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MeSH Review

Fasciola hepatica

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Disease relevance of Fasciola hepatica


High impact information on Fasciola hepatica


Chemical compound and disease context of Fasciola hepatica


Biological context of Fasciola hepatica


Anatomical context of Fasciola hepatica


Associations of Fasciola hepatica with chemical compounds

  • Syrian golden hamsters experimentally infected with O. viverrini liver fluke excreted in the urine significantly greater amounts of nitrate, a stable oxidization product of NO, than untreated hamsters (3.64 +/- 0.86 versus 2.64 +/- 0.60 mumol/hamster/day, P < 0.001) [18].
  • Electron paramagnetic resonance properties of liver fluke (Dicrocoelium dendriticum) nitrosyl hemoglobin [19].
  • The proposed method was used to monitor raw milk samples for the market, and applied to the analysis of milk samples from 10 cows which had been administered with triclabendazole to control the liver fluke [20].
  • Data are then presented which demonstrate an elevation in levels of salivary nitrite and urinary and plasma nitrate among men with moderate and heavy liver fluke infections compared to uninfected controls which was absent 4 months after the parasites were cleared with praziquantel [21].
  • The liver fluke DPP is a serine proteinase of molecular weight > 200 kDa and differs from previously characterized mammalian DPPs in its substrate preference and susceptibility to inactivation by inhibitors [22].

Gene context of Fasciola hepatica

  • The protection observed in cattle vaccinated with native FABP of F. gigantica supports the notion that this class of proteins is a useful target for protection of animals against Fasciola and extends the efficacy of FABPs to the tropical liver fluke [23].
  • On the other hand, point-mutational activation of the c-Ki-ras proto-oncogene may be involved in cholangiocarcinogenesis in liver without preexisting liver-fluke or viral infection [24].
  • Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver [25].
  • Using human Echinococcus granulosus infection sera, Gal(beta1-6)Gal-terminating glycolipids could be allocated to the gut in adult liver fluke cryosections [26].
  • Using ELISAs, we compared the ability of liver fluke homogenates (LFH), excretory/secretory (ES) products, and CL1 to discriminate between seropositive (infected) and seronegative (noninfected) individuals within a population of 95 patients from the Bolivian Altiplano [27].

