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Chemical Compound Review

Iotrolum     2,4,6-triiodo-5-[methyl-[2- [methyl-[2,4,6...

Synonyms: Osmovist, iotrolan, Iotrovist, Isovist, Iotrol, ...
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Disease relevance of C13177


Psychiatry related information on C13177

  • Intracranial iotrolan distribution following cervical myelography. Postmyelographic registration of adverse effects, psychometric assessment and electroencephalographic recording [6].

High impact information on C13177


Chemical compound and disease context of C13177


Biological context of C13177


Anatomical context of C13177

  • A dose of 300 mg I/kg injected into a permanently cannulated lateral ventricle produced neurofunctional deficits with all contrast media except DL-3-117, which scored equal to Ringer's solution [13].
  • On the basis of these findings, iotrol holds promise as a clinical contrast material for the subarachnoid space [17].
  • Following animal sacrifice, histologic examination of the synovium revealed a significant difference in the inflammatory response evoked by the contrast agents: Iotrol caused less inflammation [18].
  • Iotrol is cleared from the cerebrospinal fluid and excreted by glomerular filtration within the same time range as other water-soluble contrast media [19].
  • Both osmolarity and chemotoxicity contribute to the greater vasorelaxant effect on swine renal artery of monomeric contrast media when compared to that of the nonionic dimeric contrast medium, iotrolan [14].

Associations of C13177 with other chemical compounds


Gene context of C13177

  • Iotrol, a new myelographic agent: 1. Radiography, CT, CSF clearance, and brain penetration [23].
  • We did not observe statistically significant differences in comparing iotrolan and iopromid concerning ERCP/EST-induced pancreatic damage [5].
  • The rare finding of strong periventricular enhancement was observed by means of intraoperative CT cisternography using Iotrolan in a one-month-old boy with Dandy-Walker syndrome associated with occipital cephalocele [24].

