The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Leucylleucine     2-[(2-amino-4-methyl- pentanoyl)amino]-4...

Synonyms: Leu-Leu, Leucyl-leucine, DL-Leu-DL-Leu, CHEMBL1221715, L3377_SIGMA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-DL-Leucyl-DL-leucine


High impact information on N-DL-Leucyl-DL-leucine


Biological context of N-DL-Leucyl-DL-leucine


Anatomical context of N-DL-Leucyl-DL-leucine


Associations of N-DL-Leucyl-DL-leucine with other chemical compounds


Gene context of N-DL-Leucyl-DL-leucine


Analytical, diagnostic and therapeutic context of N-DL-Leucyl-DL-leucine


  1. The role of major histocompatibility complex and non-major histocompatibility complex encoded antigens in generation of bile duct lesions during hepatic graft-vs.-host responses mediated by helper or cytotoxic T cells. Williams, F.H., Thiele, D.L. Hepatology (1994) [Pubmed]
  2. Lethal graft-vs-host disease induced by a class II MHC antigen only disparity is not mediated by cytotoxic T cells. Thiele, D.L., Bryde, S.E., Lipsky, P.E. J. Immunol. (1988) [Pubmed]
  3. The effect of leucyl-leucine methyl ester on proliferation and Ig secretion of EBV-transformed human B lymphocytes. Ohlin, M., Danielsson, L., Carlsson, R., Borrebaeck, C.A. Immunology (1989) [Pubmed]
  4. Aminopeptidase from Brevibacterium linens: activation and inhibition. Foissy, H. Zeitschrift für Lebensmittel-Untersuchung und -Forschung. (1978) [Pubmed]
  5. Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes. Thiele, D.L., Eigenbrodt, M.L., Bryde, S.E., Eigenbrodt, E.H., Lipsky, P.E. J. Clin. Invest. (1989) [Pubmed]
  6. Prevention of lethal murine graft versus host disease by treatment of donor cells with L-leucyl-L-leucine methyl ester. Charley, M., Thiele, D.L., Bennett, M., Lipsky, P.E. J. Clin. Invest. (1986) [Pubmed]
  7. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Thiele, D.L., Lipsky, P.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Isolation and characterization of human peripheral blood dendritic cells. Thomas, R., Davis, L.S., Lipsky, P.E. J. Immunol. (1993) [Pubmed]
  9. Lethal graft-vs-host disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells. Thiele, D.L., Charley, M.R., Calomeni, J.A., Lipsky, P.E. J. Immunol. (1987) [Pubmed]
  10. Leu-Leu-OMe sensitivity of human activated killer cells: delineation of a distinct class of cytotoxic T lymphocytes capable of lysing tumor targets. Thiele, D.L., Lipsky, P.E. J. Immunol. (1986) [Pubmed]
  11. Thy 1+ donor cells that promote allograft tolerance in sublethally irradiated MHC-disparate hosts. Pierce, G.E., Steers, J.L. Transplantation (1991) [Pubmed]
  12. Synthesis, photoreactivity and cytotoxic activity of caged compounds of L-leucyl-L-leucine methyl ester, an apoptosis inducer. Odaka, M., Furuta, T., Kobayashi, Y., Iwamura, M. Photochem. Photobiol. (1996) [Pubmed]
  13. In vitro immunization of murine lymphocytes using immobilized immunogens. Geeta, N.S., Ramanadham, M. Biotechnol. Appl. Biochem. (1996) [Pubmed]
  14. IL-10 augments antibody production in in vitro immunized lymphocytes by inducing a Th2-type response and B cell maturation. Xu, Q., Katakura, Y., Yamashita, M., Fang, S., Tamura, T., Matsumoto, S.E., Aiba, Y., Teruya, K., Osada, K., Nishikawa, R., Shirahata, S. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  15. Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens. Thiele, D.L., Calomeni, J.A., Lipsky, P.E. J. Immunol. (1987) [Pubmed]
  16. Effects of the immunosuppressive dipeptide L-leucyl-L-leucine O-methyl ester on epidermal Langerhans cells. Simon, J.C., Thiele, D.L., Schöpf, E., Sontheimer, R.D. J. Invest. Dermatol. (1992) [Pubmed]
  17. Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Thomas, J.M., Carver, F.M., Kasten-Jolly, J., Haisch, C.E., Rebellato, L.M., Gross, U., Vore, S.J., Thomas, F.T. Transplantation (1994) [Pubmed]
