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Chemical Compound Review

neomycin     (2R,3S,4R,5R,6R)-5-amino-2- (aminomethyl)-6...

Synonyms: Actiline, Framygen, Actilin, Framycetin, Soframycin, ...
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Disease relevance of Framycetin


High impact information on Framycetin

  • Additionally, the spleens of the neo-free LTalpha KO mice displayed several features resembling those of LTbeta KO mice rather than conventional LTalpha KO animals [5].
  • We replaced the AP1/NFE2 sites with a neomycin resistance gene (neo) that is flanked by LoxP sites (floxed) [6].
  • These CHO cells were infected with a replication incompetent MoMuLV construct with a promoterless hygromycin phosphotransferase (hygro) gene inserted into the U3 region of the long terminal repeat and a second selectable marker, neomycin phosphotransferase (neo), expressed from an internal promoter [7].
  • Each HSV-TK(+) cell line was generated by stable transduction with a bicistronic retroviral vector containing the HSV-TK and neomycin resistance (neo) genes; each exhibited an IC50 for GCV of < or =4 microM [8].
  • To investigate the usefulness of keratinocytes as potential target cells for gene therapy, we used a retroviral vector (LASN) that contains both human adenosine deaminase (hADA) and neo genes [9].

Chemical compound and disease context of Framycetin


Biological context of Framycetin


Anatomical context of Framycetin


Associations of Framycetin with other chemical compounds


Gene context of Framycetin

  • Next, we removed the neo gene by Cre-mediated recombination, leaving a single LoxP site in place of the AP1/NFE2 sites [6].

Analytical, diagnostic and therapeutic context of Framycetin


  1. An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus. Wood, C.R., Morris, G.E., Alderman, E.M., Fouser, L., Kaufman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Severe anaphylactic reaction to topical administration of framycetin. Proebstle, T.M., Jugert, F.K., Merk, H.F., Gall, H. J. Allergy Clin. Immunol. (1995) [Pubmed]
  3. Laboratory evaluation of topically used antibiotics: framycetin MIC and extinction time data for Pseudomonas aeruginosa. Rawal, B.D. J. Antimicrob. Chemother. (1987) [Pubmed]
  4. Expression in Streptomyces ambofaciens of an Escherichia coli K-12 gene which confers resistance to hygromycin B. Kuhstoss, S., Rao, R.N. Gene (1983) [Pubmed]
  5. Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Liepinsh, D.J., Grivennikov, S.I., Klarmann, K.D., Lagarkova, M.A., Drutskaya, M.S., Lockett, S.J., Tessarollo, L., McAuliffe, M., Keller, J.R., Kuprash, D.V., Nedospasov, S.A. Mol. Cell. Biol. (2006) [Pubmed]
  6. Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Loyd, M.R., Okamoto, Y., Randall, M.S., Ney, P.A. Blood (2003) [Pubmed]
  7. Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. Integration into a discrete locus generates mutants expressing high levels of N-glycolylneuraminic acid. Hubbard, S.C., Walls, L., Ruley, H.E., Muchmore, E.A. J. Biol. Chem. (1994) [Pubmed]
  8. Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation. McMasters, R.A., Saylors, R.L., Jones, K.E., Hendrix, M.E., Moyer, M.P., Drake, R.R. Hum. Gene Ther. (1998) [Pubmed]
  9. L-histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential. Stockschlaeder, M.A., Storb, R., Osborne, W.R., Miller, A.D. Hum. Gene Ther. (1991) [Pubmed]
  10. Changing patterns of contact allergy in chronic inflammatory ear disease. Millard, T.P., Orton, D.I. Contact Derm. (2004) [Pubmed]
  11. A general practice study to compare the efficacy and tolerability of a spray ('Otomize') versus a standard drop formulation ('Sofradex') in the treatment of patients with otitis externa. Smith, R.B., Moodie, J. Current medical research and opinion. (1990) [Pubmed]
  12. A case of contact dermatitis due to methylprednisolone. Aramoto, Y., Uemura, T., Akiyoshi, E., Murata, Y., Kawashima, M. J. Dermatol. (1992) [Pubmed]
  13. Topical phenytoin in the treatment of split-thickness skin autograft donor sites: a comparative study with polyurethane membrane drape and conventional dressing. Yadav, J.K., Singhvi, A.M., Kumar, N., Garg, S. Burns : journal of the International Society for Burn Injuries. (1993) [Pubmed]
  14. A simple classification method for residual antibiotics using E. coli cells transformed by the calcium chloride method and drug resistance plasmid DNA. Lin, S.Y., Kondo, F. Microbios (2001) [Pubmed]
  15. Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination. Brisebois, J.J., DuBow, M.S. Mutat. Res. (1993) [Pubmed]
  16. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. Kumara Swamy, H.M., Krishna, V., Shankarmurthy, K., Abdul Rahiman, B., Mankani, K.L., Mahadevan, K.M., Harish, B.G., Raja Naika, H. Journal of ethnopharmacology (2007) [Pubmed]
  17. Determination of aminoglycosides in pharmaceutical formulations--II. High-performance liquid chromatography. Fabre, H., Sekkat, M., Blanchin, M.D., Mandrou, B. Journal of pharmaceutical and biomedical analysis. (1989) [Pubmed]
  18. NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice. Fu, X.W., Wang, D., Nurse, C.A., Dinauer, M.C., Cutz, E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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