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Chemical Compound Review

Homatropin     [(1R,5S)-8-methyl-8- azabicyclo[3.2.1]oct-3...

Synonyms: Omatropina, HOMATROPINE, Homotropine, Homoatropine, DL-HOMATROPINE, ...
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Disease relevance of HOMATROPINE


Psychiatry related information on HOMATROPINE


High impact information on HOMATROPINE


Chemical compound and disease context of HOMATROPINE

  • Local instillation of thymoxamine eye drops (0-1%) completely reversed the mydriasis produced by ephedrine (5%) but not that produced by ephedrine (5%) together with homatropine (0-5%) [10].
  • One of us (J. C. O'D.) compared homatropine methylbromide plus phenobarbital in a 20% alcohol solution, and all of the individual components of that solution, to see which was most effective in the symptomatic relief of colic [11].
  • The 35-year-old man, demonstrating auricular chondritis, arthritis, nasal cartilage involvement, episcleritis and respiratory tract chondritis, was admitted to the hospital and treated with 60 mg of prednisone daily, prednisolone acetate 1% ophthalmic drops every waking hour and homatropine hydrobromide 5% ophthalmic drops twice daily [12].
  • This paper describes an unusual case in which deafness developed while the patient was receiving topical therapy with prednisolone and homatropine for mild bilateral iritis and right-sided nodular episcleritis [13].

Biological context of HOMATROPINE

  • Contrast sensitivity was measured in 12 subjects for different spatial frequencies of sinusoidal grating patterns, generated by oscilloscope, for pupil diameters 2-8 mm and for defocus of +1-4 D, following homatropine eyedrops [14].
  • Nasal administration of homatropine or pilocarpine had no effect on the air conditioning [15].
  • For the parameters, area under pupil diameter--time curve (AUC) and maximum pupillary response (MPR), a linear relationship exists between response to homatropine and urea concentration [16].

Anatomical context of HOMATROPINE

  • RESULTS: In the parameters showing the changes of the anterior chamber angle after topical use of 2% homatropine solution, both the trabecular iris angle and the angle opening distance 250 decreased [17].

Associations of HOMATROPINE with other chemical compounds

  • METHODS: Eighteen volunteers participated in a crossover, double-blind study in which they received placebo; 5 mg hydrocodone/1.5 mg homatropine, 10 mg hydrocodone/3 mg homatropine, 20 mg hydrocodone/6 mg homatropine (all PO); 40 mg morphine (PO); and 2 mg lorazepam (PO) [2].
  • The purpose of this study was to demonstrate the time of onset, peak effect and its duration of action as well as shallowing/deepening of the anterior chamber, after single instillation of pilocarpine 2% or homatropine bromide 2%, topically in one eye [18].
  • We compared the cycloplegic effects of cyclopentolate, homatropine and atropine by the retinoscopy findings and residual accommodation left following their use in the same individual [19].
  • Sweat function test, valsalva manoeuvre, Histamine triple response, cold pressor test and Homatropine instillation were carried out in twenty normal healthy volunteers (controls) and the (ENL) patients [20].

