Disease relevance of FERRIC FERROCYANIDE

• Renal calculi and calcified aortic walls were also stained with Prussian blue reagent in several patients [1].
• To establish the diagnosis of alveolar hemorrhage (AH) in cells recovered by bronchoalveolar lavage (BAL), Golde and colleagues created a score based on the hemosiderin content of alveolar macrophages stained with Prussian blue [2].
• Ferrite particles decreased the signal intensity of hyperplastic nodules but not that of hepatocellular carcinomas, and stainable iron was found in the former but not in the latter with Prussian blue iron stain [3].
• Flow cytometry, Perl Prussian blue staining for iron, and MR imaging were performed by using Chinese hamster ovary (CHO) cells expressing mouse E-selectin to detect binding of the conjugate in vitro, and a mouse model of contact hypersensitivity to oxazolone in the ear was used to investigate the in vivo characteristics of the MES-1-USPIO [4].
• Geobacter metallireducens could also reduce Prussian Blue coatings on sand, which was sampled from a contaminated site [5].

Psychiatry related information on FERRIC FERROCYANIDE

• In this post mortem study, we examined haem-rich deposits (HRDs) in patients with and without dementia, using a histochemical label (Prussian blue) to show haem, autofluorescence to detect red blood cells (RBCs), and immunohistochemistry for clotting-related factors and collagen IV [6].
• Results obtained with Prussian Blue-modified electrodes showed a long operational lifetime, an excellent stability in a wide range of pH (3-9), a high sensitivity, and a fast response time [7].

High impact information on FERRIC FERROCYANIDE

• Endothelin-1 immunoreactivity was most common in areas with a positive Prussian-blue reaction indicative of previous intraplaque haemorrhage [8].
• These macrophages on stained preparations are large, many times binucleate cells (up to 150 mu), and show Prussian blue reactivity [9].
• Light microscopic examination (Prussian blue staining) and EELS of FeCl3-preincubated explants demonstrated Fe3+ localization within devitalized GPBP connective tissue cells [10].
• Iron demonstrable with the Prussian blue reaction at the osteoid/mineralized tissue interphase (osteoid seam) of trabecular bone was observed in only 2.3% of a total of 1536 conventionally fixed and processed, undecalcified, plastic-embedded biopsy specimens taken from the iliac crest of patients for various diagnostic purposes [11].
• Findings, including results obtained in vitro, suggest that a positive Prussian blue reaction at the surface of trabecular bone signals the presence of low-molecular-weight ("free") iron, which can bind to the osteoid matrix directly, ie, without the help of osteoblasts [11].

Chemical compound and disease context of FERRIC FERROCYANIDE

• To evaluate the ultrastructural distribution of transferrin on the surface of L1210 ascites tumor cells, we used ferrocyanide to stain ferric iron (Prussian blue reaction) in transferrin, as well as in ferritin conjugated to antibody that was immunologically attached to the transferrin [12].
• Effects of Prussian blue and N-acetylcysteine on thallium toxicity in mice [13].

Biological context of FERRIC FERROCYANIDE

• Five leguminous and eight nonleguminous foods were analyzed for polyphenol concentration by the Prussian Blue and the Folin Denis methods and correlated with blood glucose response (glycemic index) in normal or diabetic volunteers [14].
• The data indicate that the malignant cells in this patient are of early erythroid lineage at diagnosis and relapse and that classification of cell lineage can be enhanced by ultrastructural Prussian blue staining [15].
• We confirmed transformation and expression by Northern blot analysis of the recombinant yeast, by Western blot analysis using an antibody against Escherichia coli-expressed TFH, and with Prussian blue staining that indicated that the yeast-expressed tadpole ferritin was assembled into a complex that could bind iron [16].
• The hepatic iron deposit and oxidative stress induced-lipid peroxidation were estimated by Prussian blue staining and 3-nitrotyrosine staining, respectively [17].
• SP enhancement of Prussian blue allows identification of reactive sites not readily visualized with AF or FeNTA-AF alone, and offers the potential for differentiating AF staining from other deposits or organelles of comparable density [18].

