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Chemical Compound Review

AC1NSG01     lead chloride

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Disease relevance of lead chloride


High impact information on lead chloride


Chemical compound and disease context of lead chloride


Biological context of lead chloride


Anatomical context of lead chloride

  • Lead chloride, at concentrations of 67 muM in the incubation media, inhibits the potassium-stimulated respiration (3 to 30mM increase in K+) of rat cerebral cortex slices [15].
  • Human blood platelet aggregation and the formation of icosanoids were studied in response to triethyl lead chloride (Et3PbCl) [16].
  • This experiment was performed to investigate changes in the thymus of Wistar-strain male rats administered cadmium chloride (CdCl2), mercuric chloride (HgCl2), and lead chloride (PbCl2) salts [17].
  • An acute intoxication by lead chloride (conc. 2.5 - 10(-4)M) produces a temporary reduction of macromolecular syntheses in HeLa cells growing asynchronously [18].
  • Chronic exposure of the HN9 mouse hippocampal cell line to lead chloride (10(-14) M to 10(-6) M) for 96 hours resulted in a 50% increase in the levels of the particulate form of the protein with a parallel decrease in the soluble form (A beta PP) [19].

Associations of lead chloride with other chemical compounds


Gene context of lead chloride


Analytical, diagnostic and therapeutic context of lead chloride


  1. Directed shift of fatty acids from phospholipids to triacylglycerols in HL-60 cells induced by nanomolar concentrations of triethyl lead chloride: involvement of a pertussis toxin-sensitive pathway. Krug, H.F., Culig, H. Mol. Pharmacol. (1991) [Pubmed]
  2. Dose-dependent modulation of the in vitro cytokine production of human immune competent cells by lead salts. Hemdan, N.Y., Emmrich, F., Adham, K., Wichmann, G., Lehmann, I., El-Massry, A., Ghoneim, H., Lehmann, J., Sack, U. Toxicol. Sci. (2005) [Pubmed]
  3. Particle-induced X-ray emission (PIXE) for detection of lead in mouse blastocysts. Nilsson, B.O., Lindh, U., Sunde, T., Wide, M. Reprod. Toxicol. (1991) [Pubmed]
  4. Evaluation of effluent toxicity and ambient toxicity in a polluted lowland river. Bervoets, L., Baillieul, M., Blust, R., Verheyen, R. Environ. Pollut. (1996) [Pubmed]
  5. Influence of triethyl lead on neurofilaments in vivo and in vitro. Zimmermann, H.P., Plagens, U., Traub, P. Neurotoxicology (1987) [Pubmed]
  6. Changes in the organization of non-epithelial intermediate filaments induced by triethyl lead chloride. Zimmermann, H.P., Plagens, U., Vorgias, C.E., Traub, P. Exp. Cell Res. (1986) [Pubmed]
  7. Interaction of triethyl lead chloride with microtubules in vitro and in mammalian cells. Zimmermann, H.P., Doenges, K.H., Röderer, G. Exp. Cell Res. (1985) [Pubmed]
  8. Enhanced proinflammatory response to endotoxin after priming of macrophages with lead ions. Flohé, S.B., Brüggemann, J., Herder, C., Goebel, C., Kolb, H. J. Leukoc. Biol. (2002) [Pubmed]
  9. Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat. Deane, R., Bradbury, M.W. J. Neurochem. (1990) [Pubmed]
  10. Comparative effects of various lead salts on delayed hypersensitivity in mice. Descotes, J., Evreux, J.C., Laschi-Locquerie, A., Tachon, P. Journal of applied toxicology : JAT. (1984) [Pubmed]
  11. Low level lead exposure during lactation increases rough and tumble play fighting of juvenile rats. Holloway, W.R., Thor, D.H. Neurotoxicology and teratology. (1987) [Pubmed]
  12. The interaction of triethyl lead with tubulin and microtubules. Zimmermann, H.P., Faulstich, H., Hänsch, G.M., Doenges, K.H., Stournaras, C. Mutat. Res. (1988) [Pubmed]
