Disease relevance of Hrt1

• Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease [1].
• For each case subject, five sex- and age-matched control subjects were selected from the National Heart, Lung, and Blood Institute Family Heart Study or the Framingham Offspring Study. RESULTS: Among case subjects, neither disease duration, nor dystonia, nor chorea score was significantly associated with BMI [2].
• RESULTS: Heart xenografts in both untreated and mAb-treated BALB/c recipients were rejected at 6.0+/-0.7 days and 8.5+/-1.3 days, respectively, with typical features of AVR, characterized by hemorrhage, fibrin deposition, thrombosis, and massive accumulations of anti-rat IgG and IgM [3].
• RESULTS: Heart/body weight ratio after ligation was increased by approximately 10% over sham control although there is no statistically significant difference in hemodynamic parameters between the two groups [4].
• TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study [5].

Psychiatry related information on Hrt1

• To expedite their development, we have established the Center for New Mouse Models of Heart, Lung, Blood, and Sleep Disorders at The Jackson Laboratory. We are using a phenotype-driven approach to identify mutations leading to atherosclerosis, hypertension, obesity, blood disorders, lung dysfunction, thrombosis, and disordered sleep [6].

High impact information on Hrt1

• An alpha1-adrenergic receptor (alpha1-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result was due to alpha1-AR inhibition or a nonspecific drug effect [7].
• Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study [8].
• METHODS AND RESULTS: Heart failure was induced in female mice by intraperitoneal injection of doxorubicin (2 mg/kg twice per week over 2 cycles of 2 weeks separated by a 2-week drug-free period) [9].
• Topoisomerase Inhibition Accelerates Gene Expression after Adeno-associated Virus-mediated Gene Transfer to the Mammalian Heart [10].
• AIMS: Heart transplantation of adipose tissue-derived stromal cells (ADSCs) is under evaluation as a therapy for cardiac repair [11].

Chemical compound and disease context of Hrt1

• The American Heart Association recommends increasing intakes of n-3 polyunsaturated fatty acids (PUFA) to reduce the risk of vascular disease in high-risk individuals; however, the long-term effects of these bioactive fatty acids on glucose metabolism in insulin resistance are controversial [12].

Biological context of Hrt1

• BACKGROUND: Heart transplantation causes complex changes in the biological homeostasis of the graft [13].
• RESULTS: Heart rate, blood pressures, left ventricular (LV) dimensions, fractional shortening and maximal and minimal dP/dt did not differ significantly between the three genotypes of either gender at any age [14].
• 5. Heart rate, peak blood flow velocities, and velocity time integrals in all vessels increased from E9.5-14.5, indicating increasing stroke volume and cardiac output [15].
• A heartbeat was first detected at 5 S, and blood vascular flow at 7 S. Heart rate, peak arterial velocity, and velocity-time integral showed progressive increases that indicated a dramatically increasing cardiac output from even the earliest stages [16].
• 1. Heart rates and oxygen consumption were measured for normothermic, hibernating, and arousing Zapus princeps [17].

Anatomical context of Hrt1

• This effect is apparent at the single myocyte level and depends on sarcoplasmic reticulum (SR) Ca transport and Ca/calmodulin dependent protein kinase [CaMKII; see R. A. Bassani, A. Mattiazzi, and D. M. Bers. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H703-H712, 1995] [18].

Associations of Hrt1 with chemical compounds

• 5. Heart triacylglycerols were higher in mice than rats in the fed state and increased still further during a fast of 48 hr during which time little change was observed in the rat [19].
• In anaesthetized cats dp/dtmax was augmented by maximally 141-216% at 0.1-10 mg/kg i.v. Heart rate rose after AR-L 57 BS and AR-L 115 BS by 17-38% and decreased after AR-L 100 BS by 17% [20].
• BACKGROUND: Heart failure is associated with deranged cardiac energy metabolism, including reductions of creatine and phosphocreatine [21].
• The Lipopolysaccharide-Induced Up-Regulation of Bradykinin B(2)-Receptor in the Mouse Heart Is Mediated by Tumor Necrosis Factor-alpha and Angiotensin II [22].

Other interactions of Hrt1

• The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging. Journal of Molecular and Cellular Cardiology (2001) 33, 1031-1040 [23].
• National Heart, Lung, and Blood Institute (NHLBI) workshop on the importance of minor histocompatibility antigens in marrow transplantation. September 16-17, 1996; Bethesda, Maryland [24].
• We have utilized this system in an attempt to overcome the perinatal lethality resulting from constitutive transgenic expression in the heart (Valencik & McDonald, Am J Physiol Heart Circ Physiol 280: H361-H367) [25].
• Thus we reported the follow-up of 18-patients with Chagas' heart disease submitted to orthotopic heart transplants from 1985 to 1993 at The Heart Institute. The patients were in functional class IV or II, with sustained ventricular tachycardia episodes [26].
• METHODS: Heart and lung functions were evaluated respectively by means of isolated heart preparation, bronchoalveolar lavage fluid protein concentration, lung wet/dry weight ratio, lung homogenate myeloperoxidase activity, and histopathologic grading [27].

Analytical, diagnostic and therapeutic context of Hrt1

• RESUKTS: Heart rate and coronary resistance were similar in both groups during baseline and reperfusion periods [28].
• RESULTS: Heart allograft survival was only significantly prolonged in the BALB/c SC + FK506 pre-fed mice [29].
• Immunohistochemistry and Q-PCR performed on endomyocardial biopsies after heart transplantation showing no rejection (n=10) or grade IB (n=10) or IIIA (n=10) rejection, according to International Society of Heart and Lung Transplantation criteria, confirmed the results obtained from the murine model [30].

References