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Chemical Compound Review

AC1MHF75     2,7,11-triamino-3-[2-amino-3- (4...

Synonyms: L024104
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Disease relevance of Neuromedin N


Psychiatry related information on Neuromedin N


High impact information on Neuromedin N


Chemical compound and disease context of Neuromedin N


Biological context of Neuromedin N


Anatomical context of Neuromedin N


Associations of Neuromedin N with other chemical compounds


Gene context of Neuromedin N


Analytical, diagnostic and therapeutic context of Neuromedin N

  • By using a radioimmunoassay for neuromedin N (NMN), a hexapeptide in the neurotensin (NT) family, extracts of canine small intestine were found to contain primarily (greater than 75%) large molecular form(s) of NMN, whereas the predominant species in brain was NMN itself [27].
  • Neuromedin N-like immunoreactivity was present in 0.1 N HCl extracts of rat brain at a concentration of 9.3 +/- 1.3 pmol/g of tissue and behaved like synthetic neuromedin N on HPLC [28].
  • Unilateral microinjections of neuromedin N into the MPC at doses of 2.5, 5, 10, 20 and 40 nmol produced a dose-related decrease in ICSS of the ipsilateral MPC [29].
  • A novel neurotensin-like peptide, designated neuromedin N, has been isolated from porcine spinal cord by using a bioassay for a stimulant effect on guinea pig ileum [30].
  • We have established antibodies against peptide sequences of the NT/NMN precursor and developed a sandwich immunoassay for the detection of pro NT/NMN immunoreactivity in human circulation [31].


