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Chemical Compound Review

Neoxazoi     4-amino-N-(3,4-dimethyl-1,2- oxazol-5...

Synonyms: Accuzole, Sulfazin, Gantrisin, Sulfafurazole, Sulfasoxizole, ...
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Disease relevance of Tl-azole


Psychiatry related information on Tl-azole

  • The two regimens prescribed were equally effective in eradicating the infection, but after the discontinuation of the 10-day treatment with sulfafurazole, 17 (23%) of 73 patients with their upper urinary tract infection experienced a recurrence within one month, as compared to only one (1) of 76 subjects in the 42-day therapy group [5].

High impact information on Tl-azole


Chemical compound and disease context of Tl-azole


Biological context of Tl-azole


Anatomical context of Tl-azole


Associations of Tl-azole with other chemical compounds

  • All 56 isolates collected between 1984 and 1987 were susceptible to all antibiotics tested; 13 (7.4%) of 176 strains isolated between 1989 and 1991 were resistant to streptomycin, sulfisoxazole, and tetracycline. lambda-restriction fragment length polymorphism analysis suggested that the 13 resistant strains belonged to nine different clones [26].
  • Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora [27].
  • The in vivo effect of bilirubin and sulfisoxazole on cerebral oxygen, glucose, and lactate metabolism in newborn piglets [28].
  • The increases were then applied to baseline UBC, determined by linear regression analysis of binding data (peroxidase method) from 86 newborns, at total bilirubins of 12 mg/dL for sulfisoxazole and 10 mg/dL for benzoate [14].
  • This suggests that a single dose of amikacin is as effective as a 10-day course of sulfisoxazole in the treatment of presumed first lower urinary tract infection in girls [15].

Gene context of Tl-azole


Analytical, diagnostic and therapeutic context of Tl-azole

  • The remaining kidney function was preserved, and the patient had a very favorable outcome because of early diagnosis and prompt treatment with sulfisoxazole [31].
  • All isolates for which the sulfisoxazole MIC was >/=8 possessed the C682A mutation by real-time PCR or folP sequencing, and 34 of 35 isolates with a MIC of </=2 lacked this mutation [32].
  • Sulfisoxazole chemoprophylaxis for frequent otitis media [33].
  • Sulfisoxazole, 75 mg/kg/d in two divided doses for 3 months, was administered in a double-blind placebo crossover study to 35 children aged 6 months to 5 years who had frequent recurring episodes of otitis media [33].
  • A similar increase was not observed in swine after oral or intravenous administration of sulfisoxazole (100 mg/kg) or in humans (approximately 28 mg/kg) after oral administration or in dogs (100 mg/kg) after intravenous administration [34].


