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Chemical Compound Review

Preussischblau     iron(+2) cation; iron(+3) cation;...

Synonyms: Turnbulls Blau, Berliner Blau, Parisian blue, Prussian blue, CHEBI:30069, ...
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Disease relevance of FERRIC FERROCYANIDE


Psychiatry related information on FERRIC FERROCYANIDE

  • In this post mortem study, we examined haem-rich deposits (HRDs) in patients with and without dementia, using a histochemical label (Prussian blue) to show haem, autofluorescence to detect red blood cells (RBCs), and immunohistochemistry for clotting-related factors and collagen IV [6].
  • Results obtained with Prussian Blue-modified electrodes showed a long operational lifetime, an excellent stability in a wide range of pH (3-9), a high sensitivity, and a fast response time [7].

High impact information on FERRIC FERROCYANIDE

  • Endothelin-1 immunoreactivity was most common in areas with a positive Prussian-blue reaction indicative of previous intraplaque haemorrhage [8].
  • These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactivity [9].
  • Light microscopic examination (Prussian blue staining) and EELS of FeCl3-preincubated explants demonstrated Fe3+ localization within devitalized GPBP connective tissue cells [10].
  • Iron demonstrable with the Prussian blue reaction at the osteoid/mineralized tissue interphase (osteoid seam) of trabecular bone was observed in only 2.3% of a total of 1536 conventionally fixed and processed, undecalcified, plastic-embedded biopsy specimens taken from the iliac crest of patients for various diagnostic purposes [11].
  • Findings, including results obtained in vitro, suggest that a positive Prussian blue reaction at the surface of trabecular bone signals the presence of low-molecular-weight ("free") iron, which can bind to the osteoid matrix directly, ie, without the help of osteoblasts [11].

Chemical compound and disease context of FERRIC FERROCYANIDE


Biological context of FERRIC FERROCYANIDE

  • Five leguminous and eight nonleguminous foods were analyzed for polyphenol concentration by the Prussian Blue and the Folin Denis methods and correlated with blood glucose response (glycemic index) in normal or diabetic volunteers [14].
  • The data indicate that the malignant cells in this patient are of early erythroid lineage at diagnosis and relapse and that classification of cell lineage can be enhanced by ultrastructural Prussian blue staining [15].
  • We confirmed transformation and expression by Northern blot analysis of the recombinant yeast, by Western blot analysis using an antibody against Escherichia coli-expressed TFH, and with Prussian blue staining that indicated that the yeast-expressed tadpole ferritin was assembled into a complex that could bind iron [16].
  • The hepatic iron deposit and oxidative stress induced-lipid peroxidation were estimated by Prussian blue staining and 3-nitrotyrosine staining, respectively [17].
  • SP enhancement of Prussian blue allows identification of reactive sites not readily visualized with AF or FeNTA-AF alone, and offers the potential for differentiating AF staining from other deposits or organelles of comparable density [18].

Anatomical context of FERRIC FERROCYANIDE

  • Our aim was to compare protoporphyrin concentrations, determined spectrophotometrically, with body iron stores, as assessed from the amount of iron demonstrable by Prussian blue staining of bone marrow aspirates [19].
  • Morphological studies by electron microscopy confirmed the existence of iron inside the lysosomes of macrophages of rejecting kidneys, while Prussian blue staining detected the presence of iron plaques in macrophages [20].
  • RESULTS: When ferumoxides-TA or MION-46L-TA was used, intracytoplasmic particles stained with Prussian blue stain were detected for all cell lines with a labeling efficiency of nearly 100% [21].
  • RESULTS: Intracytoplasmic nanoparticles were stained with Prussian blue when the ferumoxides-PLL complex had magnetically labeled the human mesenchymal stem and HeLa cells [22].
  • Finally, it is demonstrated that purely inorganic membranes of Prussian Blue (PB) and analogues can be prepared upon multiple sequential adsorption of transition metal cations and hexacyanoferrate anions [23].

Associations of FERRIC FERROCYANIDE with other chemical compounds



  • Hepatic iron deposition was determined in 32 HH patients following Perls Prussian blue staining (0-4+) [28].
  • In Part 2 of this work, the electronic and local structure of the photoinduced metastable magnetic state of the Prussian blue analogue Rb1.8Co4[Fe(CN)6]3.3-13H2O were characterized [29].
  • In addition, we evaluated myeloperoxidase staining as a marker of acute inflammation and potentially an increase in oxidant stress and Prussian blue and ferritin staining to assess iron status of the lung [30].
  • The areas of low signal intensity correlated well with alpha-actin and Prussian blue stain- and DiI-positive areas (P < .01), which indicates that MSCs specifically home to injured tissue [31].
  • MtF was specifically detected in MDS with ringed sideroblasts, and there was a close relationship between its expression and Prussian blue staining (r = 0.89, P < 0.001) [32].