  18. A micro-electrode study of oligopeptide absorption by the small intestinal epithelium of Necturus maculosus. Boyd, C.A., Ward, M.R. J. Physiol. (Lond.) (1982) [Pubmed]
  19. Nitrogen absorption from isonitrogenous solutions of L-leucyl-L-leucine and L-leucine: a study in the isolated perfused rat small intestine. Plauth, M., Kremer, I., Raible, A., Stehle, P., Fürst, P., Hartmann, F. Clin. Sci. (1992) [Pubmed]
  20. Dipeptide metabolism in the isolated perfused rat small intestine. Plauth, M., Kremer, I., Raible, A., Stehle, P., Fürst, P., Hartmann, F. Clinical nutrition (Edinburgh, Scotland) (1991) [Pubmed]
  21. Uptake of a series of neutral dipeptides including L-alanyl-L-alanine, glycylglycine and glycylsarcosine by hamster jejunum in vitro. Matthews, D.M., Burston, D. Clin. Sci. (1984) [Pubmed]
  22. Induction of apoptosis of activated murine splenic T cells by cycloprodigiosin hydrochloride, a novel immunosuppressant. Azuma, T., Watanabe, N., Yagisawa, H., Hirata, H., Iwamura, M., Kobayashi, Y. Immunopharmacology (2000) [Pubmed]
  23. Modification of length, hydrophobic properties and electric charge of Bacillus subtilis alpha-amylase signal peptide and their different effects on the production of secretory proteins in B. subtilis and Escherichia coli cells. Nakamura, K., Fujita, Y., Itoh, Y., Yamane, K. Mol. Gen. Genet. (1989) [Pubmed]
  24. Ex vivo purging of allogeneic marrow with L-Leucyl-L-leucine methyl ester. A phase I study. Rosenfeld, C.S., Thiele, D.L., Shadduck, R.K., Zeigler, Z.R., Schindler, J. Transplantation (1995) [Pubmed]
  25. Characterization of the in vitro sensitivity of human lymphoid and hematopoietic progenitors to L-leucyl-L-leucine methyl ester. Pecora, A.L., Bordignon, C., Fumagalli, L., Radziejewski, C., Small, T.N., Pekle, K., O'Reilly, R.J., Keever, C.A. Transplantation (1991) [Pubmed]
  26. Simultaneous purification and properties of dehydropeptidase-I and aminopeptidase-M from rat kidney. Hirota, T., Nishikawa, Y., Takahagi, H., Igarashi, T., Kitagawa, H. Res. Commun. Chem. Pathol. Pharmacol. (1985) [Pubmed]
  27. On the specificity of human renin. Studies with peptide inhibitors. Poulsen, K., Haber, E., Burton, J. Biochim. Biophys. Acta (1976) [Pubmed]
  28. Treatment of donor cells with L-leucyl-L-leucine methyl ester prevents induction of graft-vs-host-like reaction in [lpr/lpr----+/+] chimera. Okuyama, H., Kobayashi, S., Harada, H., Kawaguchi, Y., Sekikawa, I. Clin. Immunol. Immunopathol. (1990) [Pubmed]
  29. Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes. Thiele, D.L., Lipsky, P.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  30. The role of leucyl-leucine methyl ester-sensitive cytotoxic cells in skin allograft rejection. Thiele, D.L., Geissler, G.H., Williams, F.H., Lipsky, P.E. Transplantation (1992) [Pubmed]
  31. L-leucyl-L-leucine methyl ester treatment of canine marrow and peripheral blood cells. Inhibition of proliferative responses with maintenance of the capacity for autologous marrow engraftment. Raff, R.F., Severns, E., Storb, R., Martin, P., Graham, T., Sandmaier, B., Schuening, F., Sale, G., Appelbaum, F.R. Transplantation (1988) [Pubmed]
  32. Epstein-Barr virus-induced transformation of human B lymphocytes: the effect of L-leucyl-L-leucine methyl ester on inhibitory T cell populations. Ohlin, M., Kristensson, K., Carlsson, R., Borrebaeck, C.A. Immunol. Lett. (1992) [Pubmed]
  33. Leucyl-leucine methyl ester-treated haploidentical donor lymphocyte infusions can mediate graft-versus-leukemia activity with minimal graft-versus-host disease risk. Hsieh, M.H., Varadi, G., Flomenberg, N., Korngold, R. Biol. Blood Marrow Transplant. (2002) [Pubmed]
WikiGenes - Universities