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Gene Review

Alb  -  albumin

Mus musculus

Synonyms: Alb-1, Alb1, Serum albumin
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Disease relevance of Alb1


High impact information on Alb1

  • Homozygosity of Alb-uPA was associated with significantly higher levels of human hepatocyte engraftment, and these mice developed prolonged HCV infections with high viral titers after inoculation with infected human serum [6].
  • The albumin (Alb) promoter provides constitutive, high levels of transgenes in live [7].
  • Analysis of revertants of the Alb1 mutant revealed that one of the two mutations is critical for the temperature-sensitive phenotype; the second mutation is phenotypically silent [2].
  • Proteinuria was reduced in estradiol-treated Alb/TGF-beta mice compared to placebo-treated transgenic mice [8].
  • Both the mammary tumor burden and the incidence of lung metastases were lower in the Alb-TIMP-1/MMTV-MT mice than their MMTV-MT littermates [9].

Biological context of Alb1

  • The methods of somatic cell genetics and molecular hybridization were applied to a panel of mouse X rat hepatocyte hybrids segregating rat chromosomes to assign the rat genes coding for two serum proteins, albumin and alpha-fetoprotein (Alb and Afp) [10].
  • These results demonstrate that the mouse Trf and Alb enhancer/promoters are active in sheep and suggest that alternate strategies for expressing growth-related genes may be required to modulate growth in sheep [11].
  • Their genotypes were [C/C, h/h, GcB/GcB, Alb/Alb], [C/C, hi/hi, GcA/GcA, alb/alb] and [C/C, h/h, GcA/GcA, alb/alb], respectively [12].
  • Five transgenic lines were developed, all of which expressed the Alb/TGF-beta 1 transgene selectively in hepatocytes [13].
  • Analysis of the Alb-TIMP-1/MMTV-MT tumors showed evidence of decreased proliferative activity and inhibition of apoptosis, whereas microvascular density was not affected [9].

Anatomical context of Alb1


Associations of Alb1 with chemical compounds


Regulatory relationships of Alb1

  • The molecular hybridization of DNAs from different hybrids with cloned DNA probes showed that all the hybrid clones possessing the rat Alb gene and expressing it also retained the rat Afp locus, which is not expressed in these hybrids [10].

Other interactions of Alb1

  • The implications of this finding in relation to the function and evolution of AFP and Alb are discussed [18].
  • Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response [19].
  • In a previous study, the s locus was included in the same linkage group as serum albumin (Alb) and vitamin-D binding protein (GC) which are mapped on chicken (Gallus gallus) chromosome 4 (GGA4) [20].
  • The tripeptidase locus, Pep-2, also may be loosely linked to Alb in this group [21].

