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Chemical Compound Review

AG-F-69564     2-aminopent-4-ynoic acid

Synonyms: AG-G-40537, P7888_SIGMA, ANW-43032, NSC-21940, AC1L3UMO, ...
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Disease relevance of PAG


High impact information on PAG

  • Injection of propargylglycine, an inhibitor of cystathionase, decreased MT induction by zinc in the tumor and diminished the resistance to these drugs [4].
  • Blockade of the transsulfuration pathway with propargylglycine suppressed clearance of M. smegmatis by macrophages and inhibited phagolysosomal fusion, whereas N-acetylcysteine promoted phagolysosomal fusion and enhanced mycobacterial clearance 3-fold compared with untreated cells [5].
  • Lowering endogenous H2S level with, D,L-propargylglycine and beta-cyano-L-alanine, two CSE inhibitors, significantly decreased [Ca2+]i, suggesting that endogenous H2S may have a positive tonic influence on [Ca2+]i homeostasis [6].
  • All the changes mentioned above also happen in the lactating mammary gland when propargylglycine, an inhibitor of the liver trans-sulphuration pathway, is administered [7].
  • A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors [8].

Chemical compound and disease context of PAG

  • Contents of cystathionine in the liver increased gradually from 0.25 mg to 30 mg/200 g body weight in proportion to the amounts of D,L-propargylglycine injected; in the kidney, 0.5 mg to 10 mg; in the brain, 5 mg to 20 mg; in the serum, 0.25 mg to 30 mg [9].

