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MeSH Review

Mice, Inbred MRL lpr

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Disease relevance of Mice, Inbred MRL lpr


High impact information on Mice, Inbred MRL lpr

  • MRL/lpr mice are particularly severely affected, and they develop a syndrome that is serologically and pathologically similar to human systemic lupus erythematosus (SLE) [5].
  • Here we examine the use of inhibitors of phosphoinositide 3-kinase (PI3K) gamma, a lipid kinase that regulates inflammation, in the MRL-lpr mouse model of SLE [6].
  • An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model [7].
  • Spleen and peritoneal cells from MRL/lpr mice also produced significantly more nitric oxide (NO) than those from the control mice when cultured with interferon (IFN) gamma and lipopolysaccharide (LPS) in vitro [4].
  • It is striking that cells from MRL/lpr mice produced high concentrations of NO when cultured cells from MRL/+ or BALB/c mice [4].

Chemical compound and disease context of Mice, Inbred MRL lpr


Biological context of Mice, Inbred MRL lpr


Anatomical context of Mice, Inbred MRL lpr


Associations of Mice, Inbred MRL lpr with chemical compounds

  • Moreover, these alterations in host defense, including survival in response to lethal infection, could be ameliorated in MRL/lpr mice by the parenteral administration of a monoclonal antibody that neutralizes the activity of TGF-beta [23].
  • RESULTS: Diffuse proliferative GN, with deposition of IgG and C3, developed in both FcRgamma(-/-) and FcRgamma(+) MRL/lpr mice [24].
  • Second, cyclosporin A, which ameliorates GN in MRL/lpr mice despite autoantibody production, was found to reduce serum IgG3 and mRNA levels, associated with the revision of cationic shift of the serum IgG3 spectrotype seen in isoelectric focusing [25].
  • Because dexamethasone (Dex) alters Ia antigen expression and suppresses cytokine generation, the authors prophylactically treated MRL-lpr mice and investigated the relative importance of these molecules in inducing renal injury [26].
  • MRL/lpr mice fed a low-fat, calorically restricted diet from 5 months of age to death lived longer than mice which were fed ad libitum a cholesterol-containing, high-fat diet [10].