Analytical, diagnostic and therapeutic context of Alb1


  1. Generation and chracterization of variants of mouse hepatoma cells with defects in hepato-specific gene expression. I. Albumin synthesis variants. Darlington, G.J., Papaconstantinou, J., Sammons, D.W., Brown, P.C., Wong, E.Y., Esterman, A.L., Kang, J. Somatic Cell Genet. (1982) [Pubmed]
  2. Optimization of targeted RNA recombination and mapping of a novel nucleocapsid gene mutation in the coronavirus mouse hepatitis virus. Masters, P.S., Koetzner, C.A., Kerr, C.A., Heo, Y. J. Virol. (1994) [Pubmed]
  3. Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice. Barone, M., Maiorano, E., Ladisa, R., Cuomo, R., Pece, A., Berloco, P., Caruso, M.L., Valentini, A.M., Iolascon, A., Francavilla, A., Di Leo, A., Ierardi, E. Hepatology (2003) [Pubmed]
  4. Gamma Interferon Loaded onto Albumin Nanoparticles: In Vitro and In Vivo Activities against Brucella abortus. Segura, S., Gamazo, C., Irache, J.M., Espuelas, S. Antimicrob. Agents Chemother. (2007) [Pubmed]
  5. Reduced hematopoietic function and enhanced radiosensitivity of transforming growth factor-beta1 transgenic mice. Vodovotz, Y., Lucia, M.S., DeLucca, A.M., Mitchell, J.B., Kopp, J.B. Int. J. Cancer (2000) [Pubmed]
  6. Hepatitis C virus replication in mice with chimeric human livers. Mercer, D.F., Schiller, D.E., Elliott, J.F., Douglas, D.N., Hao, C., Rinfret, A., Addison, W.R., Fischer, K.P., Churchill, T.A., Lakey, J.R., Tyrrell, D.L., Kneteman, N.M. Nat. Med. (2001) [Pubmed]
  7. Transgenic expression of hepatitis C virus structural proteins in the mouse. Kawamura, T., Furusaka, A., Koziel, M.J., Chung, R.T., Wang, T.C., Schmidt, E.V., Liang, T.J. Hepatology (1997) [Pubmed]
  8. Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. Blush, J., Lei, J., Ju, W., Silbiger, S., Pullman, J., Neugarten, J. Kidney Int. (2004) [Pubmed]
  9. Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice. Yamazaki, M., Akahane, T., Buck, T., Yoshiji, H., Gomez, D.E., Schoeffner, D.J., Okajima, E., Harris, S.R., Bunce, O.R., Thorgeirsson, S.S., Thorgeirsson, U.P. Carcinogenesis (2004) [Pubmed]
  10. Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and alpha-fetoprotein genes and assignment to chromosome 14. Szpirer, J., Levan, G., Thörn, M., Szpirer, C. Cytogenet. Cell Genet. (1984) [Pubmed]
  11. Transferrin- and albumin-directed expression of growth-related peptides in transgenic sheep. Rexroad, C.E., Mayo, K., Bolt, D.J., Elsasser, T.H., Miller, K.F., Behringer, R.R., Palmiter, R.D., Brinster, R.L. J. Anim. Sci. (1991) [Pubmed]
  12. Mapping of the hooded, Gc protein, and albumin gene loci in linkage group VI of the laboratory rat. Shumiya, S., Nagase, S. Biochem. Genet. (1988) [Pubmed]
  13. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L., Roberts, A.B., Sporn, M.B., Thorgeirsson, S.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. The role of advanced glycation end products in retinal microvascular leukostasis. Moore, T.C., Moore, J.E., Kaji, Y., Frizzell, N., Usui, T., Poulaki, V., Campbell, I.L., Stitt, A.W., Gardiner, T.A., Archer, D.B., Adamis, A.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  15. Developmental fate of a human insulin gene in a transgenic mouse. van der Putten, H., Botteri, F., Illmensee, K. Mol. Gen. Genet. (1984) [Pubmed]
  16. Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice. Vodovotz, Y., Kopp, J.B., Takeguchi, H., Shrivastav, S., Coffin, D., Lucia, M.S., Mitchell, J.B., Webber, R., Letterio, J., Wink, D., Roberts, A.B. J. Leukoc. Biol. (1998) [Pubmed]
  17. S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma. Gandley, R.E., Tyurin, V.A., Huang, W., Arroyo, A., Daftary, A., Harger, G., Jiang, J., Pitt, B., Taylor, R.N., Hubel, C.A., Kagan, V.E. Hypertension (2005) [Pubmed]
  18. Short sequences of high homology between the primary structures of alpha-fetoprotein and albumin. Moro, R., Villacampa, M.J. Tumour Biol. (1986) [Pubmed]
  19. Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response. Walters, K.A., Joyce, M.A., Thompson, J.C., Smith, M.W., Yeh, M.M., Proll, S., Zhu, L.F., Gao, T.J., Kneteman, N.M., Tyrrell, D.L., Katze, M.G. PLoS Pathog. (2006) [Pubmed]
  20. Mapping of panda plumage color locus on the microsatellite linkage map of the Japanese quail. Miwa, M., Inoue-Murayama, M., Kobayashi, N., Kayang, B.B., Mizutani, M., Takahashi, H., Ito, S. BMC Genet. (2006) [Pubmed]
  21. Linkage relationships among eleven biochemical loci in Peromyscus. Dawson, W.D., Huang, L.L., Felder, M.R., Shaffer, J.B. Biochem. Genet. (1983) [Pubmed]
  22. Human yolk sac tumor serially transplanted in nude mice: its morphologic and functional properties. Hata, J.I., Ueyama, Y., Tamaoki, N., Akatsuka, A., Yoshimura, S., Shimuzu, K., Morikawa, Y., Furukawa, T. Cancer (1980) [Pubmed]
  23. Targeting of transferrin receptors in nude mice bearing A431 and LS174T xenografts with [18F]holo-transferrin: permeability and receptor dependence. Aloj, L., Jogoda, E., Lang, L., Caracò, C., Neumann, R.D., Sung, C., Eckelman, W.C. J. Nucl. Med. (1999) [Pubmed]
  24. Active nuclear import of single-stranded oligonucleotides and their complexes with non-karyophilic macromolecules. Hartig, R., Shoeman, R.L., Janetzko, A., Grüb, S., Traub, P. Biol. Cell (1998) [Pubmed]
  25. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Lindner, J.R., Coggins, M.P., Kaul, S., Klibanov, A.L., Brandenburger, G.H., Ley, K. Circulation (2000) [Pubmed]
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