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Gene Review

SOD1  -  superoxide dismutase 1, soluble

Sus scrofa

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Disease relevance of SOD1


High impact information on SOD1


Chemical compound and disease context of SOD1


Biological context of SOD1


Anatomical context of SOD1


Associations of SOD1 with chemical compounds


Physical interactions of SOD1


Regulatory relationships of SOD1


Other interactions of SOD1


Analytical, diagnostic and therapeutic context of SOD1


  1. Limitation of myocardial infarct size by superoxide dismutase as an adjunct to reperfusion after different durations of coronary occlusion in the pig. Näslund, U., Häggmark, S., Johansson, G., Marklund, S.L., Reiz, S. Circ. Res. (1990) [Pubmed]
  2. Autosomal dominant amyotrophic lateral sclerosis: a novel mutation in the Cu/Zn superoxide dismutase-1 gene. Kostrzewa, M., Burck-Lehmann, U., Müller, U. Hum. Mol. Genet. (1994) [Pubmed]
  3. Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. Freeman, B.A., Young, S.L., Crapo, J.D. J. Biol. Chem. (1983) [Pubmed]
  4. Polyethylene glycol-conjugated superoxide dismutase fails to augment brain superoxide dismutase activity in piglets. Haun, S.E., Kirsch, J.R., Helfaer, M.A., Kubos, K.L., Traystman, R.J. Stroke (1991) [Pubmed]
  5. Toxic oxygen products alter calcium homeostasis in an asthma model. Weiss, E.B. J. Allergy Clin. Immunol. (1985) [Pubmed]
  6. Differential effects of hydrogen peroxide on indices of endothelial cell function. Ager, A., Gordon, J.L. J. Exp. Med. (1984) [Pubmed]
  7. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. Boulanger, C., Lüscher, T.F. J. Clin. Invest. (1990) [Pubmed]
  8. Induction of heat-shock gene expression in postischemic pig liver depends on superoxide generation. Schoeniger, L.O., Andreoni, K.A., Ott, G.R., Risby, T.H., Bulkley, G.B., Udelsman, R., Burdick, J.F., Buchman, T.G. Gastroenterology (1994) [Pubmed]
  9. Coronary endothelial injury after cardiopulmonary bypass and ischemic cardioplegia is mediated by oxygen-derived free radicals. Sellke, F.W., Shafique, T., Ely, D.L., Weintraub, R.M. Circulation (1993) [Pubmed]
  10. Control of coronary vascular tone by nitric oxide. Kelm, M., Schrader, J. Circ. Res. (1990) [Pubmed]
  11. Reduced blood-brain barrier permeability after cardiac arrest by conjugated superoxide dismutase and catalase in piglets. Schleien, C.L., Eberle, B., Shaffner, D.H., Koehler, R.C., Traystman, R.J. Stroke (1994) [Pubmed]
  12. Role of oxygen-derived free radicals in protease activation after pancreas transplantation in the pig. Petersson, U., Källén, R., Montgomery, A., Borgström, A. Transplantation (1998) [Pubmed]
  13. Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model. Malo, O., Desjardins, F., Tanguay, J.F., Tardif, J.C., Carrier, M., Perrault, L.P. Cardiovasc. Res. (2003) [Pubmed]
  14. Alterations in the superoxide dismutase gene of an isoniazid-resistant strain of Mycobacterium tuberculosis. Zhang, Y., Garcia, M.J., Lathigra, R., Allen, B., Moreno, C., van Embden, J.D., Young, D. Infect. Immun. (1992) [Pubmed]
  15. Assignment of superoxide dismutase (SOD-1) gene to chromosome No. 9 of domestic pig. Leong, M.M., Lin, C.C., Ruth, R.F. Can. J. Genet. Cytol. (1983) [Pubmed]
  16. Developmental expression of antioxidant enzymes in guinea pig lung and liver. Rickett, G.M., Kelly, F.J. Development (1990) [Pubmed]
  17. The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells. Sharpe, P.C., Yue, K.K., Catherwood, M.A., McMaster, D., Trimble, E.R. Diabetologia (1998) [Pubmed]
  18. Glutathione dependent reduction of alloxan to dialuric acid catalyzed by thioltransferase (glutaredoxin): a possible role for thioltransferase in alloxan toxicity. Washburn, M.P., Wells, W.W. Free Radic. Biol. Med. (1997) [Pubmed]
  19. Beneficial effects of coronary venous retroinfusion but not left atrial administration of superoxide dismutase on myocardial necrosis in pigs. Hatori, N., Tadokoro, H., Satomura, K., Miyazaki, A., Fishbein, M.C., Rydén, L., Corday, E., Drury, J.K. Eur. Heart J. (1991) [Pubmed]
