Disease relevance of HOMATROPINE

• Twenty milligrams of buspirone reduced the mydriasis induced by pretreatment with homatropine eyedrops [1].
• Miosis and exophoria were increased in a dose-related manner by hydrocodone/homatropine [2].
• Transcutaneous electrical stimulation applied to the infratrochlear nerve induces a homatropine-resistant miosis in humans [3].
• Benztropine, homatropine and hyoscyamine caused hypotension and produced alpha-adrenergic receptor blockade similar to atropine [4].
• Systemic toxicity from ocular homatropine [5].

Psychiatry related information on HOMATROPINE

• Cognitive and psychomotor impairment were more marked with lorazepam than with hydrocodone/homatropine and morphine [2].
• Homatropine eyedrops change sleep and mood disorders in depressive patients [6].

High impact information on HOMATROPINE

• Reduction in plasma prolactin levels in depressed women after homatropine administration [7].
• An electrogenerated chemiluminescence (ECL) method for the determination of pethidine, atropine, homatropine and cocaine is described [8].
• The binding of [3H]ACh to endothelial membranes was displacable by nanomolar concentrations of scopolamine but only by micromolar concentrations of atropine and homatropine [9].
• The reverse was true for smooth muscle membranes, i.e. [3H]ACh binding was displacable by nanomolar concentrations of atropine and homatropine but only by micromolar concentrations of scopolamine [9].
• On further questioning of family members, it was discovered that she was being treated for anterior uveitis with 5% homatropine [5].

Chemical compound and disease context of HOMATROPINE

• Local instillation of thymoxamine eye drops (0-1%) completely reversed the mydriasis produced by ephedrine (5%) but not that produced by ephedrine (5%) together with homatropine (0-5%) [10].
• One of us (J. C. O'D.) compared homatropine methylbromide plus phenobarbital in a 20% alcohol solution, and all of the individual components of that solution, to see which was most effective in the symptomatic relief of colic [11].
• The 35-year-old man, demonstrating auricular chondritis, arthritis, nasal cartilage involvement, episcleritis and respiratory tract chondritis, was admitted to the hospital and treated with 60 mg of prednisone daily, prednisolone acetate 1% ophthalmic drops every waking hour and homatropine hydrobromide 5% ophthalmic drops twice daily [12].
• This paper describes an unusual case in which deafness developed while the patient was receiving topical therapy with prednisolone and homatropine for mild bilateral iritis and right-sided nodular episcleritis [13].

Biological context of HOMATROPINE

• Contrast sensitivity was measured in 12 subjects for different spatial frequencies of sinusoidal grating patterns, generated by oscilloscope, for pupil diameters 2-8 mm and for defocus of +1-4 D, following homatropine eyedrops [14].
• Nasal administration of homatropine or pilocarpine had no effect on the air conditioning [15].
• For the parameters, area under pupil diameter--time curve (AUC) and maximum pupillary response (MPR), a linear relationship exists between response to homatropine and urea concentration [16].

Anatomical context of HOMATROPINE

• RESULTS: In the parameters showing the changes of the anterior chamber angle after topical use of 2% homatropine solution, both the trabecular iris angle and the angle opening distance 250 decreased [17].

Associations of HOMATROPINE with other chemical compounds

• METHODS: Eighteen volunteers participated in a crossover, double-blind study in which they received placebo; 5 mg hydrocodone/1.5 mg homatropine, 10 mg hydrocodone/3 mg homatropine, 20 mg hydrocodone/6 mg homatropine (all PO); 40 mg morphine (PO); and 2 mg lorazepam (PO) [2].
• The purpose of this study was to demonstrate the time of onset, peak effect and its duration of action as well as shallowing/deepening of the anterior chamber, after single instillation of pilocarpine 2% or homatropine bromide 2%, topically in one eye [18].
• We compared the cycloplegic effects of cyclopentolate, homatropine and atropine by the retinoscopy findings and residual accommodation left following their use in the same individual [19].
• Sweat function test, valsalva manoeuvre, Histamine triple response, cold pressor test and Homatropine instillation were carried out in twenty normal healthy volunteers (controls) and the (ENL) patients [20].

Gene context of HOMATROPINE

• The effects of homatropine and atropine on plasma LH and prolactin (PRL) levels during the afternoon of pro-oestrus were investigated [21].
• The ability of SP to modify the mydriasis induced by pretreatment with 1% homatropine eyedrops was also studied [22].

Analytical, diagnostic and therapeutic context of HOMATROPINE

• Positive diagnosis of self-medication with homatropine eye drops [23].
• The time course of this pupillary constriction was similar to that seen without the influence of homatropine [3].
• 3. In 11 healthy subjects, the pupillary response to transcutaneous electrical stimulation was evaluated during iris parasympathetic blockade induced by homatropine eyedrops [3].
• 4. A reduction in the pupillary size followed the electrical stimulation, still under the effect of homatropine which abolished the light reflex [3].
• Anticholinergic delirium caused by topical homatropine ophthalmologic solution: confirmation by anticholinergic radioreceptor assay in two cases [24].

References