The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Banks

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Blood Banks

  • Keratin 8 and 18 variants in 17 of 467 liver disease explants and 2 of 349 blood bank controls were previously reported in 5 analyzed exonic regions [1].
  • Soluble and insoluble fractions of Triton X-100 extracts of RA and normal synovial tissue, and normal spleen and placenta, were immunoblotted with sera from 27 patients with recent-onset RA, 13 autoimmune disease control subjects, and 13 blood bank control donors [2].
  • A newly available dried concentrate of antihemophilic factor (Profilate, Abbott Laboratories) was compared with standard, blood-bank prepared cryoprecipitate in the control of bleeding in a patient with von Willebrand's disease [3].
  • By a competitive inhibition ELISA, antiId 3-17 detects a cross-reactive idiotype (CRI) expressed in 18 of 50 (36%) of the sera of patients with BP, but in the sera of only 1 of 50 (2%) normal blood bank controls (p less than 0.001, Fisher's exact test) and 1 of 12 (8%) patients with pemphigus (p = 0.005) [4].
  • Evaluation of the INNO-LIA HTLV I/II assay for confirmation of human T-cell leukemia virus-reactive sera in blood bank donations [5].

High impact information on Blood Banks

  • METHODS: The 11 patients were identified by active surveillance by the medical directors of blood banks (3 patients), hematologists (6), and the manufacturer of clopidogrel (2) [6].
  • Sephadex G-50 Fine gel-exclusion chromatography of an extract of outdated blood bank platelets revealed two hEGF/UG components, one of which eluted in the void volume, and the other of which coeluted with purified standard hEGF/UG [7].
  • Comparing a new consecutive series of IDC patients (n = 41) and healthy blood bank controls (n = 53), we confirmed an increase of DR4 antigen frequency in patients (49% versus 21%, p less than 0.005) [8].
  • We examined the feasibility of a community blood bank granulocyte transfusion program utilizing community donors stimulated with a single-dose regimen of subcutaneous granulocyte colony-stimulating factor (G-CSF) plus oral dexamethasone [9].
  • There was no heightened vWF fragmentation in blood-bank cryoprecipitate prepared from platelet-poor, single-donor plasma; in contrast, there was a marked degree of fragmentation in cryoprecipitate prepared from pooled plasmapheresis plasma representing the starting fraction for the production of commercial concentrates [10].

Chemical compound and disease context of Blood Banks


Biological context of Blood Banks


Anatomical context of Blood Banks

  • Using the standardized assay, we found that tPA antigen concentrations in 16 blood bank plasmas are equivalent to 3.7 to 20 ng of 60 kd tPA/mL [20].
  • This study assessed two major plasma membrane glycoproteins (GP Ib and GP IIb), an alpha-granule membrane protein (GMP-140), and the concentration of platelet membrane microparticles in cell-free plasma during routine hospital blood bank platelet storage [21].
  • Studies of factors regulating the ageing of human erythrocytes. II. Metabolic depletion of erythrocytes is not accompanied by a decrease of their sialic acid content during blood bank storage [22].
  • Hospital blood bank facilities and randomly selected volunteers were used for HCB analyses in serum (n = 100) and cerumen (n = 25) [23].
  • PHA-stimulated peripheral lymphocytes from six healthy adults consisting of four family members of an adult T-cell leukemia (ATL) patient and two blood bank donors, seropositive to ATL-associated antigens (ATLA), were all positive for the expression of ATLA and ATL-associated virus (ATLV) [24].

Associations of Blood Banks with chemical compounds

  • To explore this relationship in more detail, we have studied blood stored in citrate-phosphate-dextrose-adenine under blood bank conditions because, in this system, vesiculation occurs slowly [25].
  • The described method for quantifying serotonin is convenient enough for routine use in blood banks [26].
  • Once the true nature of the serum panagglutinins was determined, blood bank reagents free of thimerosol were used, and no further serologic problems were encountered [27].
  • These experiments have detected various changes in viability markers in platelets that are stored under actual blood bank conditions and indicate that the accumulation of lactate is not totally responsible for the toxic inhibition of platelet performance that is found upon storage at 22 C [28].
  • No previous experiments were done with CPD-adenine (0.25 mM) using a design which would give statistical proof of the optimal concentration of inosine needed for maintenance of normal hemoglobin function (2,3-DPG) for five weeks of blood bank storage [29].

Gene context of Blood Banks

  • STUDY DESIGN AND METHODS: To evaluate the quality of stored platelet concentrates, the cell surface expression of specific activation-dependent antigens (CD62 and lysosome-associated membrane proteins 1 and 2 [LAMP-1, LAMP-2]) on platelets stored in a hospital blood bank over a 7-day period was examined [30].
  • In conclusion, the prevalence of CD in our blood bank population was lower than that reported in other similar studies, but the new test for anti-tTG showed a good sensitivity and reliability, and, therefore, it can be proposed as a first-level test in screening for CD in selected populations such as subjects with hypertransaminasemia [31].
  • RESULTS: The mean OD and 3 SD of the 62 normal blood bank donors for anti-SAA was 0.411 +/- 0.577 [32].
  • Factors such as ABO match and platelet age are related to circumstances potentially under the control of the blood bank physician and therefore may permit circumvention by an active transfusion service [33].
  • In an ongoing study of the changes that occur in platelet concentrates during storage, we investigated two 28-26-Kd proteins designated SP-1 and SP-2, respectively, which increase markedly during blood-bank storage of platelet concentrates at room temperature [34].

