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Gene Review

Cnn1  -  calponin 1

Mus musculus

Synonyms: Basic calponin, CN, Calponin H1, smooth muscle, Calponin-1, CnnI, ...
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Disease relevance of Cnn1


Psychiatry related information on Cnn1

  • In the present study, we examined the effect of h1 calponin depletion on the metabolism and behavior of mice and found that the mutated mice showed increased locomotor activity, as well as increased intake of food and water, associated with the decreased number of neurons in the paraventricular nucleus of the hypothalamus (PVN) [4].

High impact information on Cnn1


Biological context of Cnn1


Anatomical context of Cnn1

  • In this report, we describe a unique pattern of Cnn1 expression during the growth and differentiation of BC3H1 cells, a mouse cell line that has transcriptional characteristics of both smooth and skeletal muscle lineages [5].
  • These results are the first to show reversible expression of Cnn1 and demonstrate the utility of the BC3H1 muscle cell line as a model system for the further characterization of Cnn1 gene regulation [5].
  • Among three isoforms of calponin, h2-calponin is found in both smooth muscle and non-muscle cells [8].
  • In particular, we frequently observed bleeding into the surrounding tissue from blood vessels of the ocular fundus in CN(-/-) mice [1].
  • We have observed weak expression of calponin h1, which stabilizes the actin filament system, in blood vessels within human malignant tumors [1].

Associations of Cnn1 with chemical compounds

  • Results from cycloheximide and actinomycin D studies suggest the existence of a labile repressor protein(s) that destabilizes the pool of Cnn1 mRNA and/or silences transcription of the Cnn1 locus [5].
  • When fluorescein was injected i.v. into mice, the CN(-/-) mice exhibited a greater and more rapid leakage of fluorescein from the blood vessels of the ocular fundus compared with the CN(+/+) mice [1].
  • Notably, expression of GFP h1 CaP, but not GFP h2 CaP, conferred increased resistance of the actin cytoskeleton to the actin polymerization antagonists cytochalasin B and latrunculin B, as well as to the protein kinase inhibitors H7-dihydrochloride and rho-kinase inhibitor Y-27632 [9].
  • Expressing functional domains of mouse calponin: involvement of the region around alanine 145 in the actomyosin ATPase inhibitory activity of calponin [10].
  • On the other hand, calponin bound strongly to nonfilamentous desmin tetramers and was incorporated into intermediate filaments when the two proteins were mixed in a buffer containing 6 M urea and dialyzed into a buffer containing 0.15 M NaCl [11].

Regulatory relationships of Cnn1


Other interactions of Cnn1


Analytical, diagnostic and therapeutic context of Cnn1


  1. Structural fragility of blood vessels and peritoneum in calponin h1-deficient mice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells. Taniguchi, S., Takeoka, M., Ehara, T., Hashimoto, S., Shibuki, H., Yoshimura, N., Shigematsu, H., Takahashi, K., Katsuki, M. Cancer Res. (2001) [Pubmed]
  2. Calponin h1 suppresses tumor growth of Src-induced transformed 3Y1 cells in association with a decrease in angiogenesis. Kaneko, M., Takeoka, M., Oguchi, M., Koganehira, Y., Murata, H., Ehara, T., Tozuka, M., Saida, T., Taniguchi, S. Jpn. J. Cancer Res. (2002) [Pubmed]
  3. Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma. Horiuchi, A., Nikaido, T., Taniguchi, S., Fujii, S. J. Natl. Cancer Inst. (1999) [Pubmed]
  4. Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice. Bannai, M., Yoshimoto, R., MiTSUI-SAITO, M., Hori, M., Nishihara, M., Takahashi, K., Yamamura, H., Taniguchi, S., Katsuki, M., Ozaki, H., Karaki, H. J. Vet. Med. Sci. (2003) [Pubmed]
  5. Expression and chromosomal mapping of the mouse smooth muscle calponin gene. Miano, J.M., Thomas, S., Disteche, C.M. Mamm. Genome (2001) [Pubmed]
  6. Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis. Miano, J.M., Olson, E.N. J. Biol. Chem. (1996) [Pubmed]
  7. Developmental pattern of expression and genomic organization of the calponin-h1 gene. A contractile smooth muscle cell marker. Samaha, F.F., Ip, H.S., Morrisey, E.E., Seltzer, J., Tang, Z., Solway, J., Parmacek, M.S. J. Biol. Chem. (1996) [Pubmed]
  8. h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. Hossain, M.M., Crish, J.F., Eckert, R.L., Lin, J.J., Jin, J.P. J. Biol. Chem. (2005) [Pubmed]
  9. Live dynamics of GFP-calponin: isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences. Danninger, C., Gimona, M. J. Cell. Sci. (2000) [Pubmed]
  10. Expressing functional domains of mouse calponin: involvement of the region around alanine 145 in the actomyosin ATPase inhibitory activity of calponin. el-Mezgueldi, M., Strasser, P., Fattoum, A., Gimona, M. Biochemistry (1996) [Pubmed]
  11. Association of calponin with desmin intermediate filaments. Mabuchi, K., Li, B., Ip, W., Tao, T. J. Biol. Chem. (1997) [Pubmed]
  12. Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation. Hossain, M.M., Hwang, D.Y., Huang, Q.Q., Sasaki, Y., Jin, J.P. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  13. AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Yamada, H., Akishita, M., Ito, M., Tamura, K., Daviet, L., Lehtonen, J.Y., Dzau, V.J., Horiuchi, M. Hypertension (1999) [Pubmed]
  14. Co-localization of immunoreactive forms of calponin with actin cytoskeleton in platelets, fibroblasts, and vascular smooth muscle. Takeuchi, K., Takahashi, K., Abe, M., Nishida, W., Hiwada, K., Nabeya, T., Maruyama, K. J. Biochem. (1991) [Pubmed]
  15. Adenovirus-mediated calponin h1 gene therapy directed against peritoneal dissemination of ovarian cancer: bifunctional therapeutic effects on peritoneal cell layer and cancer cells. Ogura, T., Kobayashi, H., Ueoka, Y., Okugawa, K., Kato, K., Hirakawa, T., Hashimoto, S., Taniguchi, S., Wake, N., Nakano, H. Clin. Cancer Res. (2006) [Pubmed]
  16. Altered expression of alpha-actin, smooth muscle myosin heavy chain-1 and calponin in cultured smooth muscle cells by oxidized low density lipoproteins. Damiani, E., Sugiyama, T., Shimamura, K., Greci, L., Matsuda, Y. FEBS Lett. (1998) [Pubmed]
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