Disease relevance of Angiotensin II, ile(5)-

• Overexpression of the human angiotensin II type 1 receptor in the rat heart augments load induced cardiac hypertrophy [1].
• We report a strain of Mycoplasma hyorhinis isolated from opossum kidney cells with specific, high-affinity binding sites for human angiotensin II (Kd = 5.1 +/- 1.9 nM) [2].
• PURPOSE: To investigate the effect of the sarcosine analog of human angiotensin II ([sar]ATII) on the uptake and spatial distribution of immunotoxins (MW 210000 Da) in RD rhabdomyosarcoma xenografts in mice [3].

High impact information on Angiotensin II, ile(5)-

• MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts [4].
• Determination of peptide contact points in the human angiotensin II type I receptor (AT1) with photosensitive analogs of angiotensin II [5].
• Chinese hamster ovary cells expressing the cloned human angiotensin II receptor of the AT1 subtype (CHO-AT1 cells) were used as an 'in vitro" model system to investigate the action mechanism of the nonpeptide AT1 receptor blocker candesartan [6].
• In oocytes expressing only alpha1C,77 channels, application of human angiotensin II (1-10 microM) did not affect the amplitude or kinetics of Ba2+ currents (IBa) [7].
• Hence we have named it the human Angiotensin II Receptor-Associated Protein (AGTRAP) gene [8].

Biological context of Angiotensin II, ile(5)-

• Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization [9].
• We examined the intracellular signal transduction of two subtypes of human angiotensin II type 1 receptor (AT1aR and AT1bR) by means of the stable expression of each receptor cDNA in Chinese hamster ovary cells [10].
• The human angiotensin II (AII) type 1a receptor gene and its upstream control sequence has been cloned from a human leukocyte genomic library [11].
• Identification of regions in the human angiotensin II receptor type 1 responsible for Gi and Gq coupling by mutagenesis study [12].
• The gene of human angiotensin II type 2 (AT2) receptor was isolated from a genomic DNA library prepared from human placenta [13].

Anatomical context of Angiotensin II, ile(5)-

• The human angiotensin II type 1 (AT1) receptor gene was isolated and its promoter function analyzed by deletion mutant promoter/luciferase constructs in transfected Cos 7 cells [14].
• Translation of the human angiotensin II type 1 receptor mRNA is mediated by a highly efficient internal ribosome entry site [15].
• Studies investigating the mechanisms that govern the expression of the human angiotensin II type 1 receptor (hAT(1)R) gene have progressed slowly due to the lack of human cell lines that express the AT(1)R [16].
• The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library [17].
• Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues [18].

Associations of Angiotensin II, ile(5)- with other chemical compounds

• Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors [19].
• Adenovirus-mediated overexpression and stimulation of the human angiotensin II type 2 receptor in porcine cardiac fibroblasts does not modulate proliferation, collagen I mRNA expression and ERK1/ERK2 activity, but inhibits protein tyrosine phosphatases [20].
• This hypothesis was supported by the observation that sarcosine analogs of AII, which block AII-stimulated ACTH release in mammals, failed to block hAII-stimulated ACTH release in goldfish [21].
• Biological activities of asn1-,val5-angiotensin II (Hypertensin, Ciba, Asn1-,Val5-ANG II), ile5-angiotensin II (human angiotensin II, Ile5-ANG II) and sar1-angiotensin II (Sar1-ANG II) were compared in man [22].
• Atrial natriuretic peptide (alpha-hANP-99-126), 1 x 10(-8) to 5 x 10(-10) M was able to further relax the non-contracted aortic smooth muscle of rabbit after complete recovery from a previous challenge with human angiotensin II (AII), 1 x 10(-6) M [23].

Gene context of Angiotensin II, ile(5)-

• We analyzed cDNA and genomic clones encoding the human angiotensin II type-1 receptor, AT1 [24].
• Antibodies were produced against a synthetic peptide corresponding to amino acids (165-191) of the second extracellular loop of the human angiotensin II receptor subtype 1 (AT1) in rabbits [25].
• Polyclonal antibodies have been prepared against synthetic peptides of human angiotensin II type-1 (AT1) and type-2 (AT2) receptors [26].
• Effects of mutations in the highly conserved DRY motif on binding affinity, expression, and G-protein recruitment of the human angiotensin II type-2 receptor [27].
• Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens [28].

Analytical, diagnostic and therapeutic context of Angiotensin II, ile(5)-

• Human angiotensin II, chain B of bovine insulin, and porcine insulin were determined by time-of-flight secondary ion mass spectrometry under impact of approximately 25 keV Xe+ and SF5+ ion beams and approximately 100 MeV 252Cf fission fragments [29].
• Molecular cloning of the human angiotensin II type 2 receptor cDNA [30].

References