  20. Oxidized low-density lipoprotein correlates positively with toll-like receptor 2 and interferon regulatory factor-1 and inversely with superoxide dismutase-1 expression: studies in hypercholesterolemic swine and THP-1 cells. Holvoet, P., Davey, P.C., De Keyzer, D., Doukouré, M., Deridder, E., Bochaton-Piallat, M.L., Gabbiani, G., Beaufort, E., Bishay, K., Andrieux, N., Benhabilès, N., Marguerie, G. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  21. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. Nishinaga, M., Ozawa, T., Shimada, K. J. Clin. Invest. (1993) [Pubmed]
  22. The alteration of superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H cytochrome c reductase in guinea pig polymorphonuclear leukocytes and alveolar macrophages during hyperoxia. Rister, M., Baehner, R.L. J. Clin. Invest. (1976) [Pubmed]
  23. Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias. Pallandi, R.T., Perry, M.A., Campbell, T.J. Circ. Res. (1987) [Pubmed]
  24. Inhibition by superoxide dismutase of methemoglobin formation from oxyhemoglobin. Lynch, R.E., Lee, R., Cartwright, G.E. J. Biol. Chem. (1976) [Pubmed]
  25. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. Sun, J.Z., Tang, X.L., Park, S.W., Qiu, Y., Turrens, J.F., Bolli, R. J. Clin. Invest. (1996) [Pubmed]
  26. Reoxygenation-induced relaxation of coronary arteries. A novel endothelium-dependent mechanism. Close, L.A., Bowman, P.S., Paul, R.J. Circ. Res. (1994) [Pubmed]
  27. Mechanism of CO2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways. Wagerle, L.C., Mishra, O.P. Circ. Res. (1988) [Pubmed]
  28. The respiratory burst oxidase of neutrophils. Separation of an FAD enzyme and its characterization. Kakinuma, K., Fukuhara, Y., Kaneda, M. J. Biol. Chem. (1987) [Pubmed]
  29. Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities? Nikolic, M., Vranic, D., Spiric, A., Batas, V., Nikolic-Kokic, A., Radetic, P., Turubatovic, L., Blagojevic, D.P., Jones, D.R., Niketic, V., Spasic, M.B. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  30. Endothelium-derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells. Martin, W., White, D.G., Henderson, A.H. Br. J. Pharmacol. (1988) [Pubmed]
  31. Effects of superoxide dismutase on cholesterol 7 alpha-hydroxylation in swine. Li, J.R., Kim, D.N. Steroids (1980) [Pubmed]
  32. Uteroferrin induces lipid peroxidation in endometrial and conceptus microsomal membranes and is inhibited by apotransferrin, retinol binding protein, and the uteroferrin-associated proteins. Vallet, J.L. Biol. Reprod. (1995) [Pubmed]
  33. Cryopreservation of pig granulosa cells: effect of FSH addition to freezing medium. Tirelli, M., Basini, G., Grasselli, F., Bianco, F., Tamanini, C. Domest. Anim. Endocrinol. (2005) [Pubmed]
  34. Inhibition of inducible nitric oxide synthase restores endothelium-dependent relaxations in proinflammatory mediator-induced blood vessels. Kessler, P., Bauersachs, J., Busse, R., Schini-Kerth, V.B. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  35. Developmental changes in hepatic copper proteins in the guinea pig. Bingle, C.D., Srai, S.K., Epstein, O. J. Hepatol. (1990) [Pubmed]
  36. Superoxide does not mediate the acute vasoconstrictor effects of angiotensin II: a study in human and porcine arteries. Schuijt, M.P., Tom, B., de Vries, R., Saxena, P.R., Sluiter, W., van Kats, J.P., Danser, A.H. J. Hypertens. (2003) [Pubmed]
  37. Nitric oxide in the development of obliterative bronchiolitis in a heterotopic pig model. Salminen, U.S., Maasilta, P.K., Harjula, A.L., Romanska, H.M., Bishop, A.E., Polak, J.M. Transplantation (2002) [Pubmed]
  38. Effect of graft preservation and IgM depletion on guinea pig to rat cardiac xenograft survival. Hori, S., Havaux, X., Rubay, R., Latinne, D., Bazin, H., Gianello, P. Transplantation (1997) [Pubmed]
  39. A superoxide dismutase C mutant of Haemophilus ducreyi is virulent in human volunteers. Bong, C.T., Fortney, K.R., Katz, B.P., Hood, A.F., San Mateo, L.R., Kawula, T.H., Spinola, S.M. Infect. Immun. (2002) [Pubmed]
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