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Gene Review

Ccl4  -  chemokine (C-C motif) ligand 4

Rattus norvegicus

Synonyms: C-C motif chemokine 4, MIP-1-beta, Macrophage inflammatory protein 1-beta, Mip1-b, Mip1b, ...
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Disease relevance of Ccl4


High impact information on Ccl4


Chemical compound and disease context of Ccl4

  • Arteriosclerotic and nonarteriosclerotic rats were treated with carbon tetrachloride (CCL4) to induce cirrhosis of the liver [7].
  • The purpose of this study was 2-fold: (i) to determine whether the potent doublet of this cytokine, MIP-1beta, is actually produced in the brain in response to a pyrogenic dose of a lipopolysaccharide of Escherichia coli and (ii) to determine the anatomical site of synthesis of this cytokine in the brain [8].
  • The purpose of this study was to examine the action of an inhibitor of protein synthesis, anisomycin, on the pyrexia which follows intrahypothalamic injection of MIP-1 beta [9].
  • The results showed that anti-MIP-1beta failed to alter the PGE2 hyperthermia [10].
  • Micronodular cirrhosis was present in CCL4-treated rats with elevated AST and alkaline phosphatase levels [11].

Biological context of Ccl4


Anatomical context of Ccl4


Associations of Ccl4 with chemical compounds

  • Following the intense fever produced by intraperitoneal administration of lipopolysaccharide in the unrestrained rat, MIP-1beta immunoreactivity was identified post mortem in two regions of the brain implicated in fever: the organum vasculosum laminae terminalis (OVLT) and the anterior hypothalamic, preoptic area (AH/POA) [8].
  • When 10 mg/kg anisomycin was administered subcutaneously, the febrile response to 25 pg MIP-1 beta injected in the AH/POA was significantly suppressed [9].
  • After 3 to 7 weeks, the rats were injected with CCL4 (ip) and ethane was collected for 9 hours [16].
  • This dissociation supports the viewpoint that at least two distinct systems exist in the brain which underlie a febrile response: MIP-1beta underlies one component whereas PGE2 comprises the other [10].
  • Pyrazole treatment of rats potentiates CCL4-but not CHCL3-hepatotoxicity [17].