Analytical, diagnostic and therapeutic context of Blood Banks


  1. Keratins as susceptibility genes for end-stage liver disease. Ku, N.O., Lim, J.K., Krams, S.M., Esquivel, C.O., Keeffe, E.B., Wright, T.L., Parry, D.A., Omary, M.B. Gastroenterology (2005) [Pubmed]
  2. Antibodies to synovial antigens in recent-onset rheumatoid arthritis. McColl, G.J., Cram, D.S., Harrison, L.C. Arthritis Rheum. (1995) [Pubmed]
  3. Failure of AHF concentration to control bleeding in von Willebrand's disease. Green, D., Potter, E.V. Am. J. Med. (1976) [Pubmed]
  4. Detection of cross-reactive idiotypes in the serum of patients with bullous pemphigoid. Rico, M.J., White, L.D., Bartow, S., Hall, R.P. J. Invest. Dermatol. (1991) [Pubmed]
  5. Evaluation of the INNO-LIA HTLV I/II assay for confirmation of human T-cell leukemia virus-reactive sera in blood bank donations. Sabino, E.C., Zrein, M., Taborda, C.P., Otani, M.M., Ribeiro-Dos-Santos, G., Sáez-Alquézar, A. J. Clin. Microbiol. (1999) [Pubmed]
  6. Thrombotic thrombocytopenic purpura associated with clopidogrel. Bennett, C.L., Connors, J.M., Carwile, J.M., Moake, J.L., Bell, W.R., Tarantolo, S.R., McCarthy, L.J., Sarode, R., Hatfield, A.J., Feldman, M.D., Davidson, C.J., Tsai, H.M. N. Engl. J. Med. (2000) [Pubmed]
  7. Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets. Oka, Y., Orth, D.N. J. Clin. Invest. (1983) [Pubmed]
  8. HLA class II (DR and DQ) antigen associations in idiopathic dilated cardiomyopathy. Validation study and meta-analysis of published HLA association studies. Carlquist, J.F., Menlove, R.L., Murray, M.B., O'Connell, J.B., Anderson, J.L. Circulation (1991) [Pubmed]
  9. Phase I/II trial of neutrophil transfusions from donors stimulated with G-CSF and dexamethasone for treatment of patients with infections in hematopoietic stem cell transplantation. Price, T.H., Bowden, R.A., Boeckh, M., Bux, J., Nelson, K., Liles, W.C., Dale, D.C. Blood (2000) [Pubmed]
  10. Proteolysis of von Willebrand factor in therapeutic plasma concentrates. Mannuccio, P.M., Lattuada, A., Ruggeri, Z.M. Blood (1994) [Pubmed]
  11. Prevention of transfusion-induced Chagas' disease by amphotericin B. Cruz, F.S., Marr, J.J., Berens, R.L. Am. J. Trop. Med. Hyg. (1980) [Pubmed]
  12. A strategy for the prevention of the transmission of Chagas' disease during blood transfusion. Hammond, D.J., Croft, S.L., Hogg, J., Gutteridge, W.E. Acta Trop. (1986) [Pubmed]
  13. Glycoprotein Ib bioassays. Activity levels in Bernard-Soulier syndrome and in stored blood bank platelets. Eaton, L.A., Read, M.S., Brinkhous, K.M. Arch. Pathol. Lab. Med. (1991) [Pubmed]
  14. Beneficial effects of antioxidants in hemorrhagic shock. Kapoor, R., Prasad, K. Angiology. (1995) [Pubmed]
  15. Sterility and quality of blood dispensed in syringes for infants. Strauss, R.G., Crawford, G.F., Elbert, C., Floss, A.M., Liesch, M. Transfusion (1986) [Pubmed]
  16. Reversal of the storage lesion of CPD bank blood: a problem in clinical medicine. Gibson, J.G., McCue, J.P. Transfusion (1978) [Pubmed]
  17. Autotransfusion of shed mediastinal blood after cardiac surgery: a prospective study. Schaff, H.V., Hauer, J.M., Bell, W.R., Gardner, T.J., Donahoo, J.S., Gott, V.L., Brawley, R.K. J. Thorac. Cardiovasc. Surg. (1978) [Pubmed]
  18. Immunoreactive endorphin peptides and prolactin in umbilical vein and maternal blood. Kimball, C.D., Chang, C.M., Huang, S.M., Houck, J.C. Am. J. Obstet. Gynecol. (1981) [Pubmed]
  19. Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor. Weibrich, G., Kleis, W.K., Kunz-Kostomanolakis, M., Loos, A.H., Wagner, W. The International journal of oral & maxillofacial implants. (2001) [Pubmed]
  20. Immunoradiometric quantitation of tissue plasminogen activator-related antigen in human plasma: crypticity phenomenon and relationship to plasma fibrinolysis. Wun, T.C., Capuano, A. Blood (1987) [Pubmed]
