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Gene Review

Fabp5  -  fatty acid binding protein 5, epidermal

Rattus norvegicus

Synonyms: C-FABP, Cutaneous fatty acid-binding protein, DA11, E-FABP, Epidermal-type fatty acid-binding protein, ...
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Disease relevance of Fabp5


High impact information on Fabp5


Biological context of Fabp5

  • The 0.7 kb DA11 full length cDNA clone contains a 405 nucleotide open reading frame that encodes a putative protein of 15.2 kDa (135 amino acid residues) and is a member of the family of fatty acid binding proteins (FABP) [6].
  • Expression of DA11, a neuronal-injury-induced fatty acid binding protein, coincides with axon growth and neuronal differentiation during central nervous system development [7].
  • The strong association of DA11 gene expression with development throughout the CNS suggests that this unique FABP plays an important role in axonal growth and neuronal differentiation in many different neuronal populations [7].
  • Transient upregulation of DA11 mRNA and protein levels in CNS tissues were quantified by Northern blot hybridization and Western immunoblot analyses at different developmental ages [7].
  • Epithelial/epidermal fatty acid-binding protein (E-FABP) is induced in peripheral neurons during nerve regeneration and is found at high levels in central neurons during neuronal migration and development [2].

Anatomical context of Fabp5


Associations of Fabp5 with chemical compounds

  • The status of the five cysteine residues in rat cutaneous fatty acid-binding protein was examined by chemical and mass-spectrometric analyses [8].
  • In the linoleic acid-deficient rats, TEWL did not increase and the expression pattern of C-FABP showed no notable change until 28 weeks after initiation of the diets, indicating that C-FABP expression may not be affected by altered essential fatty acid metabolism [9].

Co-localisations of Fabp5


Other interactions of Fabp5


Analytical, diagnostic and therapeutic context of Fabp5


  1. Identification of the messenger RNA for human cutaneous fatty acid-binding protein as a metastasis inducer. Jing, C., Beesley, C., Foster, C.S., Rudland, P.S., Fujii, H., Ono, T., Chen, H., Smith, P.H., Ke, Y. Cancer Res. (2000) [Pubmed]
  2. Induction and axonal localization of epithelial/epidermal fatty acid-binding protein in retinal ganglion cells are associated with axon development and regeneration. Allen, G.W., Liu, J., Kirby, M.A., De León, M. J. Neurosci. Res. (2001) [Pubmed]
  3. Vaccinia virus infection and gene transduction in cultured neurons. Allen, G.A., Denes, B., Fodor, I., De Leon, M. Microbes Infect. (2005) [Pubmed]
  4. Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells. Jing, C., Beesley, C., Foster, C.S., Chen, H., Rudland, P.S., West, D.C., Fujii, H., Smith, P.H., Ke, Y. Cancer Res. (2001) [Pubmed]
  5. Induction of epidermal fatty acid binding protein in intravascular monocytes of renal allografts. Grau, V., Garn, H., Bette, M., Spener, F., Steiniger, B., Gemsa, D., Stehling, O. Transplantation (2003) [Pubmed]
  6. Fatty acid binding protein is induced in neurons of the dorsal root ganglia after peripheral nerve injury. De León, M., Welcher, A.A., Nahin, R.H., Liu, Y., Ruda, M.A., Shooter, E.M., Molina, C.A. J. Neurosci. Res. (1996) [Pubmed]
  7. Expression of DA11, a neuronal-injury-induced fatty acid binding protein, coincides with axon growth and neuronal differentiation during central nervous system development. Liu, Y., Molina, C.A., Welcher, A.A., Longo, L.D., De Leon, M. J. Neurosci. Res. (1997) [Pubmed]
  8. Disulfide bonds in rat cutaneous fatty acid-binding protein. Odani, S., Namba, Y., Ishii, A., Ono, T., Fujii, H. J. Biochem. (2000) [Pubmed]
  9. High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin. Yamaguchi, H., Yamamoto, A., Watanabe, R., Uchiyama, N., Fujii, H., Ono, T., Ito, M. J. Dermatol. Sci. (1998) [Pubmed]
  10. DNA array analysis of changes in preovulatory gene expression in the rat ovary. Leo, C.P., Pisarska, M.D., Hsueh, A.J. Biol. Reprod. (2001) [Pubmed]
  11. In situ and immunocytochemical localization of E-FABP mRNA and protein during neuronal migration and differentiation in the rat brain. Liu, Y., Longo, L.D., De León, M. Brain Res. (2000) [Pubmed]
  12. Stabilization of leukotriene A4 by epithelial fatty acid-binding protein in the rat basophilic leukemia cell. Dickinson Zimmer, J.S., Voelker, D.R., Bernlohr, D.A., Murphy, R.C. J. Biol. Chem. (2004) [Pubmed]
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