Anatomical context of FERRIC FERROCYANIDE

• Our aim was to compare protoporphyrin concentrations, determined spectrophotometrically, with body iron stores, as assessed from the amount of iron demonstrable by Prussian blue staining of bone marrow aspirates [19].
• Morphological studies by electron microscopy confirmed the existence of iron inside the lysosomes of macrophages of rejecting kidneys, while Prussian blue staining detected the presence of iron plaques in macrophages [20].
• RESULTS: When ferumoxides-TA or MION-46L-TA was used, intracytoplasmic particles stained with Prussian blue stain were detected for all cell lines with a labeling efficiency of nearly 100% [21].
• RESULTS: Intracytoplasmic nanoparticles were stained with Prussian blue when the ferumoxides-PLL complex had magnetically labeled the human mesenchymal stem and HeLa cells [22].
• Finally, it is demonstrated that purely inorganic membranes of Prussian Blue (PB) and analogues can be prepared upon multiple sequential adsorption of transition metal cations and hexacyanoferrate anions [23].

Associations of FERRIC FERROCYANIDE with other chemical compounds

• X-ray illumination induced Fe(II) spin crossover in the Prussian blue analogue cesium iron hexacyanochromate [24].
• Crystalline, mixed-valence manganese analogue of prussian blue: magnetic, spectroscopic, X-ray and neutron diffraction studies [25].
• Amperometric biosensor for glutamate using prussian blue-based "artificial peroxidase" as a transducer for hydrogen peroxide [26].
• In addition, the coupling of solid carbon paste modified with Prussian Blue and the enzymes glucose oxidase and choline oxidase led to the assembling of biosensors that showed an optimum working range at alkaline pH [7].
• Flow injection analysis of an ultratrace amount of arsenite using a Prussian blue-modified screen-printed electrode [27].

Gene context of FERRIC FERROCYANIDE

• Hepatic iron deposition was determined in 32 HH patients following Perls Prussian blue staining (0-4+) [28].
• In Part 2 of this work, the electronic and local structure of the photoinduced metastable magnetic state of the Prussian blue analogue Rb1.8Co4[Fe(CN)6]3.3-13H2O were characterized [29].
• In addition, we evaluated myeloperoxidase staining as a marker of acute inflammation and potentially an increase in oxidant stress and Prussian blue and ferritin staining to assess iron status of the lung [30].
• The areas of low signal intensity correlated well with alpha-actin and Prussian blue stain- and DiI-positive areas (P < .01), which indicates that MSCs specifically home to injured tissue [31].
• MtF was specifically detected in MDS with ringed sideroblasts, and there was a close relationship between its expression and Prussian blue staining (r = 0.89, P < 0.001) [32].

Analytical, diagnostic and therapeutic context of FERRIC FERROCYANIDE

• The immunoperoxidase technique combined with the prussian blue reaction revealed iron deposition in all five adenohypophysial cell types, indicating the iron uptake per se does not entirely block hormone storage [33].
• Photoinduced ferrimagnetic systems in Prussian blue analogues C(I)xCo4[Fe(CN)6]y (C(I) = alkali cation). 4. Characterization of the ferrimagnetism of the photoinduced metastable state in Rb1.8Co4[Fe(CN)6]3.3-13H2O by K edges X-ray magnetic circular dichroism [29].
• The specially deposited Prussian Blue denoted as "artificial peroxidase" was used as a transducer for hydrogen peroxide [26].
• We report on the possibility for nanostructuring of Prussian Blue by its electrochemical deposition through lyotropic liquid crystalline templates, which is noticed from atomic force microscopy images of the resulting surfaces [34].
• Synthesis, characterization and immobilization of Prussian blue nanoparticles. A potential tool for biosensing devices [35].

References