Biological context of PAG


Anatomical context of PAG


Associations of PAG with other chemical compounds


Gene context of PAG


Analytical, diagnostic and therapeutic context of PAG


  1. Hepatocyte-catalysed detoxification of cyanide by L- and D-cysteine. Huang, J., Niknahad, H., Khan, S., O'Brien, P.J. Biochem. Pharmacol. (1998) [Pubmed]
  2. A new metabolite of proglypargylglycine, gamma-glutamylpropargylglycylglycine, in liver of D,L-propargylglycine-administered rats. Ohta, J., Ubuka, T., Kodama, H., Sugahara, K., Nagamine, N. Biochim. Biophys. Acta (1997) [Pubmed]
  3. Inhibition effect of propargylglycine on human fibrosarcoma HT-1080 cell invasiveness. Haga, A., Nagase, H., Kito, H., Sato, T. Cancer Biochem. Biophys. (1998) [Pubmed]
  4. Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis. Satoh, M., Cherian, M.G., Imura, N., Shimizu, H. Cancer Res. (1994) [Pubmed]
  5. Monocyte Differentiation, Activation, and Mycobacterial Killing Are Linked to Transsulfuration-dependent Redox Metabolism. Garg, S., Vitvitsky, V., Gendelman, H.E., Banerjee, R. J. Biol. Chem. (2006) [Pubmed]
  6. Hydrogen sulphide regulates calcium homeostasis in microglial cells. Lee, S.W., Hu, Y.S., Hu, L.F., Lu, Q., Dawe, G.S., Moore, P.K., Wong, P.T., Bian, J.S. Glia (2006) [Pubmed]
  7. Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione. Zaragozá, R., García, C., Rus, A.D., Pallardó, F.V., Barber, T., Torres, L., Miralles, V.J., Viña, J.R. Biochem. J. (2003) [Pubmed]
  8. Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines. Natchus, M.G., Bookland, R.G., Laufersweiler, M.J., Pikul, S., Almstead, N.G., De, B., Janusz, M.J., Hsieh, L.C., Gu, F., Pokross, M.E., Patel, V.S., Garver, S.M., Peng, S.X., Branch, T.M., King, S.L., Baker, T.R., Foltz, D.J., Mieling, G.E. J. Med. Chem. (2001) [Pubmed]
  9. Effect of D,L-propargylglycine on cystathionine metabolism in rats. Awata, S., Nakayama, K., Kodama, H. Biochem. Int. (1984) [Pubmed]
  10. In vivo detoxification of cyanide by cystathionase gamma-lyase. Porter, D.W., Nealley, E.W., Baskin, S.I. Biochem. Pharmacol. (1996) [Pubmed]
  11. Inhibition of glutathione synthesis with propargylglycine enhances N-acetylmethionine protection and methylation in bromobenzene-treated Syrian hamsters. Lertratanangkoon, K., Scimeca, J.M., Wei, J.N. J. Nutr. (1999) [Pubmed]
  12. Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. Barber, T., Triguero, A., Martínez-López, I., Torres, L., García, C., Miralles, V.J., Viña, J.R. J. Nutr. (1999) [Pubmed]
  13. Modulation of endogenous production of H2S in rat tissues. Zhao, W., Ndisang, J.F., Wang, R. Can. J. Physiol. Pharmacol. (2003) [Pubmed]
  14. Formation of gamma-glutamylpropargylglycylglycine from propargylglycine in human blood and erythrocytes. Nagamine, N., Ohta, J., Masuoka, N., Kodama, H., Ubuka, T. Acta Med. Okayama (1999) [Pubmed]
  15. Reverse transsulfuration and its relationship to thienamycin biosynthesis in Streptomyces cattleya. Williamson, J.M., Meyer, R., Inamine, E. Antimicrob. Agents Chemother. (1985) [Pubmed]
  16. Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study. Srilatha, B., Adaikan, P.G., Moore, P.K. Eur. J. Pharmacol. (2006) [Pubmed]
  17. Liver intracellular L-cysteine concentration is maintained after inhibition of the trans-sulfuration pathway by propargylglycine in rats. Triguero, A., Barber, T., García, C., Puertes, I.R., Sastre, J., Viña, J.R. Br. J. Nutr. (1997) [Pubmed]
  18. Determination of D,L-propargylglycine and N-acetylpropargylglycine in urine and several tissues of D,L-propargylglycine-treated rats using liquid chromatography-mass spectrometry. Zhang, J., Machida, Y., Sugahara, K., Kodama, H. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
  19. Aviglycine and propargylglycine inhibit conidial germination and mycelial growth of Fusarium oxysporumf. sp. luffae. Jin, J.K., Adams, D.O., Ko, Y., Yu, C.W., Lin, C.H. Mycopathologia (2004) [Pubmed]
  20. Experimental diabetes increases the formation of sulfane by transsulfuration and inactivation of tyrosine aminotransferase in cytosols from rat liver. Hargrove, J.L., Trotter, J.F., Ashline, H.C., Krishnamurti, P.V. Metab. Clin. Exp. (1989) [Pubmed]
  21. A yeast with unusual sulphur amino acid metabolism. Piotrowska, M., Paszewski, A. J. Gen. Microbiol. (1990) [Pubmed]
  22. Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine. Washtien, W., Abeles, R.H. Biochemistry (1977) [Pubmed]
  23. Metabolic changes in glutathione and metallothionein in newborn rat liver. Gallant, K.R., Cherian, M.G. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  24. Sensitivity to radiation treatment and changes in metallothionein synthesis in a transplanted murine tumor. Shibuya, K., Cherian, M.G., Satoh, M. Radiat. Res. (1997) [Pubmed]
  25. Effects of inhibition of cystathionase activity on glutathione and metallothionein levels in the adult rat. Houghton, C.B., Cherian, M.G. J. Biochem. Toxicol. (1991) [Pubmed]
  26. Interaction between hydrogen sulfide/cystathionine gamma-lyase and carbon monoxide/heme oxygenase pathways in aortic smooth muscle cells. Jin, H.F., Du, J.B., Li, X.H., Wang, Y.F., Liang, Y.F., Tang, C.S. Acta Pharmacol. Sin. (2006) [Pubmed]
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