Gene context of HOMATROPINE


Analytical, diagnostic and therapeutic context of HOMATROPINE


  1. Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control. Fanciullacci, M., Sicuteri, R., Alessandri, M., Geppetti, P. Clin. Pharmacol. Ther. (1995) [Pubmed]
  2. Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. Zacny, J.P. Psychopharmacology (Berl.) (2003) [Pubmed]
  3. Transcutaneous electrical stimulation applied to the infratrochlear nerve induces a homatropine-resistant miosis in humans. Fusco, B.M., Alessandri, M., Campagnolo, V., Fanciullacci, M. Clin. Sci. (1990) [Pubmed]
  4. Structure-activity requirements for hypotension and alpha-adrenergic receptor blockade by analogues of atropine. Cantor, E.H., Abraham, S., Marcum, E.A., Spector, S. Eur. J. Pharmacol. (1983) [Pubmed]
  5. Systemic toxicity from ocular homatropine. Reilly, K.M., Chan, L., Mehta, N.J., Salluzzo, R.F. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. (1996) [Pubmed]
  6. Homatropine eyedrops change sleep and mood disorders in depressive patients. Stojek, A., Bilikiewicz, A., Bartkiewicz, T., Morstyn, J. Psychiatr. Pol. (1987) [Pubmed]
  7. Reduction in plasma prolactin levels in depressed women after homatropine administration. Stojek, A., Bilikiewicz, A., Szewzyk, S., Bartkiewicz, T. The American journal of psychiatry. (1986) [Pubmed]
  8. Tris(2,2'-bipyridine)ruthenium(II) electrogenerated chemiluminescence of alkaloid type drugs with solid phase extraction sample preparation. Song, Q., Greenway, G.M., McCreedy, T. The Analyst. (2001) [Pubmed]
  9. Atropine- and scopolamine-resistant subtypes of muscarinic receptors in the rabbit aorta. Manjeet, S., Sim, M.K. Eur. J. Pharmacol. (1989) [Pubmed]
  10. Influence of thymoxamine on changes in pupil diameter and accommodation produced by homatropine and ephedrine. Small, S., Stewart-Jones, J.H. The British journal of ophthalmology. (1976) [Pubmed]
  11. The failure of conventional drug therapy in the management of infantile colic. O'Donovan, J.C., Bradstock, A.S. Am. J. Dis. Child. (1979) [Pubmed]
  12. Relapsing polychondritis in a Latin American man. Waller, E.S., Raebel, M.A. American journal of hospital pharmacy. (1979) [Pubmed]
  13. Cogan's syndrome: a treatable cause of neurosensory deafness. Bachynski, B., Wise, J. Can. J. Ophthalmol. (1984) [Pubmed]
  14. A quantitative investigation into the effects of pupil diameter and defocus on contrast sensitivity for an extended range of spatial frequencies in natural and homatropinized eyes. Kay, C.D., Morrison, J.D. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (1987) [Pubmed]
  15. Measurements of the air conditioning capacity of the nose during normal and pathological conditions and pharmacological influence. Drettner, B., Falck, B., Simon, H. Acta Otolaryngol. (1977) [Pubmed]
  16. Effect of urea on the activity of certain ophthalmic drugs in man. El-Nimr, A.E., Salama, H.A., Khalil, R.M., Kassem, M.A. Die Pharmazie. (1983) [Pubmed]
  17. Ultrasound biomicroscopic study on changes of ocular anterior segment structure after topical application of cycloplegia. Wang, T., Liu, L., Li, Z., Hu, S., Yang, W., Zhu, X. Chin. Med. J. (1999) [Pubmed]
  18. Ultrasonic study to see the effect of topical pilocarpine and homatropine on anterior chamber depth in phakic cases. Mehrotra, A.S., Gupta, I.L., Chouhan, B.S. Indian journal of ophthalmology. (1992) [Pubmed]
  19. Status of cyclopentolate as a cycloplegic in children: a comparison with atropine and homatropine. Khurana, A.K., Ahluwalia, B.K., Rajan, C. Acta ophthalmologica. (1988) [Pubmed]
  20. Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. Burte, N.P., Chandorkar, A.G., Muley, M.P., Balsara, J.J., Bulakh, P.M. Leprosy in India. (1983) [Pubmed]
  21. Role of the blood-brain barrier in the anticholinergic differential effects on LH and prolactin release in proestrous rats. Donoso, A.O., Bacha, J.C. J. Neural Transm. (1975) [Pubmed]
  22. In vivo pupillary constrictor effects of substance P in man. Alessandri, M., Fusco, B.M., Maggi, C.A., Fanciullacci, M. Life Sci. (1991) [Pubmed]
  23. Positive diagnosis of self-medication with homatropine eye drops. Warrens, A.N., Ron, M.A., Dawling, S. The British journal of psychiatry : the journal of mental science. (1990) [Pubmed]
  24. Anticholinergic delirium caused by topical homatropine ophthalmologic solution: confirmation by anticholinergic radioreceptor assay in two cases. Tune, L.E., Bylsma, F.W., Hilt, D.C. The Journal of neuropsychiatry and clinical neurosciences. (1992) [Pubmed]
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