Gene Review:
Fkbp1a - FK506 binding protein 1a
Mus musculus
Synonyms:
12 kDa FK506-binding protein, 12 kDa FKBP, Calstabin-1, FK506-binding protein 1A, FKBP-12, ...
- Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects. Hamilton, G.S., Wu, Y.Q., Limburg, D.C., Wilkinson, D.E., Vaal, M.J., Li, J.H., Thomas, C., Huang, W., Sauer, H., Ross, D.T., Soni, R., Chen, Y., Guo, H., Howorth, P., Valentine, H., Liang, S., Spicer, D., Fuller, M., Steiner, J.P. J. Med. Chem. (2002)
- The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin. Dumont, F.J., Staruch, M.J., Koprak, S.L., Siekierka, J.J., Lin, C.S., Harrison, R., Sewell, T., Kindt, V.M., Beattie, T.R., Wyvratt, M. J. Exp. Med. (1992)
- The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. Fruman, D.A., Bierer, B.E., Benes, J.E., Burakoff, S.J., Austen, K.F., Katz, H.R. J. Immunol. (1995)
- Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with a putative signal sequence expressed in differentiating F9 cells. Schumacher, A., Schröter, H., Multhaup, G., Nordheim, A. Biochim. Biophys. Acta (1991)
- Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy. Xin, H.B., Senbonmatsu, T., Cheng, D.S., Wang, Y.X., Copello, J.A., Ji, G.J., Collier, M.L., Deng, K.Y., Jeyakumar, L.H., Magnuson, M.A., Inagami, T., Kotlikoff, M.I., Fleischer, S. Nature (2002)
- A yeast sensor of ligand binding. Tucker, C.L., Fields, S. Nat. Biotechnol. (2001)
- Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family. Fong, S., Mounkes, L., Liu, Y., Maibaum, M., Alonzo, E., Desprez, P.Y., Thor, A.D., Kashani-Sabet, M., Debs, R.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The InsP3 receptor and intracellular Ca2+ signaling. Mikoshiba, K. Curr. Opin. Neurobiol. (1997)
- FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. Xu, X., Su, B., Barndt, R.J., Chen, H., Xin, H., Yan, G., Chen, L., Cheng, D., Heitman, J., Zhuang, Y., Fleischer, S., Shou, W. Transplantation (2002)
- Ca(2+)-dependent interaction between FKBP12 and calcineurin regulates activity of the Ca(2+) release channel in skeletal muscle. Shin, D.W., Pan, Z., Bandyopadhyay, A., Bhat, M.B., Kim, d.o. .H., Ma, J. Biophys. J. (2002)
- Comparative analysis of enzyme activities and mRNA levels of peptidyl prolyl cis/trans isomerases in various organs of wild type and Pin1-/- mice. Fanghänel, J., Akiyama, H., Uchida, C., Uchida, T. FEBS Lett. (2006)
- Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Kaye, R.E., Fruman, D.A., Bierer, B.E., Albers, M.W., Zydowsky, L.D., Ho, S.I., Jin, Y.J., Castells, M.C., Schreiber, S.L., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Targeted expansion of genetically modified bone marrow cells. Jin, L., Siritanaratkul, N., Emery, D.W., Richard, R.E., Kaushansky, K., Papayannopoulou, T., Blau, C.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation. Luo, Z.D., Wang, Y., Werlen, G., Camp, S., Chien, K.R., Taylor, P. Mol. Pharmacol. (1999)
- FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. Bassing, C.H., Shou, W., Muir, S., Heitman, J., Matzuk, M.M., Wang, X.F. Cell Growth Differ. (1998)
- Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands. Wu, Y.Q., Wilkinson, D.E., Limburg, D., Li, J.H., Sauer, H., Ross, D., Liang, S., Spicer, D., Valentine, H., Fuller, M., Guo, H., Howorth, P., Soni, R., Chen, Y., Steiner, J.P., Hamilton, G.S. J. Med. Chem. (2002)
- FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Wang, Y.X., Zheng, Y.M., Mei, Q.B., Wang, Q.S., Collier, M.L., Fleischer, S., Xin, H.B., Kotlikoff, M.I. Am. J. Physiol., Cell Physiol. (2004)
- Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice. Sauer, H., Francis, J.M., Jiang, H., Hamilton, G.S., Steiner, J.P. Brain Res. (1999)
- Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects. Wilkinson, D.E., Thomas, B.E., Limburg, D.C., Holmes, A., Sauer, H., Ross, D.T., Soni, R., Chen, Y., Guo, H., Howorth, P., Valentine, H., Spicer, D., Fuller, M., Steiner, J.P., Hamilton, G.S., Wu, Y.Q. Bioorg. Med. Chem. (2003)
- Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice. Kamsler, A., Segal, M. J. Neurosci. (2003)
- FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle. Aghdasi, B., Ye, K., Resnick, A., Huang, A., Ha, H.C., Guo, X., Dawson, T.M., Dawson, V.L., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Kugimiya, F., Yano, F., Ohba, S., Igawa, K., Nakamura, K., Kawaguchi, H., Chung, U.I. Biochem. Biophys. Res. Commun. (2005)
- Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region. Banholzer, R., Nair, A.P., Hirsch, H.H., Ming, X.F., Moroni, C. Mol. Cell. Biol. (1997)
- Stimulating cell proliferation through the pharmacologic activation of c-kit. Jin, L., Asano, H., Blau, C.A. Blood (1998)
- Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line. Fessenden, J.D., Wang, Y., Moore, R.A., Chen, S.R., Allen, P.D., Pessah, I.N. Biophys. J. (2000)
- The effects of rapamycin in murine peripheral nerve isografts and allografts. Myckatyn, T.M., Ellis, R.A., Grand, A.G., Sen, S.K., Lowe, J.B., Hunter, D.A., Mackinnon, S.E. Plast. Reconstr. Surg. (2002)