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Gene Review

CDKN2B  -  cyclin-dependent kinase inhibitor 2B (p15,...

Homo sapiens

Synonyms: CDK4I, Cyclin-dependent kinase 4 inhibitor B, INK4B, MTS-2, MTS2, ...
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Disease relevance of CDKN2B

  • Taken together, these results suggest that intragenic mutations in CDKN2A and CDKN2B occur in esophageal cancer, but that they are infrequent events [1].
  • In conjunction with our previously published data, we have identified a total of eight nucleic acid substitutions among 60 esophageal carcinomas; here, we describe one new CDKN2B nonsense mutation and one new silent CDKN2B mutation that occurred somatically [1].
  • Messenger RNA (mRNA) analysis showed that CDKN2C is expressed in all hepatoblastoma samples studied, while both CDKN2A and CDKN2B genes are not transcribed in the cancer specimens as well as in the matched normal liver tissues [2].
  • The 500 C>G polymorphism, however, was in linkage disequilibrium with approximately 50 kb apart the C>A intronic polymorphism in the CDKN2B gene (determined in 44 melanomas and 90 controls; Fisher exact test, p<0.0001) [3].
  • Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines [4].

High impact information on CDKN2B


Chemical compound and disease context of CDKN2B


Biological context of CDKN2B


Anatomical context of CDKN2B


Associations of CDKN2B with chemical compounds

  • Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide [8].
  • Only G15 iron deficient rats had greater dopaminergic activity than controls as indicated by increased tyrosine hydroxylase levels, phosphorylated tyrosine hydroxylase levels, and cellular dopamine in prefrontal cortex and striatum at P15 [17].
  • Circulating testosterone levels peak in male ferrets on postnatal day P15, and mothers provide maximal anogenital stimulation (AGS) to males at this same age [18].
  • There were fewer glial cells per cross-section on day 15 and the cross-sectional areas of optic nerves were smaller on days G20, P15 and P90 in the ethanol exposed animals [19].
  • Dispersion of ABM/P-15 in sodium hyaluronate carrier (PPutty) improves the handling properties of the graft material [20].