Analytical, diagnostic and therapeutic context of Fasciola hepatica


  1. The epidemiology of cholangiocarcinoma. Shaib, Y., El-Serag, H.B. Semin. Liver Dis. (2004) [Pubmed]
  2. Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma. Limpaiboon, T., Khaenam, P., Chinnasri, P., Soonklang, M., Jearanaikoon, P., Sripa, B., Pairojkul, C., Bhudhisawasdi, V. Cancer Lett. (2005) [Pubmed]
  3. Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., Ito, N. Teratog., Carcinog. Mutagen. (1994) [Pubmed]
  4. Rhodoquinone and complex II of the electron transport chain in anaerobically functioning eukaryotes. Van Hellemond, J.J., Klockiewicz, M., Gaasenbeek, C.P., Roos, M.H., Tielens, A.G. J. Biol. Chem. (1995) [Pubmed]
  5. Kinetics of oxygen and carbon monoxide binding to liver fluke (Dicrocoelium dendriticum) hemoglobin. An extreme case? Di Iorio, E.E., Meier, U.T., Smit, J.D., Winterhalter, K.H. J. Biol. Chem. (1985) [Pubmed]
  6. Nuclear magnetic resonance studies of carbohydrate metabolism and substrate cycling in Fasciola hepatica. Matthews, P.M., Foxall, D., Shen, L., Mansour, T.E. Mol. Pharmacol. (1986) [Pubmed]
  7. Infrequent microsatellite instability in liver fluke infection-associated intrahepatic cholangiocarcinomas from Thailand. Liengswangwong, U., Nitta, T., Kashiwagi, H., Kikukawa, H., Kawamoto, T., Todoroki, T., Uchida, K., Khuhaprema, T., Karalak, A., Srivatanakul, P., Miwa, M. Int. J. Cancer (2003) [Pubmed]
  8. Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection. Law, R.H., Smooker, P.M., Irving, J.A., Piedrafita, D., Ponting, R., Kennedy, N.J., Whisstock, J.C., Pike, R.N., Spithill, T.W. Infect. Immun. (2003) [Pubmed]
  9. Level of Opisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters. Thamavit, W., Kongkanuntn, R., Tiwawech, D., Moore, M.A. Virchows Arch., B, Cell Pathol. (1987) [Pubmed]
  10. Polyamine N-acetyltransferase from Fasciola hepatica. Aisien, S.O., Walter, R.D. Mol. Biochem. Parasitol. (1992) [Pubmed]
  11. Opisthorchiasis control in Thailand. Jongsuksuntigul, P., Imsomboon, T. Acta Trop. (2003) [Pubmed]
  12. Microsatellite alterations in liver fluke related cholangiocarcinoma are associated with poor prognosis. Limpaiboon, T., Krissadarak, K., Sripa, B., Jearanaikoon, P., Bhuhisawasdi, V., Chau-in, S., Romphruk, A., Pairojkul, C. Cancer Lett. (2002) [Pubmed]
  13. The formation of propionate and acetate as terminal processes in the energy metabolism of the adult liver fluke Fasciola hepatica. van Vugt, F., van der Meer, P., van den Bergh, S.G. Int. J. Biochem. (1979) [Pubmed]
  14. Promotion of N-nitrosodimethylamine-initiated bile duct carcinogenesis in the hamster by the human liver fluke, Opisthorchis viverrini. Flavell, D.J., Lucas, S.B. Carcinogenesis (1983) [Pubmed]
  15. The use of antibody-secreting cell probes to reveal tissue-restricted immune responses during infection. Meeusen, E., Brandon, M. Eur. J. Immunol. (1994) [Pubmed]
  16. Potentiation by the human liver fluke, Opisthorchis viverrini, of the carcinogenic action of N-nitrosodimethylamine upon the biliary epithelium of the hamster. Flavell, D.J., Lucas, S.B. Br. J. Cancer (1982) [Pubmed]
  17. Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica. Smith, A.M., Dowd, A.J., McGonigle, S., Keegan, P.S., Brennan, G., Trudgett, A., Dalton, J.P. Mol. Biochem. Parasitol. (1993) [Pubmed]
  18. Increased nitrosamine and nitrate biosynthesis mediated by nitric oxide synthase induced in hamsters infected with liver fluke (Opisthorchis viverrini). Ohshima, H., Bandaletova, T.Y., Brouet, I., Bartsch, H., Kirby, G., Ogunbiyi, F., Vatanasapt, V., Pipitgool, V. Carcinogenesis (1994) [Pubmed]
  19. Electron paramagnetic resonance properties of liver fluke (Dicrocoelium dendriticum) nitrosyl hemoglobin. Desideri, A., Meier, U.T., Winterhalter, K.H., Di Iorio, E.E. FEBS Lett. (1984) [Pubmed]
  20. Simultaneous determination of triclabendazole and its sulphoxide and sulphone metabolites in bovine milk by high-performance liquid chromatography. Takeba, K., Fujinuma, K., Sakamoto, M., Miyazaki, T., Oka, H., Itoh, Y., Nakazawa, H. Journal of chromatography. A. (2000) [Pubmed]
  21. Liver fluke infection and cholangiocarcinoma: model of endogenous nitric oxide and extragastric nitrosation in human carcinogenesis. Haswell-Elkins, M.R., Satarug, S., Tsuda, M., Mairiang, E., Esumi, H., Sithithaworn, P., Mairiang, P., Saitoh, M., Yongvanit, P., Elkins, D.B. Mutat. Res. (1994) [Pubmed]
  22. A dipeptidylpeptidase secreted by Fasciola hepatica. Carmona, C., McGonigle, S., Dowd, A.J., Smith, A.M., Coughlan, S., McGowran, E., Dalton, J.P. Parasitology (1994) [Pubmed]
  23. Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle. Estuningsih, S.E., Smooker, P.M., Wiedosari, E., Widjajanti, S., Vaiano, S., Partoutomo, S., Spithill, T.W. Int. J. Parasitol. (1997) [Pubmed]
  24. Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene. Tsuda, H., Satarug, S., Bhudhisawasdi, V., Kihana, T., Sugimura, T., Hirohashi, S. Mol. Carcinog. (1992) [Pubmed]
  25. Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Kirby, G.M., Pelkonen, P., Vatanasapt, V., Camus, A.M., Wild, C.P., Lang, M.A. Mol. Carcinog. (1994) [Pubmed]
  26. The parasitic trematode Fasciola hepatica exhibits mammalian-type glycolipids as well as Gal(beta1-6)Gal-terminating glycolipids that account for cestode serological cross-reactivity. Wuhrer, M., Grimm, C., Dennis, R.D., Idris, M.A., Geyer, R. Glycobiology (2004) [Pubmed]
  27. Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase. O'Neill, S.M., Parkinson, M., Strauss, W., Angles, R., Dalton, J.P. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
  28. Restriction enzyme mapping of ribosomal DNA can distinguish between fasciolid (liver fluke) species. Blair, D., McManus, D.P. Mol. Biochem. Parasitol. (1989) [Pubmed]
  29. Partial purification and characterization of cAMP-dependent protein kinase from Fasciola hepatica. Iltzsch, M.H., Mansour, T.E. Mol. Biochem. Parasitol. (1987) [Pubmed]
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