic cell death during follicular atresia. Zwain, I., Amato, P. Exp. Cell Res. (2000) [Pubmed]
  7. Progesterone promotes oocyte maturation, but not ovulation, in nonhuman primate follicles without a gonadotropin surge. Borman, S.M., Chaffin, C.L., Schwinof, K.M., Stouffer, R.L., Zelinski-Wooten, M.B. Biol. Reprod. (2004) [Pubmed]
  8. Caspase-3 in the rat ovary: localization and possible role in follicular atresia and luteal regression. Boone, D.L., Tsang, B.K. Biol. Reprod. (1998) [Pubmed]
  9. The effects of melatonin and hypothyroidism on estradiol and gonadotropin levels in female Syrian hamsters. Vriend, J., Bertalanffy, F.D., Ralcewicz, T.A. Biol. Reprod. (1987) [Pubmed]
  10. Effect of alterations in pulsatile luteinizing hormone release on ovarian follicular atresia and steroid secretion on diestrus 1 in the rat estrous cycle. Devorshak-Harvey, E., Peluso, J.J., Bona-Gallo, A., Gallo, R.V. Biol. Reprod. (1985) [Pubmed]
  11. Aspects of cellular proliferation during follicular atresia in the dog ovary. Spanel-Borowski, K., Trepel, F., Schick, P., Pilgrim, C. Cell Tissue Res. (1981) [Pubmed]
  12. Temporal changes in inhibin, steroid hormones, and steroidogenic enzymes during induced follicular atresia in the hypophysectomized cyclic hamster. Otsuka, M., Kishi, H., Arai, K., Watanabe, G., Taya, K., Greenwald, G.S. Biol. Reprod. (1997) [Pubmed]
  13. Chronology of events accompanying follicular atresia in hypophysectomized ewes. Changes in levels of steroidogenic enzymes, connexin 43, insulin-like growth factor II/mannose 6 phosphate receptor, extracellular matrix components, and matrix metalloproteinases. Huet, C., Monget, P., Pisselet, C., Hennequet, C., Locatelli, A., Monniaux, D. Biol. Reprod. (1998) [Pubmed]
  14. Elimination of atretic follicles from the mouse ovary: a TEM and immunohistochemical study in mice. Inoue, S., Watanabe, H., Saito, H., Hiroi, M., Tonosaki, A. J. Anat. (2000) [Pubmed]
  15. Lectin staining studies on follicular atresia in house rat (Rattus rattus). Sharma, R.K., Guraya, S.S. Acta morphologica Hungarica. (1992) [Pubmed]
  16. The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. McNatty, K.P., Makris, A., DeGrazia, C., Osathanondh, R., Ryan, K.J. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  17. Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Billig, H., Furuta, I., Hsueh, A.J. Endocrinology (1993) [Pubmed]
  18. Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. Hughes, F.M., Gorospe, W.C. Endocrinology (1991) [Pubmed]
  19. Evidence that cocaine- and amphetamine-regulated transcript is a novel intraovarian regulator of follicular atresia. Kobayashi, Y., Jimenez-Krassel, F., Li, Q., Yao, J., Huang, R., Ireland, J.J., Coussens, P.M., Smith, G.W. Endocrinology (2004) [Pubmed]
  20. Tissue-type plasminogen activator in rat oocytes: expression during the periovulatory period, after fertilization, and during follicular atresia. Bicsak, T.A., Cajander, S.B., Peng, X.R., Ny, T., LaPolt, P.S., Lu, J.K., Kristensen, P., Tsafriri, A., Hsueh, A.J. Endocrinology (1989) [Pubmed]
  21. Proteolytic activity is involved in changes in intrafollicular insulin-like growth factor-binding protein levels during growth and atresia of ovine ovarian follicles. Besnard, N., Pisselet, C., Zapf, J., Hornebeck, W., Monniaux, D., Monget, P. Endocrinology (1996) [Pubmed]
  22. A role for the androgen receptor in follicular atresia of estrogen receptor beta knockout mouse ovary. Cheng, G., Weihua, Z., Mäkinen, S., Mäkelä, S., Saji, S., Warner, M., Gustafsson, J.A., Hovatta, O. Biol. Reprod. (2002) [Pubmed]
  23. Syndecan-4 expression is associated with follicular atresia in mouse ovary. Ishiguro, K., Kojima, T., Taguchi, O., Saito, H., Muramatsu, T., Kadomatsu, K. Histochem. Cell Biol. (1999) [Pubmed]
  24. Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice. Hamm, M.L., Bhat, G.K., Thompson, W.E., Mann, D.R. Biol. Reprod. (2004) [Pubmed]
  25. Frequency of luteinizing hormone pulses in cattle influences duration of persistence of dominant ovarian follicles, follicular fluid concentrations of steroids, and activity of insulin-like growth factor binding proteins. Kojima, F.N., Bergfeld, E.G., Wehrman, M.E., Cupp, A.S., Fike, K.E., Mariscal-Aguayo, D.V., Sanchez-Torres, T., Garcia-Winder, M., Clopton, D.T., Roberts, A.J., Kinder, J.E. Anim. Reprod. Sci. (2003) [Pubmed]
  26. Oxygen consumption by rat oocytes and cumulus cells during induced atresia. Magnusson, C., Bar Ami, S., Braw, R., Tsafriri, A. J. Reprod. Fertil. (1983) [Pubmed]
  27. Immunolocalization of transforming growth factor-beta1 during follicular development and atresia in the mouse ovary. Christopher, B. Endocr. J. (2000) [Pubmed]
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