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Chemical Compound Review

AC1L9QF5     (2S)-N-[(2S)-1-[(2S)-2...

Synonyms: pGlu-His-ProNH2
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Disease relevance of Rifathyroin


High impact information on Rifathyroin


Chemical compound and disease context of Rifathyroin


Biological context of Rifathyroin


Anatomical context of Rifathyroin

  • Thyrotropin-releasing factor (TRF) activity was higher after 2 and 24 h of cold exposure in the median eminence and after 8 h in the anterior hypothalamus-preoptic area, but lower after 8 and 24 h in the dorsomedial hypothalamus [16].
  • These results suggest that most, if not all of the thyrotropin-releasing factor (TRF) necessary for normal TSH secretion in resting conditions or during the hypothyroid state, is produced and released in the median eminence-arcuate nucleus area, the adequate activity of which, in turn, depends on intact connections with the anterior hypothalamus [17].
  • An increase in the TI/TTOT ratio but (unaffected) VT/TI ratio indicates that thyrotropic releasing hormone affects "respiratory timing" mechanisms rather than "inspiratory drive." The changes in respiratory parameters are most probably due to an effect on the central respiratory controlling centers in the brain stem [13].
  • In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development [18].
  • Metabolism of thyrotropin releasing factor in two clonal cell lines of nervous system origin [19].

Associations of Rifathyroin with other chemical compounds


Gene context of Rifathyroin


Analytical, diagnostic and therapeutic context of Rifathyroin


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