Gene Review:
AICDA - activation-induced cytidine deaminase
Homo sapiens
Synonyms:
AID, ARP2, Activation-induced cytidine deaminase, CDA2, Cytidine aminohydrolase, ...
- Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations. Epeldegui, M., Hung, Y.P., McQuay, A., Ambinder, R.F., Mart??nez-Maza, O. Mol. Immunol. (2007)
- Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas. Greeve, J., Philipsen, A., Krause, K., Klapper, W., Heidorn, K., Castle, B.E., Janda, J., Marcu, K.B., Parwaresch, R. Blood (2003)
- Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone. Albesiano, E., Messmer, B.T., Damle, R.N., Allen, S.L., Rai, K.R., Chiorazzi, N. Blood (2003)
- Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL. Hardianti, M.S., Tatsumi, E., Syampurnawati, M., Furuta, K., Saigo, K., Nakamachi, Y., Kumagai, S., Ohno, H., Tanabe, S., Uchida, M., Yasuda, N. Leukemia (2004)
- Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21). Hardianti, M.S., Tatsumi, E., Syampurnawati, M., Furuta, K., Suzuki, A., Saigo, K., Kawano, S., Takenokuchi, M., Kumagai, S., Matsuo, Y., Koizumi, T., Takeuchi, M. Eur. J. Haematol. (2005)
- Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Papavasiliou, F.N., Schatz, D.G. Cell (2002)
- Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Labelouse, R., Gennery, A., Tezcan, I., Ersoy, F., Kayserili, H., Ugazio, A.G., Brousse, N., Muramatsu, M., Notarangelo, L.D., Kinoshita, K., Honjo, T., Fischer, A., Durandy, A. Cell (2000)
- Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Krause, M., Dent, E.W., Bear, J.E., Loureiro, J.J., Gertler, F.B. Annu. Rev. Cell Dev. Biol. (2003)
- Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas. Martin, A., Bardwell, P.D., Woo, C.J., Fan, M., Shulman, M.J., Scharff, M.D. Nature (2002)
- AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Petersen-Mahrt, S.K., Harris, R.S., Neuberger, M.S. Nature (2002)
- Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Wong, K.W., Isberg, R.R. Curr. Opin. Microbiol. (2005)
- Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels. Noguchi, E., Shibasaki, M., Inudou, M., Kamioka, M., Yokouchi, Y., Yamakawa-Kobayashi, K., Hamaguchi, H., Matsui, A., Arinami, T. J. Allergy Clin. Immunol. (2001)
- Linkage and association of childhood asthma with the chromosome 12 genes. Shao, C., Suzuki, Y., Kamada, F., Kanno, K., Tamari, M., Hasegawa, K., Aoki, Y., Kure, S., Yang, X., Endo, H., Takayanagi, R., Nakazawa, C., Morikawa, T., Morikawa, M., Miyabayashi, S., Chiba, Y., Karahashi, M., Saito, S., Tamura, G., Shirakawa, T., Matsubara, Y. J. Hum. Genet. (2004)
- Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. Lee, C.H., Melchers, M., Wang, H., Torrey, T.A., Slota, R., Qi, C.F., Kim, J.Y., Lugar, P., Kong, H.J., Farrington, L., van der Zouwen, B., Zhou, J.X., Lougaris, V., Lipsky, P.E., Grammer, A.C., Morse, H.C. J. Exp. Med. (2006)
- Somatic hypermutation of the AID transgene in B and non-B cells. Martin, A., Scharff, M.D. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Cytidine deaminase: a new genetic polymorphism demonstrated in human granulocytes. Teng, Y.S., Anderson, J.E., Giblett, E.R. Am. J. Hum. Genet. (1975)
- Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. Takhar, P., Smurthwaite, L., Coker, H.A., Fear, D.J., Banfield, G.K., Carr, V.A., Durham, S.R., Gould, H.J. J. Immunol. (2005)
- Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers. Bergqvist, P., G??rdby, E., Stensson, A., Bemark, M., Lycke, N.Y. J. Immunol. (2006)
- C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Barreto, V., Reina-San-Martin, B., Ramiro, A.R., McBride, K.M., Nussenzweig, M.C. Mol. Cell (2003)
- Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase. Martomo, S.A., Fu, D., Yang, W.W., Joshi, N.S., Gearhart, P.J. J. Immunol. (2005)
- Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. Morgan, H.D., Dean, W., Coker, H.A., Reik, W., Petersen-Mahrt, S.K. J. Biol. Chem. (2004)
- Talin: an emerging focal point of adhesion dynamics. Nayal, A., Webb, D.J., Horwitz, A.F. Curr. Opin. Cell Biol. (2004)
- Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. Ronai, D., Iglesias-Ussel, M.D., Fan, M., Li, Z., Martin, A., Scharff, M.D. J. Exp. Med. (2007)
- Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells. Machida, K., Cheng, K.T., Pavio, N., Sung, V.M., Lai, M.M. J. Virol. (2005)
- Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells. Zheng, H., Li, M., Ren, W., Zeng, L., Liu, H.D., Hu, D., Deng, X., Tang, M., Shi, Y., Gong, J., Cao, Y. Mol. Immunol. (2007)
- Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Dedeoglu, F., Horwitz, B., Chaudhuri, J., Alt, F.W., Geha, R.S. Int. Immunol. (2004)
- Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma. Cui, T., Wang, L., Wu, J., Hu, L., Xie, J. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2003)
- Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. Lenz, G., Nagel, I., Siebert, R., Roschke, A.V., Sanger, W., Wright, G.W., Dave, S.S., Tan, B., Zhao, H., Rosenwald, A., Muller-Hermelink, H.K., Gascoyne, R.D., Campo, E., Jaffe, E.S., Smeland, E.B., Fisher, R.I., Kuehl, W.M., Chan, W.C., Staudt, L.M. J. Exp. Med. (2007)
- Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID. Dijkman, R., Tensen, C.P., Buettner, M., Niedobitek, G., Willemze, R., Vermeer, M.H. Blood (2006)
- The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains. Jung, G., Remmert, K., Wu, X., Volosky, J.M., Hammer, J.A. J. Cell Biol. (2001)
- Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry. Kiselar, J.G., Mahaffy, R., Pollard, T.D., Almo, S.C., Chance, M.R. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Absence of immunoglobulin class switch in primary lymphomas of the central nervous system. Montesinos-Rongen, M., Schmitz, R., Courts, C., Stenzel, W., Bechtel, D., Niedobitek, G., Blümcke, I., Reifenberger, G., von Deimling, A., Jungnickel, B., Wiestler, O.D., Küppers, R., Deckert, M. Am. J. Pathol. (2005)