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Chemical Compound Review

AC1NT0QB     2-[4-[(5S,10S,13R,17R)-3,7- dihydroxy-10,13...

Synonyms:
 
 
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Disease relevance of TAUROCHENODEOXYCHOLIC ACID

 

High impact information on TAUROCHENODEOXYCHOLIC ACID

 

Chemical compound and disease context of TAUROCHENODEOXYCHOLIC ACID

  • RESULTS: Taurochenodeoxycholic acid and chenodeoxycholc acid caused cholestasis and liver damage associated with a decreased bile flow, total and individual bile acids secretion accompanied by a biliary leakage of lactate dehydrogenase and alkaline phosphatase enzymes [8].
 

Biological context of TAUROCHENODEOXYCHOLIC ACID

 

Anatomical context of TAUROCHENODEOXYCHOLIC ACID

 

Associations of TAUROCHENODEOXYCHOLIC ACID with other chemical compounds

 

Gene context of TAUROCHENODEOXYCHOLIC ACID

 

Analytical, diagnostic and therapeutic context of TAUROCHENODEOXYCHOLIC ACID

References

  1. Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the rat. Roda, A., Piazza, F., Baraldini, M., Speroni, E., Guerra, M.C., Cerré, C., Cantelli Forti, G. Hepatology (1998) [Pubmed]
  2. Vasoactive effects of bile salts in cirrhotic rats: in vivo and in vitro studies. Pak, J.M., Lee, S.S. Hepatology (1993) [Pubmed]
  3. Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. Ohiwa, T., Katagiri, K., Hoshino, M., Hayakawa, T., Nakai, T. Hepatology (1993) [Pubmed]
  4. Acute and chronic effects of different bile acids on indomethacin-induced intestinal inflammation. Arndt, H., Kullmann, F., Schölmerich, J., Palitzsch, K.D. Inflammation (1997) [Pubmed]
  5. Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat. Sokol, R.J., McKim, J.M., Goff, M.C., Ruyle, S.Z., Devereaux, M.W., Han, D., Packer, L., Everson, G. Gastroenterology (1998) [Pubmed]
  6. What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis. Maher, J.J. Hepatology (2004) [Pubmed]
  7. Cloning and expression of a pig liver taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily. Lundell, K., Hansson, R., Wikvall, K. J. Biol. Chem. (2001) [Pubmed]
  8. Competition in liver transport between chenodeoxycholic acid and ursodeoxycholic acid as a mechanism for ursodeoxycholic acid and its amidates' protection of liver damage induced by chenodeoxycholic acid. Piazza, F., Montagnani, M., Russo, C., Azzaroli, F., Aldini, R., Roda, E., Roda, A. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2000) [Pubmed]
  9. 7 alpha-Dehydroxylation of bile acids by resting cells of an unidentified, gram-positive, nonsporeforming anaerobic bacterium. Masuda, N., Oda, H. Appl. Environ. Microbiol. (1983) [Pubmed]
  10. Tauroursodeoxycholic acid enhances phagocytosis of the cultured rat Kupffer cell. Funaoka, M., Komatsu, M., Toyoshima, I., Mikami, K., Ono, T., Hoshino, T., Kato, J., Kuramitsu, T., Ishii, T., Masamune, O. J. Gastroenterol. Hepatol. (1999) [Pubmed]
  11. Differential effects between tauroursodeoxycholic and taurochenodeoxycholic acids in hepatic fibrosis: an assessment by primary cultured Ito and Kupffer cells from the rat liver. Sugata, K., Kamimura, S., Shijo, H. J. Gastroenterol. Hepatol. (1996) [Pubmed]
  12. Partial purification and characterization of NAD-dependent 7alpha-hydroxysteroid dehydrogenase from Bacteroides thetaiotaomicron. Sherrod, J.A., Hylemon, P.B. Biochim. Biophys. Acta (1977) [Pubmed]
  13. Characterization of 6 alpha-hydroxylation of taurochenodeoxycholic acid in pig liver. Boström, H. J. Lipid Res. (1986) [Pubmed]
  14. Relationship between bile acid transplacental gradients and transport across the fetal-facing plasma membrane of the human trophoblast. Monte, M.J., Rodriguez-Bravo, T., Macias, R.I., Bravo, P., el-Mir, M.Y., Serrano, M.A., Lopez-Salva, A., Marin, J.J. Pediatr. Res. (1995) [Pubmed]
  15. Characterisation of taurochenodeoxycholic acid 6 alpha-hydroxylase from pig liver microsomes. Araya, Z., Hellman, U., Hansson, R. Eur. J. Biochem. (1995) [Pubmed]
  16. Tauroursodeoxycholic acid is less damaging than taurochenodeoxycholic acid to the gastric and esophageal mucosa. Lillemoe, K.D., Kidder, G.W., Harmon, J.W., Gadacz, T.R., Johnson, L.F., Bunte, R.M., Hofmann, A.F. Dig. Dis. Sci. (1983) [Pubmed]
  17. Modeling plasma lipoprotein-bile lipid relationships: differential impact of psyllium and cholestyramine in hamsters fed a lithogenic diet. Trautwein, E.A., Siddiqui, A., Hayes, K.C. Metab. Clin. Exp. (1993) [Pubmed]
  18. The effect of idebenone, a coenzyme Q analogue, on hydrophobic bile acid toxicity to isolated rat hepatocytes and hepatic mitochondria. Shivaram, K.N., Winklhofer-Roob, B.M., Straka, M.S., Devereaux, M.W., Everson, G., Mierau, G.W., Sokol, R.J. Free Radic. Biol. Med. (1998) [Pubmed]
  19. Vasopressin reduces taurochenodeoxycholate-induced hepatotoxicity by lowering the hepatocyte taurochenodeoxycholate content. Nakazawa, T., Hoshino, M., Hayakawa, T., Tanaka, A., Ohiwa, T. J. Hepatol. (1996) [Pubmed]
  20. Comparison of the binding of various bile acids and bile salts in vitro by several types of fiber. Story, J.A., Kritchevsky, D. J. Nutr. (1976) [Pubmed]
  21. The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver. Botham, K.M., Boyd, G.S. Eur. J. Biochem. (1983) [Pubmed]
  22. 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Araya, Z., Wikvall, K. Biochim. Biophys. Acta (1999) [Pubmed]
  23. Taurochenodeoxycholic acid induced biphasic hepatotoxicity in isolated perfused rat liver: roles of Ca2+ and calpain. Hasegawa, C., Yamada, T., Ohara, H., Nakazawa, T., Sano, H., Ando, H., Kunimatsu, M., Ozaki, Y., Takahashi, S., Nomura, T., Joh, T., Itoh, M. Hepatogastroenterology (2003) [Pubmed]
  24. Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and expression in fetal liver: comparison with expression of taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21). Lundell, K., Wikvall, K. Biochim. Biophys. Acta (2003) [Pubmed]
  25. The effect of neurotensin on the concentration of cholesterol and bile acids in the guinea pig. Peric-Golia, L., Gardner, C.F., Wilson, D.E., Peric-Golia, M. Lipids (1984) [Pubmed]
  26. Oral S-adenosyl-L-methionine (SAMe) administration enhances bile salt conjugation with taurine in patients with liver cirrhosis. Angelico, M., Gandin, C., Nistri, A., Baiocchi, L., Capocaccia, L. Scand. J. Clin. Lab. Invest. (1994) [Pubmed]
 
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