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Chemical Compound Review

Kinevac     3-[(1-aminocarbonyl-2- phenyl...

Synonyms: Sincalida, Sincalide, Sincalidum, CHEBI:202357, AC1L1OGF, ...
 
 
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Disease relevance of Kinevac

 

High impact information on Kinevac

 

Chemical compound and disease context of Kinevac

 

Biological context of Kinevac

  • For chronic acalculous gallbladder disease, calculation of a gallbladder ejection fraction during sincalide cholescintigraphy can confirm the clinical diagnosis and has become a common routine procedure in many nuclear medicine clinics [11].
  • A cholecystagogue, sincalide, did not prevent the false-positive features which presumably are due to altered bile flow kinetics related to alcoholism and parenteral nutrition [12].
 

Anatomical context of Kinevac

 

Associations of Kinevac with other chemical compounds

 

Gene context of Kinevac

  • Pentagastrin, sincalide and caerulein induced a slight but significant hypocalcaemia and a rise of serum CT levels, together with a significant increase of serum PTH [21].
  • The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel [22].
  • The current study involves an investigation of the possible neurotransmitter systems involved in the ability of exogenously administered sincalide (cholecystokinin octapeptide, CCK-8) to suppress feeding [23].
  • The antagonistic effect of sincalide on morphine was mainly mediated by CCK-A receptor [24].
 