Analytical, diagnostic and therapeutic context of FERRIC FERROCYANIDE


  1. Iron as a possible aggravating factor for osteopathy in itai-itai disease, a disease associated with chronic cadmium intoxication. Noda, M., Yasuda, M., Kitagawa, M. J. Bone Miner. Res. (1991) [Pubmed]
  2. Alveolar hemorrhage. Diagnostic criteria and results in 194 immunocompromised hosts. De Lassence, A., Fleury-Feith, J., Escudier, E., Beaune, J., Bernaudin, J.F., Cordonnier, C. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  3. Differentiation of hepatocellular carcinomas from hyperplastic nodules induced in rat liver with ferrite-enhanced MR imaging. Kawamori, Y., Matsui, O., Kadoya, M., Yoshikawa, J., Demachi, H., Takashima, T. Radiology. (1992) [Pubmed]
  4. Detection of Vascular Expression of E-selectin in Vivo with MR Imaging. Reynolds, P.R., Larkman, D.J., Haskard, D.O., Hajnal, J.V., Kennea, N.L., George, A.J., Edwards, A.D. Radiology. (2006) [Pubmed]
  5. Reduction of Prussian Blue by the two iron-reducing microorganisms Geobacter metallireducens and Shewanella alga. Jahn, M.K., Haderlein, S.B., Meckenstock, R.U. Environ. Microbiol. (2006) [Pubmed]
  6. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. Cullen, K.M., Kócsi, Z., Stone, J. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  7. Construction and analytical characterization of Prussian-Blue-based carbon paste electrodes and their assembly as oxidase enzyme sensors. Moscone, D., D'Ottavi, D., Compagnone, D., Palleschi, G., Amine, A. Anal. Chem. (2001) [Pubmed]
  8. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Zeiher, A.M., Ihling, C., Pistorius, K., Schächinger, V., Schaefer, H.E. Lancet (1994) [Pubmed]
  9. Morphologic and functional characteristics of bone marrow macrophages from imferon-treated mice. Fedorko, M.E. Blood (1975) [Pubmed]
  10. Inhibition of mineralization of glutaraldehyde-pretreated bovine pericardium by AlCl3. Mechanisms and comparisons with FeCl3, LaCl3, and Ga(NO3)3 in rat subdermal model studies. Webb, C.L., Schoen, F.J., Flowers, W.E., Alfrey, A.C., Horton, C., Levy, R.J. Am. J. Pathol. (1991) [Pubmed]
  11. Stainable bone iron in undecalcified, plastic-embedded sections. Occurrence in man related to the presence of "free" iron? Laeng, H., Egger, T., Roethlisberger, C., Cottier, H. Am. J. Pathol. (1988) [Pubmed]
  12. Ferrocyanide staining of transferrin and ferritin-conjugated antibody to transferrin. Parmley, R.T., Ostroy, F., Gams, R.A., DeLucas, L. J. Histochem. Cytochem. (1979) [Pubmed]
  13. Effects of Prussian blue and N-acetylcysteine on thallium toxicity in mice. Meggs, W.J., Cahill-Morasco, R., Shih, R.D., Goldfrank, L.R., Hoffman, R.S. J. Toxicol. Clin. Toxicol. (1997) [Pubmed]
  14. Relationship between polyphenol intake and blood glucose response of normal and diabetic individuals. Thompson, L.U., Yoon, J.H., Jenkins, D.J., Wolever, T.M., Jenkins, A.L. Am. J. Clin. Nutr. (1984) [Pubmed]
  15. Childhood undifferentiated leukemia with early erythroid markers and c-myb duplication. Castañeda, V.L., Parmley, R.T., Saldivar, V.A., Cheah, M.S. Leukemia (1991) [Pubmed]
  16. Enhanced iron uptake of Saccharomyces cerevisiae by heterologous expression of a tadpole ferritin gene. Shin, Y.M., Kwon, T.H., Kim, K.S., Chae, K.S., Kim, D.H., Kim, J.H., Yang, M.S. Appl. Environ. Microbiol. (2001) [Pubmed]
  17. Difference and similarity between non-alcoholic steatohepatitis and alcoholic liver disease. Kojima, H., Sakurai, S., Uemura, M., Takekawa, T., Morimoto, H., Tamagawa, Y., Fukui, H. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  18. Ultrastructural silver enhancement of Prussian blue-reactive iron in hematopoietic and intestinal cells. Parmley, R.T., Gilbert, C.S., White, D.A., Barton, J.C. J. Histochem. Cytochem. (1988) [Pubmed]
  19. Erythrocyte protoporphyrin in the detection of iron deficiency. McLaren, G.D., Carpenter, J.T., nino, H.V. Clin. Chem. (1975) [Pubmed]
