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Gene Review

PSPH  -  phosphoserine phosphatase

Homo sapiens

Synonyms: L-3-phosphoserine phosphatase, O-phosphoserine phosphohydrolase, PSP, PSPHD, PSPase, ...
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Disease relevance of PSPH


Psychiatry related information on PSPH


High impact information on PSPH


Chemical compound and disease context of PSPH


Biological context of PSPH


Anatomical context of PSPH

  • Further investigation showed that the phosphoserine phosphatase (EC activity in lymphoblasts and fibroblasts amounted to about 25% of normal values [1].
  • The presence of low frequency drives (< 4 Hz) in the bilateral PSP condition and its absence in the bilateral FDI condition is consistent with a bilateral drive to axial, but not distal, musculature by the motor pathways responsible for this oscillatory input [19].
  • These results demonstrate mitogenic activity in germ cell proteins (RSP and PSP) and identify a NGF-like protein(s) which is associated with most of this activity [20].
  • Furthermore, neurite outgrowth from pheochromocytoma cells (PC-12), a functional bioassay for NGF-like activity, was stimulated by addition of RSP and PSP to the culture media of the PC-12 cells [20].
  • A homology cloning approach targeting conserved motifs present in all serine proteases, was used to identify candidate serine proteases involved in these processes, and revealed 5 genes (acrosin, testisin, neurosin, PSP and neurotrypsin), none of which had been associated previously with expression in endothelial cells [21].