Other interactions of Ccl4


Analytical, diagnostic and therapeutic context of Ccl4


  1. Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats. Bless, N.M., Huber-Lang, M., Guo, R.F., Warner, R.L., Schmal, H., Czermak, B.J., Shanley, T.P., Crouch, L.D., Lentsch, A.B., Sarma, V., Mulligan, M.S., Friedl, H.P., Ward, P.A. J. Immunol. (2000) [Pubmed]
  2. Chemokine expression in rat stab wound brain injury. Ghirnikar, R.S., Lee, Y.L., He, T.R., Eng, L.F. J. Neurosci. Res. (1996) [Pubmed]
  3. Identification of cell types producing RANTES, MIP-1 alpha and MIP-1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization. Miyagishi, R., Kikuchi, S., Takayama, C., Inoue, Y., Tashiro, K. J. Neuroimmunol. (1997) [Pubmed]
  4. Protective effect of aprotinin on ischemic hepatocellular damage. Lie, T.S., Seger, R., Hong, G.S., Preissinger, H., Ogawa, K. Transplantation (1989) [Pubmed]
  5. Intrinsic responses to Borna disease virus infection of the central nervous system. Morimoto, K., Hooper, D.C., Bornhorst, A., Corisdeo, S., Bette, M., Fu, Z.F., Schäfer, M.K., Koprowski, H., Weihe, E., Dietzschold, B. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Hypothalamic interaction between macrophage inflammatory protein-1 alpha (MIP-1 alpha) and MIP-1 beta in rats: a new level for fever control? Miñano, F.J., Fernández-Alonso, A., Myers, R.D., Sancibrián, M. J. Physiol. (Lond.) (1996) [Pubmed]
  7. Effect of CCL4-induced cirrhosis on the pathophysiologic course of acute myocardial infarction in nonarteriosclerotic vs arteriosclerotic male rats. Wexler, B.C., Greenberg, B.P. Atherosclerosis (1979) [Pubmed]
  8. Macrophage inflammatory protein-1beta (MIP-1beta) produced endogenously in brain during E. coli fever in rats. Miñano, F.J., Fernández-Alonso, A., Benamar, K., Myers, R.K., Sancibrián, M., Ruiz, R.M., Armengol, J.A. Eur. J. Neurosci. (1996) [Pubmed]
  9. Fever induced in rats by intrahypothalamic macrophage inflammatory protein (MIP)-1 beta: role of protein synthesis. Fernández-Alonso, A., Miñano, F.J., Myers, R.D. J. Neurosci. Res. (1995) [Pubmed]
  10. Antibodies to macrophage inflammatory protein-1beta in preoptic area of rats fail to suppress PGE2 hyperthermia. Armengol, J.A., Benamar, K., Fernández-Alonso, A., Sancibrián, M., Myers, R.D., Miñano, F.J. Brain Res. (1997) [Pubmed]
  11. Plasma amino acids in long-term models for obstructive versus toxic liver injury in developing rats. Weisdorf, S.A., Freese, D.K., Radmer, W.J., Dehner, L.P., Cerra, F.B. J. Pediatr. Gastroenterol. Nutr. (1990) [Pubmed]
  12. Carbon tetrachloride-induced changes in mixed function oxidases and microsomal cytochromes in the rat lung. Chen, W.J., Chi, E.Y., Smuckler, E.A. Lab. Invest. (1977) [Pubmed]
  13. Differentiation of necrotic cell death with or without lysosomal activation: application of acute liver injury models induced by carbon tetrachloride (CCL4) and dimethylnitrosamine (DMN). Yasuda, M., Okabe, T., Itoh, J., Takekoshi, S., Hasegawa, H., Nagata, H., Osamura, R.Y., Watanabe, K. J. Histochem. Cytochem. (2000) [Pubmed]
  14. Effect of D-003, a mixture of high molecular weight primary acids from sugar cane wax, on CL4C-induced liver acute injury in rats. Noa, M., Mendoza, S., Más, R., Mendoza, N. Drugs under experimental and clinical research. (2002) [Pubmed]
  15. Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Bona, E., Andersson, A.L., Blomgren, K., Gilland, E., Puka-Sundvall, M., Gustafson, K., Hagberg, H. Pediatr. Res. (1999) [Pubmed]
  16. Protection against carbon tetrachloride-induced lipid peroxidation in the rat by dietary vitamin E, selenium, and methionine as measured by ethane evolution. Hafeman, D.G., Hoekstra, W.G. J. Nutr. (1977) [Pubmed]
  17. Pyrazole treatment of rats potentiates CCL4-but not CHCL3-hepatotoxicity. Ebel, R.E. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  18. RANTES: a new prostaglandin dependent endogenous pyrogen in the rat. Tavares, E., Miñano, F.J. Neuropharmacology (2000) [Pubmed]
  19. Effect of mu-selective opioid antagonists on MIP-1 beta and IL-1 beta-induced fever. Handler, C.M., Price, R.W., Geller, E.B., Adler, M.W. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  20. Effect of Sinai san decoction on the development of non-alcoholic steatohepatitis in rats. Zhang, Q., Zhao, Y., Zhang, D.B., Sun, L.J. World J. Gastroenterol. (2005) [Pubmed]
  21. Alteration of hepatic ethanol metabolism in CCL4-intoxicated rats: analysis using isolated liver perfusion system. Yuki, T., Hashimoto, T., Kuriyama, K., Ogasawara, T., Takino, T. Substance and alcohol actions/misuse. (1982) [Pubmed]
  22. Scanning electron microscopy of rat degenerated hepatocytes after carbon tetrachloride intoxication. Itoshima, T., Kiyotoshi, S., Kawaguchi, K., Ito, T., Ogawa, H., Nagashima, H., Yamamoto, K., Kobayashi, T., Murakami, T. Scanning electron microscopy. (1981) [Pubmed]
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