Analytical, diagnostic and therapeutic context of C13177


  1. A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root. Brouwers, P.J., Kottink, E.J., Simon, M.A., Prevo, R.L. Pain (2001) [Pubmed]
  2. Safety and pharmacokinetics of iotrolan in hysterosalpingography. Retention and irritability compared with Lipiodol. Miyamoto, Y., Tsujimoto, T., Iwai, K., Ishida, K., Uchimoto, R., Miyazawa, T., Azuma, H. Investigative radiology. (1995) [Pubmed]
  3. Aseptic meningitis complicating iotrolan myelography. Nakakoshi, T., Moriwaka, F., Tashiro, K., Nakane, K., Miyasaka, K. AJNR. American journal of neuroradiology. (1991) [Pubmed]
  4. Encephalopathy and rhabdomyolysis induced by iotrolan during epiduroscopy: [Encephalopathie et rhabdomyolyse provoquees par l'iotrolan durant l'epiduroscopie]. Mizuno, J., Gauss, T., Suzuki, M., Hayashida, M., Arita, H., Hanaoka, K. Canadian journal of anaesthesia = Journal canadien d'anesth??sie (2007) [Pubmed]
  5. Frequency of pancreatitis after endoscopic retrograde cholangiopancreatography with iopromid or iotrolan: a randomized trial. Goebel, C., Hardt, P., Doppl, W., Temme, H., Hackstein, N., Klör, H.U. European radiology. (2000) [Pubmed]
  6. Intracranial iotrolan distribution following cervical myelography. Postmyelographic registration of adverse effects, psychometric assessment and electroencephalographic recording. Fiirgaard, B., Madsen, H.H., Svare, U., Eriksen, F.B., Skjødt, T., Zeeberg, I. Acta radiologica (Stockholm, Sweden : 1987) (1995) [Pubmed]
  7. Bosentan, an orally active endothelin antagonist: effect on the renal response to contrast media. Oldroyd, S.D., Haylor, J.L., Morcos, S.K. Radiology. (1995) [Pubmed]
  8. Knee arthrography: comparison of iotrolan and ioxaglate sodium meglumine. Obermann, W.R., Bloem, J.L., Hermans, J. Radiology. (1989) [Pubmed]
  9. Iotrol versus metrizamide in lumbar myelography: a double-blind study. Malnor, M.D., Houston, L.W., Strother, C.M., Turski, P.A., Sackett, J.F., Boyer, M. Radiology. (1986) [Pubmed]
  10. The effect of contrast media on the synovial membrane. Papacharalampous, X., Patsouris, E., Mundinger, A., Beck, A., Kouloulias, V., Primetis, E., Koureas, A., Vlahos, L. European journal of radiology. (2005) [Pubmed]
  11. Contrast media-induced ventricular fibrillation: an experimental study of the effects of dimeric contrast media during wedged catheter injection in dogs. Pedersen, H.K., Jacobsen, E.A., Refsum, H. Academic radiology. (1994) [Pubmed]
  12. Effects of radiographic contrast media on pulmonary vascular resistance of normoxic and chronically hypoxic pulmonary hypertensive rats. Emery, C.J., Fang, L., Laude, E.A., Morcos, S.K. The British journal of radiology. (2001) [Pubmed]
  13. Nonionic dimer: development and initial testing of an intrathecal contrast agent. Sovak, M., Ranganathan, R., Speck, U. Radiology. (1982) [Pubmed]
  14. Effects of dimeric radiographic contrast medium iotrolan on Swine renal arteries: comparison with monomeric contrast media iohexol and iomeprol. Heinrich, M., Schneider, G., Grgic, A., Humke, U., Kramann, B., Uder, M. Investigative radiology. (2004) [Pubmed]
  15. The effect of radiographic contrast media on leukocyte motility. Roobottom, C.A., Farrow, R., Wells, I.P., Hurlock-Fimls, N. Investigative radiology. (1994) [Pubmed]
  16. Tissue distribution and excretion of iotrolan after intravenous and suboccipital injections in animals. Weinmann, H.J., Scholz, P., Mützel, W. Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin. Ergänzungsband. (1989) [Pubmed]
  17. Iotrol, a new myelographic agent: 2. Comparative electroencephalographic evaluation by spectrum analysis. Sovak, M., Ranganathan, R., Kerber, C.W., Bickford, R., Alksne, J.F. AJNR. American journal of neuroradiology. (1983) [Pubmed]
  18. Investigation of a new arthrographic contrast agent: Iotrol. Guerra, J., Resnick, D., Haghighi, P., Sovak, M., Cone, R. Investigative radiology. (1984) [Pubmed]
  19. Clinical trial of iotrol for lumbar myelography. Skutta, T., Vogelsang, H., Galanski, M., Hammer, B., Weinmann, H.J. AJNR. American journal of neuroradiology. (1983) [Pubmed]
  20. Animal experimental myelography in the pig. A comparison between iohexol and iotrolan. Skalpe, I.O., Tang, G.J. Investigative radiology. (1995) [Pubmed]
  21. Effects of angiographic contrast media on venous endothelium of rabbits. Thiesen, B., Mützel, W. Investigative radiology. (1990) [Pubmed]
  22. Cytokine profiles after nonionic dimeric contrast medium injection. Böhm, I., Speck, U., Schild, H. Investigative radiology. (2003) [Pubmed]
  23. Iotrol, a new myelographic agent: 1. Radiography, CT, CSF clearance, and brain penetration. Kerber, C.W., Sovak, M., Ranganathan, R.S., Heilman, C.B. AJNR. American journal of neuroradiology. (1983) [Pubmed]
  24. Periventricular enhancement following intraoperative CT cisternography in a patient with Dandy-Walker syndrome. Case report. Koyama, T., Okudera, H., Tada, T., Wada, N., Kobayashi, S. Neurosurgical review. (1997) [Pubmed]
  25. Bronchography with iotrolan 300. Morcos, S.K., Anderson, P.B. Radiology. (1995) [Pubmed]
  26. Use of iotrolan versus ethiodized poppy-seed oil in hysterosalpingography. Lindequist, S., Rasmussen, F., Larsen, C. Radiology. (1994) [Pubmed]
  27. Suitability of and tolerance to Iotrolan 300 in bronchography via the fibreoptic bronchoscope. Morcos, S.K., Anderson, P.B., Baudouin, S.V., Clout, C., Fairlie, N., Baudouin, C., Warnock, N. Thorax (1990) [Pubmed]
  28. Production and characterization of improved liposomes containing radiographic contrast media. Adzamli, I.K., Seltzer, S.E., Slifkin, M., Blau, M., Adams, D.F. Investigative radiology. (1990) [Pubmed]
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