  20. Magnetic resonance imaging detection of rat renal transplant rejection by monitoring macrophage infiltration. Zhang, Y., Dodd, S.J., Hendrich, K.S., Williams, M., Ho, C. Kidney Int. (2000) [Pubmed]
  21. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Frank, J.A., Miller, B.R., Arbab, A.S., Zywicke, H.A., Jordan, E.K., Lewis, B.K., Bryant, L.H., Bulte, J.W. Radiology. (2003) [Pubmed]
  22. Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Arbab, A.S., Bashaw, L.A., Miller, B.R., Jordan, E.K., Lewis, B.K., Kalish, H., Frank, J.A. Radiology. (2003) [Pubmed]
  23. Selective transport of ions and molecules across layer-by-layer assembled membranes of polyelectrolytes, p-sulfonato-calix[n]arenes and Prussian Blue-type complex salts. Tieke, B., Toutianoush, A., Jin, W. Advances in colloid and interface science. (2005) [Pubmed]
  24. X-ray illumination induced Fe(II) spin crossover in the Prussian blue analogue cesium iron hexacyanochromate. Papanikolaou, D., Margadonna, S., Kosaka, W., Ohkoshi, S., Brunelli, M., Prassides, K. J. Am. Chem. Soc. (2006) [Pubmed]
  25. Crystalline, mixed-valence manganese analogue of prussian blue: magnetic, spectroscopic, X-ray and neutron diffraction studies. Franz, P., Ambrus, C., Hauser, A., Chernyshov, D., Hostettler, M., Hauser, J., Keller, L., Krämer, K., Stoeckli-Evans, H., Pattison, P., Bürgi, H.B., Decurtins, S. J. Am. Chem. Soc. (2004) [Pubmed]
  26. Amperometric biosensor for glutamate using prussian blue-based "artificial peroxidase" as a transducer for hydrogen peroxide. Karyakin, A.A., Karyakina, E.E., Gorton, L. Anal. Chem. (2000) [Pubmed]
  27. Flow injection analysis of an ultratrace amount of arsenite using a Prussian blue-modified screen-printed electrode. Zen, J.M., Chen, P.Y., Kumar, A.S. Anal. Chem. (2003) [Pubmed]
  28. DMT1 genetic variability is not responsible for phenotype variability in hereditary hemochromatosis. Kelleher, T., Ryan, E., Barrett, S., O'Keane, C., Crowe, J. Blood Cells Mol. Dis. (2004) [Pubmed]
  29. Photoinduced ferrimagnetic systems in Prussian blue analogues C(I)xCo4[Fe(CN)6]y (C(I) = alkali cation). 4. Characterization of the ferrimagnetism of the photoinduced metastable state in Rb1.8Co4[Fe(CN)6]3.3-13H2O by K edges X-ray magnetic circular dichroism. Champion, G., Escax, V., Cartier Dit Moulin, C., Bleuzen, A., Villain, F., Baudelet, F., Dartyge, E., Verdaguer, M. J. Am. Chem. Soc. (2001) [Pubmed]
  30. Heme oxygenase-1 expression in human lungs with cystic fibrosis and cytoprotective effects against Pseudomonas aeruginosa in vitro. Zhou, H., Lu, F., Latham, C., Zander, D.S., Visner, G.A. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  31. MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy. Hauger, O., Frost, E.E., van Heeswijk, R., Deminière, C., Xue, R., Delmas, Y., Combe, C., Moonen, C.T., Grenier, N., Bulte, J.W. Radiology. (2006) [Pubmed]
  32. Flow cytometry evaluation of erythroid dysplasia in patients with myelodysplastic syndrome. Della Porta, M.G., Malcovati, L., Invernizzi, R., Travaglino, E., Pascutto, C., Maffioli, M., Gallì, A., Boggi, S., Pietra, D., Vanelli, L., Marseglia, C., Levi, S., Arosio, P., Lazzarino, M., Cazzola, M. Leukemia (2006) [Pubmed]
  33. Pituitary siderosis. A histologic, immunocytologic, and ultrastructural study. Bergeron, C., Kovacs, K. Am. J. Pathol. (1978) [Pubmed]
  34. Prussian blue based nanoelectrode arrays for H(2)O(2) detection. Karyakin, A.A., Puganova, E.A., Budashov, I.A., Kurochkin, I.N., Karyakina, E.E., Levchenko, V.A., Matveyenko, V.N., Varfolomeyev, S.D. Anal. Chem. (2004) [Pubmed]
  35. Synthesis, characterization and immobilization of Prussian blue nanoparticles. A potential tool for biosensing devices. Fiorito, P.A., Gonçales, V.R., Ponzio, E.A., de Torresi, S.I. Chem. Commun. (Camb.) (2005) [Pubmed]
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