Associations of PSPH with chemical compounds


Other interactions of PSPH


Analytical, diagnostic and therapeutic context of PSPH


  1. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. Jaeken, J., Detheux, M., Fryns, J.P., Collet, J.F., Alliet, P., Van Schaftingen, E. J. Med. Genet. (1997) [Pubmed]
  2. Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase. Minelli, A., Piantanida, M., Maserati, E., Campagnoli, E., Pasquali, F., Danesino, C. Genes Chromosomes Cancer (1990) [Pubmed]
  3. Enzyme pathology of human mesotheliomas. Greengard, O., Head, J.F., Chahinian, A.P., Goldberg, S.L. J. Natl. Cancer Inst. (1987) [Pubmed]
  4. A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion. Tribble, G.D., Mao, S., James, C.E., Lamont, R.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. The H1c haplotype at the MAPT locus is associated with Alzheimer's disease. Myers, A.J., Kaleem, M., Marlowe, L., Pittman, A.M., Lees, A.J., Fung, H.C., Duckworth, J., Leung, D., Gibson, A., Morris, C.M., de Silva, R., Hardy, J. Hum. Mol. Genet. (2005) [Pubmed]
  6. Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies. Ramakrishnan, P., Dickson, D.W., Davies, P. Neurobiol. Dis. (2003) [Pubmed]
  7. Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration. Mochizuki-Kawai, H., Kawamura, M., Hasegawa, Y., Mochizuki, S., Oeda, R., Yamanaka, K., Tagaya, H. Neuropsychologia. (2004) [Pubmed]
  8. Non-Fluent Progressive Aphasia, Depression, and OCD in a Woman With Progressive Supranuclear Palsy: Neuroanatomical and Neuropathological Correlations. Karnik, N.S., D'Apuzzo, M., Greicius, M. Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology (2006) [Pubmed]
  9. Development of a multi-channel exploratory battery for psychophysiological assessment: the Stress Profile. Diaz, M.I., Vallejo, M.A., Comeche, M.I. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2003) [Pubmed]
  10. Structure and mechanism of the phosphotyrosyl phosphatase activator. Chao, Y., Xing, Y., Chen, Y., Xu, Y., Lin, Z., Li, Z., Jeffrey, P.D., Stock, J.B., Shi, Y. Mol. Cell (2006) [Pubmed]
  11. Effect of carboxylate-binding mode on metal binding/selectivity and function in proteins. Dudev, T., Lim, C. Acc. Chem. Res. (2007) [Pubmed]
  12. Postsynaptic modulation of rectifying electrical synaptic inputs to the LG escape command neuron in crayfish. Edwards, D.H., Heitler, W.J., Leise, E.M., Fricke, R.A. J. Neurosci. (1991) [Pubmed]
  13. The undifferentiated enzymic composition of human fetal lung and pulmonary tumors. Greengard, O., Herzfeld, A. Cancer Res. (1977) [Pubmed]
  14. Mechanistic studies of phosphoserine phosphatase, an enzyme related to P-type ATPases. Collet, J.F., Stroobant, V., Van Schaftingen, E. J. Biol. Chem. (1999) [Pubmed]
  15. 2-phosphoglycerate phosphatase and serine biosynthesis in Veillonella alcalescens. Pestka, J.J., Delwiche, E.A. Can. J. Microbiol. (1981) [Pubmed]
  16. Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor. Li, X.Y., Wang, J.F., Zhu, P.P., Liu, L., Ge, J.B., Yang, S.X. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1990) [Pubmed]
  17. Assignment of the human phosphoserine phosphatase gene (PSP) to the pter leads to q22 region of chromosome 7. Koch, G.A., Eddy, R.L., Haley, L.L., Byers, M.G., McAvoy, M., Shows, T.B. Cytogenet. Cell Genet. (1983) [Pubmed]
  18. Natural history of chronic mitral insufficiency: relation of peak systolic pressure/end-systolic volume ratio to morbidity and mortality. Ramanathan, K.B., Knowles, J., Connor, M.J., Tribble, R., Kroetz, F.W., Sullivan, J.M., Mirvis, D.M. J. Am. Coll. Cardiol. (1984) [Pubmed]
  19. The unilateral and bilateral control of motor unit pairs in the first dorsal interosseous and paraspinal muscles in man. Marsden, J.F., Farmer, S.F., Halliday, D.M., Rosenberg, J.R., Brown, P. J. Physiol. (Lond.) (1999) [Pubmed]
  20. Germ cell mitogenic activity is associated with nerve growth factor-like protein(s). Onoda, M., Pflug, B., Djakiew, D. J. Cell. Physiol. (1991) [Pubmed]
  21. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Aimes, R.T., Zijlstra, A., Hooper, J.D., Ogbourne, S.M., Sit, M.L., Fuchs, S., Gotley, D.C., Quigley, J.P., Antalis, T.M. Thromb. Haemost. (2003) [Pubmed]
  22. A new class of phosphotransferases phosphorylated on an aspartate residue in an amino-terminal DXDX(T/V) motif. Collet, J.F., Stroobant, V., Pirard, M., Delpierre, G., Van Schaftingen, E. J. Biol. Chem. (1998) [Pubmed]
  23. Genetical and biochemical studies on human phosphoserine phosphatase. Moro-Furlani, A.M., Turner, V.S., Hopkinson, D.A. Ann. Hum. Genet. (1980) [Pubmed]
  24. Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J., Farquharson, C. Protein Eng. (2003) [Pubmed]
  25. Enzyme activities in human fetal and neoplastic tissues. Herzfeld, A., Greengard, O. Cancer (1980) [Pubmed]
  26. Okadaic acid induces both augmentation and inhibition of opsonized zymosan-stimulated superoxide production by differentiated HL-60 cells. Possible involvement of dephosphorylation of a cytosolic 21K protein in respiratory burst. Suzuki, K., Yamaguchi, T., Oshizawa, T., Yamamoto, Y., Nishimaki-Mogami, T., Hayakawa, T., Takahashi, A. Biochim. Biophys. Acta (1995) [Pubmed]
  27. Purification, crystallization and preliminary X-ray diffraction analysis of human phosphoserine phosphatase. Peeraer, Y., Rabijns, A., Verboven, C., Collet, J.F., Van Schaftingen, E., De Ranter, C. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  28. Relationship between insulin response to oral glucose load and creatinine clearance. Yasuda, K., Sato, T., Furuyama, T., Yashinaga, K. Diabetes (1975) [Pubmed]
  29. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray. Zeng, F., Hon, C.C., Sit, W.H., Chow, K.Y., Hui, R.K., Law, I.K., Ng, V.W., Yang, X.T., Leung, F.C., Wan, J.M. Int. J. Oncol. (2005) [Pubmed]
  30. Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax. Czerny, M., Salat, A., Fleck, T., Hofmann, W., Zimpfer, D., Eckersberger, F., Klepetko, W., Wolner, E., Mueller, M.R. Ann. Thorac. Surg. (2004) [Pubmed]
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