Analytical, diagnostic and therapeutic context of Kinevac

References

  1. Corn oil emulsion: a simple cholecystagogue for diagnosis of chronic acalculous cholecystitis. Bartel, T.B., Juweid, M.E., Ponto, J.A., Graham, M.M. J. Nucl. Med. (2005) [Pubmed]
  2. Normal values for sincalide cholescintigraphy: comparison of two methods. Ziessman, H.A., Muenz, L.R., Agarwal, A.K., ZaZa, A.A. Radiology. (2001) [Pubmed]
  3. Treatment of vincristine-induced ileus with sincalide, a cholecystokinin analog. Jackson, D.V., Wu, W.C., Spurr, C.L. Cancer Chemother. Pharmacol. (1982) [Pubmed]
  4. The role of sincalide cholescintigraphy in the evaluation of patients with acalculus gallbladder disease. Pickleman, J., Peiss, R.L., Henkin, R., Salo, B., Nagel, P. Archives of surgery (Chicago, Ill. : 1960) (1985) [Pubmed]
  5. Normal findings in oral and cholecystokinin cholecystography. Nathan, M.H., Newman, A., Murray, D.J. JAMA (1978) [Pubmed]
  6. Cholecystokinin cholescintigraphy: methodology and normal values using a lactose-free fatty-meal food supplement. Ziessman, H.A., Jones, D.A., Muenz, L.R., Agarval, A.K. J. Nucl. Med. (2003) [Pubmed]
  7. Sincalide-augmented quantitative hepatobiliary scintigraphy (QHBS): definition of normal parameters and preliminary relationship between QHBS and sphincter of Oddi (SO) manometry in patients suspected of having SO dysfunction. Drane, W.E., Johnson, D.A. J. Nucl. Med. (1990) [Pubmed]
  8. Gastroesophageal reflux demonstrated by hepatobiliary imaging in scleroderma. Sawaf, N.W., Orzel, J.A., Weiland, F.L. J. Nucl. Med. (1987) [Pubmed]
  9. Intravenous cholecystokinin octapeptide: its effect on the sonographic appearance of the file ducts in normal subjects. Fein, A.B., Rauch, R.F., Bowie, J.D., Halvorsen, R.A., Rosenberg, E.R. Radiology. (1984) [Pubmed]
  10. Sincalide in patients with parenteral nutrition-associated gallbladder disease. Prescott, W.A., Btaiche, I.F. The Annals of pharmacotherapy. (2004) [Pubmed]
  11. Functional hepatobiliary disease: chronic acalculous gallbladder and chronic acalculous biliary disease. Ziessman, H.A. Seminars in nuclear medicine. (2006) [Pubmed]
  12. PIPIDA scintigraphy for cholecystitis: false positives in alcoholism and total parenteral nutrition. Shuman, W.P., Gibbs, P., Rudd, T.G., Mack, L.A. AJR. American journal of roentgenology. (1982) [Pubmed]
  13. Sincalide-aided ultrasonography of the common bile duct as a predictor of biliary obstruction determined by ERCP and biliary manometry. Aronchick, C.A., Ritchie, W.G., Kaplan, S.M., Wright, S.H., Retig, J.N., Lipshutz, W.H. Gastrointest. Endosc. (1990) [Pubmed]
  14. Increased phospholipid synthesis in the stimulated rat and human pancreas. Chapman, B.A., Wilson, J.S., Colley, P.W., Pirola, R.C., Somer, J.B. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  15. New scintigraphic method for the quantitative measurement of enterogastric reflux. Svedberg, J.B., Karlqvist, P.A., Lindström, E., Sjödahl, R. Scand. J. Gastroenterol. (1984) [Pubmed]
  16. Failure of beta-adrenergic stimulation to affect cholecystokinin-stimulated sigmoid motility in man. Lyrenäs, E., Abrahamsson, H., Dotevall, G. Scand. J. Gastroenterol. (1985) [Pubmed]
  17. Effect of atropine and sincalide on the intestinal uptake of F-18 fluorodeoxyglucose. Jadvar, H., Schambye, R.B., Segall, G.M. Clinical nuclear medicine. (1999) [Pubmed]
  18. L-365,260 reversed effect of sincalide against morphine on electrical and mechanical activities of rat duodenum in vitro. Yang, C.X., Xu, M.Y., Liu, F.Y., Yang, D.X., Wang, S.Z. Acta Pharmacol. Sin. (2002) [Pubmed]
  19. Normal gallbladder ejection fraction after morphine augmentation. Achong, D.M., Oates, E. Clinical nuclear medicine. (1999) [Pubmed]
  20. Effect of succinyl cholecystokinin heptapeptide on synaptosomal 45Ca uptake of mouse hippocampus. Zheng, Y.L., Zhang, W.N., Wu, F.M., Wang, X.C., Chen, J.H. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1995) [Pubmed]
  21. Effect of exogenous gastrointestinal peptides containing the C-terminal tetrapeptide of gastrin on calcium, calcitonin and parathormone serum levels in man. Vantini, I., Cominacini, L., Piubello, W., Ghidini, O., Fattovich, G., Ederle, A., Benini, L., Cocchetto, R., Cavallini, G., LoCascio, V., Scuro, L.A. Hepatogastroenterology (1981) [Pubmed]
  22. Eating, drinking and temperature responses to intracerebroventricular cholecystokinin in the chick. Denbow, D.M., Myers, R.D. Peptides (1982) [Pubmed]
  23. Pharmacological manipulation of sincalide (CCK-8)-induced suppression of feeding. Wilson, M.C., Denson, D., Bedford, J.A., Hunsinger, R.N. Peptides (1983) [Pubmed]
  24. Devazepide reversed effect of sincalide against morphine on rat jejunal activities. Xu, M.Y., Yang, X.P., Jin, H.B., Yang, C.X., Yang, L.Z. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1999) [Pubmed]
  25. Studies of gallbladder contraction using intramuscular sincalide. Rosenquist, C.J., Barcia, T.C. Radiology. (1983) [Pubmed]
  26. Cholecystokinin sonography: lack of utility in diagnosis of acute acalculous cholecystitis. Raduns, K., McGahan, J.P., Beal, S. Radiology. (1990) [Pubmed]
  27. Role of cholecystokinetic agents in 99mTc-IDA cholescintigraphy. Freeman, L.M., Sugarman, L.A., Weissmann, H.S. Seminars in nuclear medicine. (1981) [Pubmed]
  28. Lyophilization of sincalide and correlation of headspace relative humidity with product stability. Huber, R.C., Niedermayer, A.O., Weiss, A.L. Journal of pharmaceutical sciences. (1978) [Pubmed]
 
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