Other interactions of CDKN2B


Analytical, diagnostic and therapeutic context of CDKN2B


  1. Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Suzuki, H., Zhou, X., Yin, J., Lei, J., Jiang, H.Y., Suzuki, Y., Chan, T., Hannon, G.J., Mergner, W.J., Abraham, J.M. Hum. Mol. Genet. (1995) [Pubmed]
  2. Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. Iolascon, A., Giordani, L., Moretti, A., Basso, G., Borriello, A., Della Ragione, F. Hepatology (1998) [Pubmed]
  3. A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare. Kumar, R., Smeds, J., Berggren, P., Straume, O., Rozell, B.L., Akslen, L.A., Hemminki, K. Int. J. Cancer (2001) [Pubmed]
  4. Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines. Zhou, X., Suzuki, H., Shimada, Y., Imamura, M., Yin, J., Jiang, H.Y., Tarmin, L., Abraham, J.M., Meltzer, S.J. Genes Chromosomes Cancer (1995) [Pubmed]
  5. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15. Iavarone, A., Massagué, J. Nature (1997) [Pubmed]
  6. Alterations of INK4A and INK4B genes in adult soft tissue sarcomas: effect on survival. Orlow, I., Drobnjak, M., Zhang, Z.F., Lewis, J., Woodruff, J.M., Brennan, M.F., Cordon-Cardo, C. J. Natl. Cancer Inst. (1999) [Pubmed]
  7. Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma. Platz, A., Hansson, J., Månsson-Brahme, E., Lagerlof, B., Linder, S., Lundqvist, E., Sevigny, P., Inganäs, M., Ringborg, U. J. Natl. Cancer Inst. (1997) [Pubmed]
  8. Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide. Au, W.Y., Fung, A.T., Ma, E.S., Chan, C.H., Wong, K.F., Chim, C.S., Liang, R.H., Kwong, Y.L. Br. J. Haematol. (2005) [Pubmed]
  9. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Daskalakis, M., Nguyen, T.T., Nguyen, C., Guldberg, P., Köhler, G., Wijermans, P., Jones, P.A., Lübbert, M. Blood (2002) [Pubmed]
  10. Fluoranthene-2,3- and -1,5-diones are novel products from the bacterial transformation of fluoranthene. Kazunga, C., Aitken, M.D., Gold, A., Sangaiah, R. Environ. Sci. Technol. (2001) [Pubmed]
  11. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. Wolter, M., Reifenberger, J., Blaschke, B., Ichimura, K., Schmidt, E.E., Collins, V.P., Reifenberger, G. J. Neuropathol. Exp. Neurol. (2001) [Pubmed]
  12. Association of CDKN2A(p16)/CDKN2B(p15) alterations and homozygous chromosome arm 9p deletions in human lung carcinoma. Hamada, K., Kohno, T., Kawanishi, M., Ohwada, S., Yokota, J. Genes Chromosomes Cancer (1998) [Pubmed]
  13. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Fuxe, J., Akusjärvi, G., Goike, H.M., Roos, G., Collins, V.P., Pettersson, R.F. Cell Growth Differ. (2000) [Pubmed]
  14. De novo methylation of tumour suppressor genes CDKN2A and CDKN2B is a rare finding in B-cell chronic lymphocytic leukaemia. Martel, V., Guerci, A., Humbert, J.C., Gregoire, M.J., Chery, M., Lederlin, P., Jonveaux, P. Br. J. Haematol. (1997) [Pubmed]
  15. Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. Laud, K., Marian, C., Avril, M.F., Barrois, M., Chompret, A., Goldstein, A.M., Tucker, M.A., Clark, P.A., Peters, G., Chaudru, V., Demenais, F., Spatz, A., Smith, M.W., Lenoir, G.M., Bressac-de Paillerets, B. J. Med. Genet. (2006) [Pubmed]
  16. Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia. Cayuela, J.M., Madani, A., Sanhes, L., Stern, M.H., Sigaux, F. Blood (1996) [Pubmed]
  17. Early iron deficiency alters sensorimotor development and brain monoamines in rats. Unger, E.L., Paul, T., Murray-Kolb, L.E., Felt, B., Jones, B.C., Beard, J.L. J. Nutr. (2007) [Pubmed]
  18. Maternal odours induce Fos in the main but not the accessory olfactory bulbs of neonatal male and female ferrets. Chang, Y.M., Kelliher, K.R., Baum, M.J. J. Neuroendocrinol. (2001) [Pubmed]
  19. Effects of combined pre- and postnatal ethanol exposure (three trimester equivalency) on glial cell development in rat optic nerve. Phillips, D.E., Krueger, S.K. Int. J. Dev. Neurosci. (1992) [Pubmed]
  20. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. Vastardis, S., Yukna, R.A., Mayer, E.T., Atkinson, B.L. J. Periodontol. (2005) [Pubmed]
  21. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma. Dreyling, M.H., Roulston, D., Bohlander, S.K., Vardiman, J., Olopade, O.I. Genes Chromosomes Cancer (1998) [Pubmed]
  22. Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia. Healy, J., B??langer, H., Beaulieu, P., Larivi??re, M., Labuda, D., Sinnett, D. Blood (2007) [Pubmed]
  23. Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21. Beatty, B.G., Qi, S., Pienkowska, M., Herbrick, J.A., Scheidl, T., Zhang, Z.M., Kola, I., Scherer, S.W., Seth, A. Genomics (1999) [Pubmed]
  24. The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951. Mirebeau, D., Acquaviva, C., Suciu, S., Bertin, R., Dastugue, N., Robert, A., Boutard, P., Méchinaud, F., Plouvier, E., Otten, J., Vilmer, E., Cavé, H. Haematologica (2006) [Pubmed]
  25. Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours. Schmidt, E.E., Ichimura, K., Messerle, K.R., Goike, H.M., Collins, V.P. Br. J. Cancer (1997) [Pubmed]
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