Gene Review:
Cdk4 - cyclin-dependent kinase 4
Mus musculus
Synonyms:
CRK3, Cell division protein kinase 4, Crk3, Cyclin-dependent kinase 4, PSK-J3, ...
- Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. Soni, R., O'Reilly, T., Furet, P., Muller, L., Stephan, C., Zumstein-Mecker, S., Fretz, H., Fabbro, D., Chaudhuri, B. J. Natl. Cancer Inst. (2001)
- Genetic evidence for functional dependency of p18Ink4c on Cdk4. Pei, X.H., Bai, F., Tsutsui, T., Kiyokawa, H., Xiong, Y. Mol. Cell. Biol. (2004)
- Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Zhang, T., Nanney, L.B., Luongo, C., Lamps, L., Heppner, K.J., DuBois, R.N., Beauchamp, R.D. Cancer Res. (1997)
- Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Reddy, H.K., Mettus, R.V., Rane, S.G., Graña, X., Litvin, J., Reddy, E.P. Cancer Res. (2005)
- Cdk4 is indispensable for postnatal proliferation of the anterior pituitary. Jirawatnotai, S., Aziyu, A., Osmundson, E.C., Moons, D.S., Zou, X., Kineman, R.D., Kiyokawa, H. J. Biol. Chem. (2004)
- Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Malumbres, M., Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., Barbacid, M. Cell (2004)
- Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Rane, S.G., Dubus, P., Mettus, R.V., Galbreath, E.J., Boden, G., Reddy, E.P., Barbacid, M. Nat. Genet. (1999)
- Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo. Huang, Z.Y., Baldwin, R.L., Hedrick, N.M., Gutmann, D.H. Oncogene (2002)
- Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours. Vax, V.V., Bibi, R., Diaz-Cano, S., Gueorguiev, M., Kola, B., Borboli, N., Bressac-de Paillerets, B., Walker, G.J., Dedov, I.I., Grossman, A.B., Korbonits, M. J. Endocrinol. (2003)
- Human melanocyte senescence and melanoma susceptibility genes. Bennett, D.C. Oncogene (2003)
- Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu, C., Shan, L., Yu, M., Snyderwine, E.G. Cancer Res. (2003)
- The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. Kitagawa, M., Higashi, H., Jung, H.K., Suzuki-Takahashi, I., Ikeda, M., Tamai, K., Kato, J., Segawa, K., Yoshida, E., Nishimura, S., Taya, Y. EMBO J. (1996)
- Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. Muraoka, R.S., Lenferink, A.E., Simpson, J., Brantley, D.M., Roebuck, L.R., Yakes, F.M., Arteaga, C.L. J. Cell Biol. (2001)
- Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells. Saab, R., Bills, J.L., Miceli, A.P., Anderson, C.M., Khoury, J.D., Fry, D.W., Navid, F., Houghton, P.J., Skapek, S.X. Mol. Cancer Ther. (2006)
- c-Myc and cyclin D3 (CcnD3) genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation. Rhee, K., Bresnahan, W., Hirai, A., Hirai, M., Thompson, E.A. Cancer Res. (1995)
- Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Connell-Crowley, L., Harper, J.W., Goodrich, D.W. Mol. Biol. Cell (1997)
- Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice. Mettus, R.V., Rane, S.G. Oncogene (2003)
- Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. Nguyen, M.D., Boudreau, M., Kriz, J., Couillard-Després, S., Kaplan, D.R., Julien, J.P. J. Neurosci. (2003)
- Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Kato, J.Y., Matsuoka, M., Polyak, K., Massagué, J., Sherr, C.J. Cell (1994)
- Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Faast, R., White, J., Cartwright, P., Crocker, L., Sarcevic, B., Dalton, S. Oncogene (2004)
- A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (CDK4) and its phosphorylation by CDK-activating kinase. Diehl, J.A., Sherr, C.J. Mol. Cell. Biol. (1997)
- Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation. Chen, B., Pollard, J.W. Mol. Endocrinol. (2003)
- Cdk4 activation is dependent on the subunit rearrangement in the complexes. Takahashi, H., Menjo, M., Kaneko, Y., Ikeda, K., Matsushime, H., Nakanishi, M. Biochem. Biophys. Res. Commun. (2000)
- Inhibition of retinoblastoma protein phosphorylation by myogenesis-induced changes in the subunit composition of the cyclin-dependent kinase 4 complex. Wang, J., Walsh, K. Cell Growth Differ. (1996)
- Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity. Tsutsui, T., Hesabi, B., Moons, D.S., Pandolfi, P.P., Hansel, K.S., Koff, A., Kiyokawa, H. Mol. Cell. Biol. (1999)
- Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rb-negative cells. González, T., Seoane, M., Caamaño, P., Viñuela, J., Domínguez, F., Zalvide, J. J. Biol. Chem. (2003)
- High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27(Kip) Cdk-complexes. Groth, A., Willumsen, B.M. Cell. Signal. (2005)
- Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. Shen, R., Wang, X., Drissi, H., Liu, F., O'Keefe, R.J., Chen, D. J. Biol. Chem. (2006)
- D-type cyclin-dependent kinase activity in mammalian cells. Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., Kato, J.Y. Mol. Cell. Biol. (1994)
- Glucocorticoid inhibition of fibroblast proliferation and regulation of the cyclin kinase inhibitor p21Cip1. Ramalingam, A., Hirai, A., Thompson, E.A. Mol. Endocrinol. (1997)
- Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Schulze, A., Zerfass, K., Spitkovsky, D., Henglein, B., Jansen-Dürr, P. Oncogene (1994)
- Regulation of cyclin-dependent kinase 4 during adipogenesis involves switching of cyclin D subunits and concurrent binding of p18INK4c and p27Kip1. Phelps, D.E., Xiong, Y. Cell Growth Differ. (1998)
- Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Zhang, T., Nanney, L.B., Peeler, M.O., Williams, C.S., Lamps, L., Heppner, K.J., DuBois, R.N., Beauchamp, R.D. Cancer Res. (1997)
- Immunohistochemical analysis of the D-type cyclin-dependent kinases Cdk4 and Cdk6, using a series of monoclonal antibodies. Lukas, C., Jensen, S.K., Bartkova, J., Lukas, J., Bartek, J. Hybridoma (1999)
- Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Fry, D.W., Harvey, P.J., Keller, P.R., Elliott, W.L., Meade, M., Trachet, E., Albassam, M., Zheng, X., Leopold, W.R., Pryer, N.K., Toogood, P.L. Mol. Cancer Ther. (2004)
- Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Martín, J., Hunt, S.L., Dubus, P., Sotillo, R., Néhmé-Pélluard, F., Magnuson, M.A., Parlow, A.F., Malumbres, M., Ortega, S., Barbacid, M. Oncogene (2003)