  13. Effect of inorganic lead on the primordial germ cells in the mouse embryo. Wide, M., D'Argy, R. Teratology (1986) [Pubmed]
  14. Orally administered lead chloride induces bias of mucosal immunity. Goebel, C., Flohé, S.B., Kirchhoff, K., Herder, C., Kolb, H. Cytokine (2000) [Pubmed]
  15. Specificity of the effects of lead on brain energy metabolism for substrates donating a cytoplasmic reducing equivalent. Bull, R.J., Stanaszek, P.M., O'Neill, J.J., Lutkenhoff, S.D. Environ. Health Perspect. (1975) [Pubmed]
  16. Stimulation of arachidonic acid metabolism via phospholipase A2 by triethyl lead. Krug, H., Berndt, J. Eur. J. Biochem. (1987) [Pubmed]
  17. Heavy metals and the mammalian thymus: in vivo and in vitro investigations. Ficek, W. Toxicology and industrial health. (1994) [Pubmed]
  18. Reversible inhibition of DNA, RNA and protein synthesis in human cells by lead chloride. Skreb, Y., Habazin-Novak, V. Toxicology (1975) [Pubmed]
  19. The interaction between chronic low-level lead and the amyloid beta precursor protein. Davey, F.D., Breen, K.C. Amyloid (1998) [Pubmed]
  20. Effect of lead concentration on the level of glutathione, glutathione S-transferase, reductase and peroxidase in human blood. Hunaiti, A.A., Soud, M. Sci. Total Environ. (2000) [Pubmed]
  21. Lead toxicity via arachidonate signal transduction to growth responses in the splenic macrophage. Lee, J.J., Battles, A.H. Environmental research. (1994) [Pubmed]
  22. Effect of prenatal and neonatal exposure to lead on the affinity and number of estradiol receptors in the uterus. Wiebe, J.P., Barr, K.J. Journal of toxicology and environmental health. (1988) [Pubmed]
  23. Effect of triethyl lead on peristaltic contractile activity of the ileum of mice. Shraideh, Z. Cytobios (1999) [Pubmed]
  24. Effect on catfish (Clarias lazera) composition of ingestion rearing water contaminated with lead or aluminum compounds. Abdelhamid, A.M., el-Ayouty, S.A. Archiv für Tierernährung. (1991) [Pubmed]
  25. Cytodifferentiation of polar plant cells: use of anti-microtubular agents during the differentiation of statocytes from cress roots (Lepidium sativum L.). Hensel, W. Planta (1986) [Pubmed]
  26. Lead stimulates Golgi sialyltransferase at times coincident with the embryonic to adult conversion of the neural cell adhesion molecule (N-CAM). Breen, K.C., Regan, C.M. Toxicology (1988) [Pubmed]
  27. Effects of triethyl lead administration on the expression of glutathione S-transferase isoenzymes and quinone reductase in rat kidney and liver. Daggett, D.A., Nuwaysir, E.F., Nelson, S.A., Wright, L.S., Kornguth, S.E., Siegel, F.L. Toxicology (1997) [Pubmed]
  28. Effect of triethyl lead chloride on delta-aminolevulinic acid dehydratase. Bondy, S.C. Journal of toxicology and environmental health. (1986) [Pubmed]
  29. Inhibitory characteristics of lead chloride in sodium- and potassium- dependent adenosinetriphosphatase preparations derived from kidney, brain, and heart of several species. Nechay, B.R., Saunders, J.P. Journal of toxicology and environmental health. (1978) [Pubmed]
  30. A quantitative histological study of the effects of acute triethyl lead poisoning on the adult mouse brain. Sturrock, R.R. Neuropathol. Appl. Neurobiol. (1979) [Pubmed]
  31. Effects of triethyl lead on hot-plate responsiveness and biochemical properties of hippocampus. Bondy, S.C., Hong, J.S., Tilson, H.A., Walsh, T.J. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  32. Lead exposure on critical days of fetal life affects fertility in the female mouse. Wide, M. Teratology (1985) [Pubmed]
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