Gene Review:
OXT - oxytocin/neurophysin I prepropeptide
Homo sapiens
Synonyms:
OT, OT-NPI, OXT-NPI, Oxytocin-neurophysin 1
Gimpl,
Fahrenholz,
Richter,
Kübler,
Schmolling,
Kupka,
Reinsberg,
Ulrich,
van der Ven,
Wardelmann,
van der Ven,
Péqueux,
Breton,
Hendrick,
Hagelstein,
Martens,
Winkler,
Geenen,
Legros,
- The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Rao, V.V., Löffler, C., Battey, J., Hansmann, I. Cytogenet. Cell Genet. (1992)
- Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway. Copland, J.A., Jeng, Y.J., Strakova, Z., Ives, K.L., Hellmich, M.R., Soloff, M.S. Endocrinology (1999)
- Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation. Zhong, M., Yang, M., Sanborn, B.M. Endocrinology (2003)
- Role of oxytocin in the ejaculatory process. Filippi, S., Vignozzi, L., Vannelli, G.B., Ledda, F., Forti, G., Maggi, M. J. Endocrinol. Invest. (2003)
- Decreased number of oxytocin neurons in the paraventricular nucleus of the human hypothalamus in AIDS. Purba, J.S., Hofman, M.A., Portegies, P., Troost, D., Swaab, D.F. Brain (1993)
- Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Purba, J.S., Hoogendijk, W.J., Hofman, M.A., Swaab, D.F. Arch. Gen. Psychiatry (1996)
- Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. Swaab, D.F., Purba, J.S., Hofman, M.A. J. Clin. Endocrinol. Metab. (1995)
- Role of oxytocin in the neuroadaptation to drugs of abuse. Sarnyai, Z., Kovács, G.L. Psychoneuroendocrinology (1994)
- The oxytocin receptor system: structure, function, and regulation. Gimpl, G., Fahrenholz, F. Physiol. Rev. (2001)
- Neurohypophysial hormone secretion in hyperprolactinaemic women. Laczi, F., Szasz, A., Vecsernyes, M., Julesz, J. Neuropeptides (1998)
- Activation of functional oxytocin receptors stimulates cell proliferation in human trophoblast and choriocarcinoma cell lines. Cassoni, P., Sapino, A., Munaron, L., Deaglio, S., Chini, B., Graziani, A., Ahmed, A., Bussolati, G. Endocrinology (2001)
- Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility. Vignozzi, L., Filippi, S., Luconi, M., Morelli, A., Mancina, R., Marini, M., Vannelli, G.B., Granchi, S., Orlando, C., Gelmini, S., Ledda, F., Forti, G., Maggi, M. Endocrinology (2004)
- Cerebrospinal fluid neurohypophysial peptides in benign intracranial hypertension. Seckl, J., Lightman, S. J. Neurol. Neurosurg. Psychiatr. (1988)
- Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling. Péqueux, C., Breton, C., Hendrick, J.C., Hagelstein, M.T., Martens, H., Winkler, R., Geenen, V., Legros, J.J. Cancer Res. (2002)
- The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. Sausville, E., Carney, D., Battey, J. J. Biol. Chem. (1985)
- Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis. Filippi, S., Morelli, A., Vignozzi, L., Vannelli, G.B., Marini, M., Ferruzzi, P., Mancina, R., Crescioli, C., Mondaini, N., Forti, G., Ledda, F., Maggi, M. Endocrinology (2005)
- Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. Blanks, A.M., Vatish, M., Allen, M.J., Ladds, G., de Wit, N.C., Slater, D.M., Thornton, S. J. Clin. Endocrinol. Metab. (2003)
- Hypothalamic oxytocin: a cerebrovascular modulator in man? Abrams, G.M., Nilaver, G., Recht, L.R., Haldar, J., Zimmerman, E.A. Neurology (1985)
- Residues in the hydrophilic face of putative helix 8 of oxytocin receptor are important for receptor function. Zhong, M., Navratil, A.M., Clay, C., Sanborn, B.M. Biochemistry (2004)
- Estrogen receptor-beta in oxytocin and vasopressin neurons of the rat and human hypothalamus: Immunocytochemical and in situ hybridization studies. Hrabovszky, E., Kalló, I., Steinhauser, A., Merchenthaler, I., Coen, C.W., Petersen, S.L., Liposits, Z. J. Comp. Neurol. (2004)
- Identification of neurohypophysial hormone receptor domains involved in ligand binding and G protein coupling. Postina, R., Kojro, E., Fahrenholz, F. Adv. Exp. Med. Biol. (1998)
- The DRY motif as a molecular switch of the human oxytocin receptor. Favre, N., Fanelli, F., Missotten, M., Nichols, A., Wilson, J., di Tiani, M., Rommel, C., Scheer, A. Biochemistry (2005)
- Different effects of the serotonergic agonists buspirone and sumatriptan on the posterior pituitary hormonal responses to hypoglycemia in humans. Chiodera, P., Volpi, R., Capretti, L., Caffarri, G., Magotti, M.G., Coiro, V. Neuropeptides (1996)
- Phorbol ester treatment of human myometrial cells suppresses expression of oxytocin receptor through a mechanism that does not involve activator protein-1. Ball, A., Wang, J.W., Wong, S., Zielnik, B., Mitchell, J., Wang, N., Stemerman, M.B., Mitchell, B.F. Am. J. Physiol. Endocrinol. Metab. (2006)
- Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells. Sano, M., Itakura, A., Ito, M., Takeuchi, M., Okada, M., Kotani, T., Mizutani, S., Kikkawa, F. Med. Sci. Monit. (2005)
- The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene. Stedronsky, K., Telgmann, R., Tillmann, G., Walther, N., Ivell, R. J. Neuroendocrinol. (2002)
- Oxytocin reduces metyrapone-induced ACTH secretion in human subjects. Chiodera, P., Coiro, V. Brain Res. (1987)
- Potential use of oxytocin and vasopressin V1a antagonists in the treatment of preterm labour and primary dysmenorrhoea. Akerlund, M., Melin, P., Maggi, M. Adv. Exp. Med. Biol. (1995)
- Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. Berrada, K., Plesnicher, C.L., Luo, X., Thibonnier, M. J. Biol. Chem. (2000)
- Effects of chronic alcoholic disease on magnocellular and parvocellular hypothalamic neurons in men. Sivukhina, E.V., Dolzhikov, A.A., Morozov, I.u.E., Jirikowski, G.F., Grinevich, V. Horm. Metab. Res. (2006)
- Expression of the vasopressin and oxytocin genes in human hypothalami. Mohr, E., Hillers, M., Ivell, R., Haulica, I.D., Richter, D. FEBS Lett. (1985)
- Oxytocin receptor gene expression of estrogen-stimulated human myometrium in extracorporeally perfused non-pregnant uteri. Richter, O.N., Kübler, K., Schmolling, J., Kupka, M., Reinsberg, J., Ulrich, U., van der Ven, H., Wardelmann, E., van der Ven, K. Mol. Hum. Reprod. (2004)
- Oxytocin and oxytocin-receptor mRNA expression in the human gastrointestinal tract: a polymerase chain reaction study. Monstein, H.J., Grahn, N., Truedsson, M., Ohlsson, B. Regul. Pept. (2004)