  1. Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells. Kislauskis, E., Dobner, P.R. Neuron (1990) [Pubmed]
  2. Presence of neurotensin and neuromedin-N within a common precursor from a human pancreatic neuroendocrine tumor. Carraway, R.E., Mitra, S.P., Feurle, G.E., Hacki, W.H. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  3. Site-specific DNA methylation contributes to neurotensin/neuromedin N expression in colon cancers. Dong, Z., Wang, X., Evers, B.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  4. Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors. Dubuc, I., Nouel, D., Coquerel, A., Menard, J.F., Kitabgi, P., Costentin, J. Eur. J. Pharmacol. (1988) [Pubmed]
  5. Phospholipase C activation by neurotensin and neuromedin N in Chinese hamster ovary cells expressing the rat neurotensin receptor. Hermans, E., Maloteaux, J.M., Octave, J.N. Brain Res. Mol. Brain Res. (1992) [Pubmed]
  6. A comparison of the effects of mesencephalic injections of neurotensin(1-13) and neuromedin N on brain electrical self-stimulation. Rompré, P.P., Gratton, A. Peptides (1992) [Pubmed]
  7. Distribution of neurotensin/neuromedin N mRNA in rat forebrain: unexpected abundance in hippocampus and subiculum. Alexander, M.J., Miller, M.A., Dorsa, D.M., Bullock, B.P., Melloni, R.H., Dobner, P.R., Leeman, S.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  8. Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Dobner, P.R., Barber, D.L., Villa-Komaroff, L., McKiernan, C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  9. Characterization of promoter elements required for cell-specific expression of the neurotensin/neuromedin N gene in a human endocrine cell line. Evers, B.M., Wang, X., Zhou, Z., Townsend, C.M., McNeil, G.P., Dobner, P.R. Mol. Cell. Biol. (1995) [Pubmed]
  10. Evidence that PC2 is the endogenous pro-neurotensin convertase in rMTC 6-23 cells and that PC1- and PC2-transfected PC12 cells differentially process pro-neurotensin. Rovère, C., Barbero, P., Kitabgi, P. J. Biol. Chem. (1996) [Pubmed]
  11. A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression. Tischler, A.S., Ruzicka, L.A., Dobner, P.R. J. Biol. Chem. (1991) [Pubmed]
  12. The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences. Kislauskis, E., Bullock, B., McNeil, S., Dobner, P.R. J. Biol. Chem. (1988) [Pubmed]
  13. Compared binding properties of 125I-labeled analogues of neurotensin and neuromedin N in rat and mouse brain. Gaudriault, G., Zsürger, N., Vincent, J.P. J. Neurochem. (1994) [Pubmed]
  14. C-fos mediates antipsychotic-induced neurotensin gene expression in the rodent striatum. Robertson, G.S., Tetzlaff, W., Bedard, A., St-Jean, M., Wigle, N. Neuroscience (1995) [Pubmed]
  15. Neuromedin-N is not released with neurotensin from rat ileum. Cuber, J.C., Herrmann, C., Kitabgi, P., Bosshard, A., Bernard, C., De Nadai, F., Chayvialle, J.A. Endocrinology (1990) [Pubmed]
  16. Neurotensin and neuromedin N are differently metabolized in ventral tegmental area and nucleus accumbens. Checler, F., Dauch, P., Masuo, Y., Vincent, J.P. J. Neurochem. (1991) [Pubmed]
  17. Potential precursors to neuromedin N in the cat and their processing by pepsin. Carraway, R.E., Mitra, S.P. Endocrinology (1987) [Pubmed]
  18. Lithium dramatically potentiates neurotensin/neuromedin N gene expression. Dobner, P.R., Tischler, A.S., Lee, Y.C., Bloom, S.R., Donahue, S.R. J. Biol. Chem. (1988) [Pubmed]
  19. c-fos antisense oligonucleotide specifically attenuates haloperidol-induced increases in neurotensin/neuromedin N mRNA expression in rat dorsal striatum. Merchant, K.M. Mol. Cell. Neurosci. (1994) [Pubmed]
  20. Stimulation of hepatocyte DNA synthesis by neurotensin. Hasegawa, K., Kar, S., Carr, B.I. J. Cell. Physiol. (1994) [Pubmed]
  21. Estrogen-regulated synthesis of neurotensin in neurosecretory cells of the hypothalamic arcuate nucleus in the female rat. Alexander, M.J. Endocrinology (1993) [Pubmed]
  22. Neurotensin receptors in human neoplasms: high incidence in Ewing's sarcomas. Reubi, J.C., Waser, B., Schaer, J.C., Laissue, J.A. Int. J. Cancer (1999) [Pubmed]
  23. Synergistic activation of neurotensin/neuromedin N gene expression by c-Jun and glucocorticoids: novel effects of Fos family proteins. Harrison, R.J., McNeil, G.P., Dobner, P.R. Mol. Endocrinol. (1995) [Pubmed]
  24. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. Bean, A.J., Dagerlind, A., Hökfelt, T., Dobner, P.R. Neuroscience (1992) [Pubmed]
  25. Species differences in brain pre-pro-neurotensin/neuromedin N mRNA distribution: the expression pattern in mice resembles more closely that of primates than rats. Smits, S.M., Terwisscha van Scheltinga, A.F., van der Linden, A.J., Burbach, J.P., Smidt, M.P. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  26. Immunohistochemical evidence for the implication of PC1 in the processing of proneurotensin in rat brain. Villeneuve, P., Seidah, N.G., Beaudet, A. Neuroreport (2000) [Pubmed]
  27. Differential processing of neurotensin/neuromedin N precursor(s) in canine brain and intestine. Carraway, R.E., Mitra, S.P. J. Biol. Chem. (1990) [Pubmed]
  28. The characterization and regional distribution of neuromedin N-like immunoreactivity in rat brain using a highly sensitive and specific radioimmunoassay. Comparison with the distribution of neurotensin. de Nadai, F., Cuber, J.C., Kitabgi, P. Brain Res. (1989) [Pubmed]
  29. Neuromedin N decreases self-stimulation of the medial prefrontal cortex. Ferrer, J.M., Sabater, R., Sáez, J.A. Neuroreport (1992) [Pubmed]
  30. Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord. Minamino, N., Kangawa, K., Matsuo, H. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  31. Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation. Ernst, A., Hellmich, S., Bergmann, A. Peptides (2006) [Pubmed]
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