Gene context of Mice, Inbred MRL lpr


Analytical, diagnostic and therapeutic context of Mice, Inbred MRL lpr


  1. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Sun, Y., Chen, H.M., Subudhi, S.K., Chen, J., Koka, R., Chen, L., Fu, Y.X. Nat. Med. (2002) [Pubmed]
  2. Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus. Gutierrez-Ramos, J.C., Andreu, J.L., Revilla, Y., Viñuela, E., Martinez, C. Nature (1990) [Pubmed]
  3. Reduction of lupus nephritis in MRL/lpr mice by a bacterial superantigen treatment. Kim, C., Siminovitch, K.A., Ochi, A. J. Exp. Med. (1991) [Pubmed]
  4. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. Huang, F.P., Feng, G.J., Lindop, G., Stott, D.I., Liew, F.Y. J. Exp. Med. (1996) [Pubmed]
  5. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Cohen, P.L., Eisenberg, R.A. Annu. Rev. Immunol. (1991) [Pubmed]
  6. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Barber, D.F., Bartolomé, A., Hernandez, C., Flores, J.M., Redondo, C., Fernandez-Arias, C., Camps, M., Rückle, T., Schwarz, M.K., Rodríguez, S., Martinez-A, C., Balomenos, D., Rommel, C., Carrera, A.C. Nat. Med. (2005) [Pubmed]
  7. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. Gong, J.H., Ratkay, L.G., Waterfield, J.D., Clark-Lewis, I. J. Exp. Med. (1997) [Pubmed]
  8. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. Sekine, H., Reilly, C.M., Molano, I.D., Garnier, G., Circolo, A., Ruiz, P., Holers, V.M., Boackle, S.A., Gilkeson, G.S. J. Immunol. (2001) [Pubmed]
  9. Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice. Sadanaga, A., Nakashima, H., Masutani, K., Miyake, K., Shimizu, S., Igawa, T., Sugiyama, N., Niiro, H., Hirakata, H., Harada, M. Arthritis Rheum. (2005) [Pubmed]
  10. Effects of nutrition on disease and life span. I. Immune responses, cardiovascular pathology, and life span in MRL mice. Mark, D.A., Alonso, D.R., Quimby, F., Thaler, H.T., Kim, Y.T., Fernandes, G., Good, R.A., Weksler, M.E. Am. J. Pathol. (1984) [Pubmed]
  11. Cyclosporine therapy suppresses ocular and lacrimal gland disease in MRL/Mp-lpr/lpr mice. Jabs, D.A., Lee, B., Burek, C.L., Saboori, A.M., Prendergast, R.A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  12. Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome. Zoukhri, D., Kublin, C.L. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  13. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. Jevnikar, A.M., Grusby, M.J., Glimcher, L.H. J. Exp. Med. (1994) [Pubmed]
  14. Unexpectedly high occurrence of catalytic antibodies in MRL/lpr and SJL mice immunized with a transition-state analog: is there a linkage to autoimmunity? Tawfik, D.S., Chap, R., Green, B.S., Sela, M., Eshhar, Z. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. Rieux-Laucat, F., Le Deist, F., Fischer, A. Cell Death Differ. (2003) [Pubmed]
  16. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. Bossu, P., Singer, G.G., Andres, P., Ettinger, R., Marshak-Rothstein, A., Abbas, A.K. J. Immunol. (1993) [Pubmed]
  17. Anti-Sm B cell differentiation in Ig transgenic MRL/Mp-lpr/lpr mice: altered differentiation and an accelerated response. Santulli-Marotto, S., Qian, Y., Ferguson, S., Clarke, S.H. J. Immunol. (2001) [Pubmed]
  18. Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. Li, Y., Li, H., Ni, D., Weigert, M. J. Exp. Med. (2002) [Pubmed]
  19. Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4. Jabs, D.A., Prendergast, R.A. J. Exp. Med. (1987) [Pubmed]
  20. Spontaneous production of tumor necrosis factor alpha by Kupffer cells of MRL/lpr mice. Magilavy, D.B., Rothstein, J.L. J. Exp. Med. (1988) [Pubmed]
  21. gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6. Wang, X.J., Taga, T., Yoshida, K., Saito, M., Kishimoto, T., Kikutani, H. Blood (1998) [Pubmed]
  22. Treatment of intractable autoimmune diseases in MRL/lpr mice using a new strategy for allogeneic bone marrow transplantation. Kushida, T., Inaba, M., Takeuchi, K., Sugiura, K., Ogawa, R., Ikehara, S. Blood (2000) [Pubmed]
  23. Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. Lowrance, J.H., O'Sullivan, F.X., Caver, T.E., Waegell, W., Gresham, H.D. J. Exp. Med. (1994) [Pubmed]
  24. Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Matsumoto, K., Watanabe, N., Akikusa, B., Kurasawa, K., Matsumura, R., Saito, Y., Iwamoto, I., Saito, T. Arthritis Rheum. (2003) [Pubmed]
  25. IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis. Takahashi, S., Nose, M., Sasaki, J., Yamamoto, T., Kyogoku, M. J. Immunol. (1991) [Pubmed]
  26. Dexamethasone prevents autoimmune nephritis and reduces renal expression of Ia but not costimulatory signals. Jevnikar, A.M., Singer, G.G., Brennan, D.C., Xu, H.W., Kelley, V.R. Am. J. Pathol. (1992) [Pubmed]
  27. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. Balomenos, D., Rumold, R., Theofilopoulos, A.N. J. Clin. Invest. (1998) [Pubmed]
  28. Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice. Hasegawa, H., Kohno, M., Sasaki, M., Inoue, A., Ito, M.R., Terada, M., Hieshima, K., Maruyama, H., Miyazaki, J., Yoshie, O., Nose, M., Fujita, S. Arthritis Rheum. (2003) [Pubmed]
  29. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. Christianson, G.J., Blankenburg, R.L., Duffy, T.M., Panka, D., Roths, J.B., Marshak-Rothstein, A., Roopenian, D.C. J. Immunol. (1996) [Pubmed]
  30. Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. Pérez de Lema, G., Maier, H., Nieto, E., Vielhauer, V., Luckow, B., Mampaso, F., Schlöndorff, D. J. Am. Soc. Nephrol. (2001) [Pubmed]
  31. Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide. Marino, M., Ruvo, M., De Falco, S., Fassina, G. Nat. Biotechnol. (2000) [Pubmed]
  32. Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction. Elkon, K.B., Hines, J.J., Chu, J.L., Parnassa, A. J. Immunol. (1990) [Pubmed]
  33. Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Zoukhri, D., Hodges, R.R., Byon, D., Kublin, C.L. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  34. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Koh, D.R., Ho, A., Rahemtulla, A., Fung-Leung, W.P., Griesser, H., Mak, T.W. Eur. J. Immunol. (1995) [Pubmed]
  35. Colony stimulating factor-1 in the induction of lupus nephritis. Bloom, R.D., Florquin, S., Singer, G.G., Brennan, D.C., Kelley, V.R. Kidney Int. (1993) [Pubmed]
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