  21. Platelet membrane glycoprotein changes during the preparation and storage of platelet concentrates. George, J.N., Pickett, E.B., Heinz, R. Transfusion (1988) [Pubmed]
  22. Studies of factors regulating the ageing of human erythrocytes. II. Metabolic depletion of erythrocytes is not accompanied by a decrease of their sialic acid content during blood bank storage. Pessina, G.P., Paulesu, L., Bocci, V. Vox Sang. (1979) [Pubmed]
  23. Accumulation of hexachlorobenzene in humans: a long standing risk. To-Figueras, J., Barrot, C., Rodamilans, M., Gómez-Catalán, J., Torra, M., Brunet, M., Sabater, F., Corbella, J. Human & experimental toxicology. (1995) [Pubmed]
  24. Ultrastructural study of type C virus particles in phytohemagglutinin-stimulated lymphocytes from healthy adults seropositive to adult T-cell leukemia-associated antigens. Ohtsuki, Y., Miyoshi, I., Taguchi, H., Takahashi, K., Akagi, T. Acta Pathol. Jpn. (1984) [Pubmed]
  25. Spectrin oxidation correlates with membrane vesiculation in stored RBCs. Wagner, G.M., Chiu, D.T., Qju, J.H., Heath, R.H., Lubin, B.H. Blood (1987) [Pubmed]
  26. Liquid chromatography of serotonin and adenine nucleotides in blood platelets, illustrated by evaluation of functional integrity of platelet preparations. Ingebretsen, O.C., Bakken, A.M., Farstad, M. Clin. Chem. (1985) [Pubmed]
  27. Thimerosal-dependent agglutination complicating the serologic evaluation for unexpected antibodies. Shulman, I.A., Simpson, R.B., Farmer, C.F., Lam, H.T. Transfusion (1984) [Pubmed]
  28. Metabolic changes during platelet storage. Rock, G., Figueredo, A. Transfusion (1976) [Pubmed]
  29. Hemoglobin function in stored blood. XIX. Inosine maintenance of 2,3-DPG for 35 days in a CPD-adenine preservative. Dawson, R.B. Transfusion (1977) [Pubmed]
  30. Quantitation of CD62, soluble CD62, and lysosome-associated membrane proteins 1 and 2 for evaluation of the quality of stored platelet concentrates. Divers, S.G., Kannan, K., Stewart, R.M., Betzing, K.W., Dempsey, D., Fukuda, M., Chervenak, R., Holcombe, R.F. Transfusion (1995) [Pubmed]
  31. Screening for autoantibodies to tissue transglutaminase reveals a low prevalence of celiac disease in blood donors with cryptogenic hypertransaminasemia. Soresi, M., Amplo, M., Agliastro, R., Sesti, R., Di Giovanni, G., Magliarisi, C., Belvedere, M., Carroccio, A., Montalto, G. Digestion (2001) [Pubmed]
  32. Antibody to serum amyloid A. Rosenau, B.J., Schur, P.H. J. Autoimmun. (2004) [Pubmed]
  33. Clinical and blood bank factors in the management of platelet refractoriness and alloimmunization. Friedberg, R.C., Donnelly, S.F., Boyd, J.C., Gray, L.S., Mintz, P.D. Blood (1993) [Pubmed]
  34. Calcium-dependent proteolysis of actin during storage of platelet concentrates. Snyder, E.L., Horne, W.C., Napychank, P., Heinemann, F.S., Dunn, B. Blood (1989) [Pubmed]
  35. Reducing white cells in platelet units. Marx, G., Blankenfeld, A., Gorodetsky, R., BarShany, S. Transfusion (1991) [Pubmed]
  36. The role of the blood bank in hematopoietic stem cell transplantation. Anderson, K.C. Transfusion (1992) [Pubmed]
  37. A rational attitude toward serum alanine aminotransferase measurement by blood banks, based on a longitudinal study of a cohort of repeat blood donors. Driss, F., Costagliola, D., Marie, B., Ekindjian, O.G., Eme, D., Berthelot, P., Nalpas, B. Transfusion (1991) [Pubmed]
  38. Rapid detection of cardioactive bufalin toxicity using fluorescence polarization immunoassay for digitoxin. Dasgupta, A., Datta, P. Therapeutic drug monitoring. (1998) [Pubmed]
  39. Insoluble human plasma protein immunoadsorbents. Large-scale production and storage. Nerenberg, S.T., Prasad, R., Biskup, N., Pedersen, L. Clin. Chim. Acta (1977) [Pubmed]
WikiGenes - Universities