  1. Streptomycin and sulfisoxazole for treatment of Haemophilus influenzae meningitis. Meade, R.H. JAMA (1978) [Pubmed]
  2. Sulfisoxazole-induced thrombocytopenic purpura. Immunologic mechanism as cause. Hamilton, H.E., Sheets, R.F. JAMA (1978) [Pubmed]
  3. Acquired circulating anticoagulant to factor VIII. Response to high doses of cryoprecipitate and immunosuppressive therapy. Vera, J.C., Herzig, E.G., Sise, H.S., Brauer, M.J. JAMA (1975) [Pubmed]
  4. Minocycline treatment of pulmonary nocardiosis. Petersen, E.A., Nash, M.L., Mammana, R.B., Copeland, J.G. JAMA (1983) [Pubmed]
  5. The length of antimicrobial therapy in upper vs. lower urinary tract infection of childhood. Pylkkänen, J., Vilska, J., Koskimies, O. Acta paediatrica Scandinavica. (1981) [Pubmed]
  6. Treatment of chancroid. Comparison of sulfamethoxazole-trimethoprim with recommended therapies. Fitzpatrick, J.E., Tyler, H., Gramstad, N.D. JAMA (1981) [Pubmed]
  7. Differential response of chlamydial and ureaplasma-associated urethritis to sulphafurazole (sulfisoxazole) and aminocyclitols. Bowie, W.R., Floyd, J.F., Miller, Y., Alexander, E.R., Holmes, J., Holmes, K.K. Lancet (1976) [Pubmed]
  8. Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. Johnston, R.B., Wilfert, C.M., Buckley, R.H., Webb, L.S., DcChatelet, L.R., McCall, C.E. Lancet (1975) [Pubmed]
  9. Urinary protein binding does not affect response to furosemide in patients with nephrotic syndrome. Agarwal, R., Gorski, J.C., Sundblad, K., Brater, D.C. J. Am. Soc. Nephrol. (2000) [Pubmed]
  10. Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis. Wang, L.L., Henson, E., McClarty, G. Mol. Microbiol. (1994) [Pubmed]
  11. Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Curtis, B.R., McFarland, J.G., Wu, G.G., Visentin, G.P., Aster, R.H. Blood (1994) [Pubmed]
  12. Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages. Perronne, C., Gikas, A., Truffot-Pernot, C., Grosset, J., Pocidalo, J.J., Vilde, J.L. Antimicrob. Agents Chemother. (1990) [Pubmed]
  13. Prevalence of Escherichia coli O157 in Saskatchewan cattle: characterization of isolates by using random amplified polymorphic DNA PCR, antibiotic resistance profiles, and pathogenicity determinants. Vidovic, S., Korber, D.R. Appl. Environ. Microbiol. (2006) [Pubmed]
  14. Unbound bilirubin associated with kernicterus: a historical approach. Ahlfors, C.E. J. Pediatr. (2000) [Pubmed]
  15. Single-dose amikacin treatment of first childhood E. coli lower urinary tract infections. Wallen, L., Zeller, W.P., Goessler, M., Connor, E., Yogev, R. J. Pediatr. (1983) [Pubmed]
  16. Abnormal serum protein binding of acidic drugs in diabetes mellitus. Ruiz-Cabello, F., Erill, S. Clin. Pharmacol. Ther. (1984) [Pubmed]
  17. Pharmacokinetics of sulfisoxazole in renal transplant patients. Shermantine, M., Gambertoglio, J., Amend, W., Vincenti, F., Oie, S. Antimicrob. Agents Chemother. (1985) [Pubmed]
  18. Kinetics of sulphafurazole in undernutrition. Shastri, R.A. British journal of clinical pharmacology. (1980) [Pubmed]
  19. Bioavailability of 11 sulfisoxazole products in humans. Slywka, G.W., Melikian, A.P., Straughn, A.B., Whyatt, P.L., Meyer, M.C. Journal of pharmaceutical sciences. (1976) [Pubmed]
  20. Effect of dioctyl sodium sulfosuccinate and poloxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats. Reddy, R.K., Khalil, S.A., Gouda, M.W. Journal of pharmaceutical sciences. (1976) [Pubmed]
  21. Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. Kalish, R.S., LaPorte, A., Wood, J.A., Johnson, K.L. J. Allergy Clin. Immunol. (1994) [Pubmed]
  22. "High-pressure" liquid chromatography of sulfisoxazole and N4-acetylsulfisoxazole in body fluids. Jung, D., Oie, S. Clin. Chem. (1980) [Pubmed]
  23. The susceptibility of Haemophilus influenzae middle ear and sinus isolates to sulphisoxazole. Sheeran, P.W., Smith, A.L., Mendelman, P.L. J. Antimicrob. Chemother. (1994) [Pubmed]
  24. Sulfisoxazole in human milk. Elliott, G.T., Quinn, S.L. J. Pediatr. (1981) [Pubmed]
  25. Regional variation in electrically-evoked contractions of rabbit isolated pulmonary artery. Jackson, V.M., Trout, S.J., Cunnane, T.C. Br. J. Pharmacol. (2002) [Pubmed]
  26. Characteristics of antibiotic-resistant Escherichia coli O157:H7 in Washington State, 1984-1991. Kim, H.H., Samadpour, M., Grimm, L., Clausen, C.R., Besser, T.E., Baylor, M., Kobayashi, J.M., Neill, M.A., Schoenknecht, F.D., Tarr, P.I. J. Infect. Dis. (1994) [Pubmed]
  27. Treatment of uncomplicated urinary tract infections with trimethoprim versus sulfisoxazole, with special reference to antibody-coated bacteria and fecal flora. Iravani, A., Richard, G.A., Baer, H. Antimicrob. Agents Chemother. (1981) [Pubmed]
  28. The in vivo effect of bilirubin and sulfisoxazole on cerebral oxygen, glucose, and lactate metabolism in newborn piglets. Brann, B.S., Stonestreet, B.S., Oh, W., Cashore, W.J. Pediatr. Res. (1987) [Pubmed]
  29. Sulfisoxazole, an endothelin receptor antagonist, protects retinal neurones from insults of ischemia/reperfusion or lipopolysaccharide. Syed, H., Safa, R., Chidlow, G., Osborne, N.N. Neurochem. Int. (2006) [Pubmed]
  30. In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonists. Raszka, W.V., Skillman, L.P., McEvoy, P.L. Diagn. Microbiol. Infect. Dis. (1994) [Pubmed]
  31. Persistent nocardemia following renal transplantation. Association with pulmonary nocardiosis. Avram, M.M., Nair, S.R., Lipner, H.I., Cherubin, C.E. JAMA (1978) [Pubmed]
  32. Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents. Fiebelkorn, K.R., Crawford, S.A., Jorgensen, J.H. Antimicrob. Agents Chemother. (2005) [Pubmed]
  33. Sulfisoxazole chemoprophylaxis for frequent otitis media. Liston, T.E., Foshee, W.S., Pierson, W.D. Pediatrics (1983) [Pubmed]
  34. Comparison of serum bilirubin levels in humans and two monogastric animal species after a single administration of sulfisoxazole. Suber, R.L., Gudat, J.C., Edds, G.T. Journal of pharmaceutical sciences. (1982) [Pubmed]
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