Gene Review:
CDKN2C - cyclin-dependent kinase inhibitor 2C (p18,...
Homo sapiens
Synonyms:
CDKN6, Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, INK4C, p18, ...
- Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. Iolascon, A., Giordani, L., Moretti, A., Basso, G., Borriello, A., Della Ragione, F. Hepatology (1998)
- Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Boström, J., Meyer-Puttlitz, B., Wolter, M., Blaschke, B., Weber, R.G., Lichter, P., Ichimura, K., Collins, V.P., Reifenberger, G. Am. J. Pathol. (2001)
- Screening of germline mutations in the CDK4, CDKN2C and TP53 genes in familial melanoma: a clinic-based population study. Platz, A., Hansson, J., Ringborg, U. Int. J. Cancer (1998)
- Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in childhood rhabdomyosarcoma. Iolascon, A., Faienza, M.F., Coppola, B., Rosolen, A., Basso, G., Della Ragione, F., Schettini, F. Genes Chromosomes Cancer (1996)
- Frequent inactivation of the cyclin-dependent kinase inhibitor p18 by homozygous deletion in multiple myeloma cell lines: ectopic p18 expression inhibits growth and induces apoptosis. Kulkarni, M.S., Daggett, J.L., Bender, T.P., Kuehl, W.M., Bergsagel, P.L., Williams, M.E. Leukemia (2002)
- The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Uziel, T., Zindy, F., Xie, S., Lee, Y., Forget, A., Magdaleno, S., Rehg, J.E., Calabrese, C., Solecki, D., Eberhart, C.G., Sherr, S.E., Plimmer, S., Clifford, S.C., Hatten, M.E., McKinnon, P.J., Gilbertson, R.J., Curran, T., Sherr, C.J., Roussel, M.F. Genes Dev. (2005)
- Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Guan, K.L., Jenkins, C.W., Li, Y., Nichols, M.A., Wu, X., O'Keefe, C.L., Matera, A.G., Xiong, Y. Genes Dev. (1994)
- Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6. Morse, L., Chen, D., Franklin, D., Xiong, Y., Chen-Kiang, S. Immunity (1997)
- p18Ink4c, but Not p27Kip1, Collaborates with Men1 To Suppress Neuroendocrine Organ Tumors. Bai, F., Pei, X.H., Nishikawa, T., Smith, M.D., Xiong, Y. Mol. Cell. Biol. (2007)
- A p18 mutant defective in CDK6 binding in human breast cancer cells. Lapointe, J., Lachance, Y., Labrie, Y., Labrie, C. Cancer Res. (1996)
- Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines. Gemma, A., Takenoshita, S., Hagiwara, K., Okamoto, A., Spillare, E.A., McMemamin, M.G., Hussain, S.P., Forrester, K., Zariwala, M., Xiong, Y., Harris, C.C. Int. J. Cancer (1996)
- Homozygous deletions of the CDKN2C/p18INK4C gene on the short arm of chromosome 1 in anaplastic oligodendrogliomas. Pohl, U., Cairncross, J.G., Louis, D.N. Brain Pathol. (1999)
- Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors. Husemann, K., Wolter, M., Büschges, R., Boström, J., Sabel, M., Reifenberger, G. J. Neuropathol. Exp. Neurol. (1999)
- A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. Kumar, R., Smeds, J., Berggren, P., Straume, O., Rozell, B.L., Akslen, L.A., Hemminki, K. Int. J. Cancer (2001)
- Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity. Franklin, D.S., Godfrey, V.L., O'Brien, D.A., Deng, C., Xiong, Y. Mol. Cell. Biol. (2000)
- Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope. Simos, G., Maison, C., Georgatos, S.D. J. Biol. Chem. (1996)
- Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells. Ariyama, H., Qin, B., Baba, E., Tanaka, R., Mitsugi, K., Harada, M., Nakano, S. J. Cell. Biochem. (2006)
- Identification of lamin B and histones as 1,25-dihydroxyvitamin D3-regulated nuclear phosphoproteins in HL-60 cells. Martell, R.E., Strahler, J.R., Simpson, R.U. J. Biol. Chem. (1992)
- Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines. Zhou, J.N., Linder, S. Anticancer Res. (1996)
- Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1. Blais, A., Monté, D., Pouliot, F., Labrie, C. J. Biol. Chem. (2002)
- Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. Karlsson, J., ØRa, I., Pörn-Ares, I., Påhlman, S. Clin. Cancer Res. (2004)
- Lack of imprinting of three human cyclin-dependent kinase inhibitor genes. Cost, G.J., Thompson, J.S., Reichard, B.A., Lee, J.Y., Feinberg, A.P. Cancer Res. (1997)
- Tumor suppressor INK4: quantitative structure-function analyses of p18INK4C as an inhibitor of cyclin-dependent kinase 4. Li, J., Poi, M.J., Qin, D., Selby, T.L., Byeon, I.J., Tsai, M.D. Biochemistry (2000)
- Analysis of the novel cyclin-dependent kinase 4 and 6 inhibitor gene p18 in lymphoma and leukemia cell lines. Siebert, R., Willers, C.P., Fosså, A., Kloke, O., Nowrousian, M.R., Seeber, S., Opalka, B. Leuk. Res. (1996)
- Identification of novel genes with prognostic value in childhood leukemia using cDNA microarray and quantitative RT-PCR. Hattori, H., Matsuzaki, A., Suminoe, A., Koga, Y., Tashiro, K., Hara, T. Pediatric hematology and oncology. (2006)