Gene Review:
Hexb - hexosaminidase B
Mus musculus
Synonyms:
Beta-N-acetylhexosaminidase subunit beta, Beta-hexosaminidase subunit beta, Hexosaminidase subunit B, N-acetyl-beta-glucosaminidase subunit beta
- Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases. Phaneuf, D., Wakamatsu, N., Huang, J.Q., Borowski, A., Peterson, A.C., Fortunato, S.R., Ritter, G., Igdoura, S.A., Morales, C.R., Benoit, G., Akerman, B.R., Leclerc, D., Hanai, N., Marth, J.D., Trasler, J.M., Gravel, R.A. Hum. Mol. Genet. (1996)
- Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. Yamaguchi, A., Katsuyama, K., Nagahama, K., Takai, T., Aoki, I., Yamanaka, S. J. Clin. Invest. (2004)
- Diabetic microangiopathy in KK mice. VI. Effect of glycemic control on renal glycoprotein metabolism and established glomerulosclerosis. Reddi, A.S., Velasco, C.A., Reddy, P.R., Khan, M.Y., Camerini-Davalos, R.A. Exp. Mol. Pathol. (1990)
- Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis. Sango, K., McDonald, M.P., Crawley, J.N., Mack, M.L., Tifft, C.J., Skop, E., Starr, C.M., Hoffmann, A., Sandhoff, K., Suzuki, K., Proia, R.L. Nat. Genet. (1996)
- Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Sango, K., Yamanaka, S., Hoffmann, A., Okuda, Y., Grinberg, A., Westphal, H., McDonald, M.P., Crawley, J.N., Sandhoff, K., Suzuki, K., Proia, R.L. Nat. Genet. (1995)
- Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment. Liu, Y., Hoffmann, A., Grinberg, A., Westphal, H., McDonald, M.P., Miller, K.M., Crawley, J.N., Sandhoff, K., Suzuki, K., Proia, R.L. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes. Gilbert, F., Kucherlapati, R., Creagan, R.P., Murnane, M.J., Darlington, G.J., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (1975)
- Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases. Huang, J.Q., Trasler, J.M., Igdoura, S., Michaud, J., Hanal, N., Gravel, R.A. Hum. Mol. Genet. (1997)
- Elevation of lung surfactant phosphatidylcholine in mouse models of Sandhoff and of Niemann-Pick A disease. Buccoliero, R., Ginzburg, L., Futerman, A.H. J. Inherit. Metab. Dis. (2004)
- Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides. Trasler, J., Saberi, F., Somani, I.H., Adamali, H.I., Huang, J.Q., Fortunato, S.R., Ritter, G., Gu, M., Aebersold, R., Gravel, R.A., Hermo, L. Endocrinology (1998)
- Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. Pelled, D., Lloyd-Evans, E., Riebeling, C., Jeyakumar, M., Platt, F.M., Futerman, A.H. J. Biol. Chem. (2003)
- Development of infertility at young adult age in a mouse model of human Sandhoff disease. Juneja, S.C. Reprod. Fertil. Dev. (2002)
- An inducible mouse model of late onset Tay-Sachs disease. Jeyakumar, M., Smith, D., Eliott-Smith, E., Cortina-Borja, M., Reinkensmeier, G., Butters, T.D., Lemm, T., Sandhoff, K., Perry, V.H., Dwek, R.A., Platt, F.M. Neurobiol. Dis. (2002)
- I. Abnormalities in cells of the testis, efferent ducts, and epididymis in juvenile and adult mice with beta-hexosaminidase A and B deficiency. Adamali, H.I., Somani, I.H., Huang, J.Q., Mahuran, D., Gravel, R.A., Trasler, J.M., Hermo, L. J. Androl. (1999)
- Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice. Denny, C.A., Kasperzyk, J.L., Gorham, K.N., Bronson, R.T., Seyfried, T.N. J. Neurosci. Res. (2006)
- The use of urinary N-acetyl-beta-glucosaminidase in human renal toxicology. II. Elevation in human excretion after aspirin and sodium salicylate. Lockwood, T.D., Bosmann, H.B. Toxicol. Appl. Pharmacol. (1979)
- Reduction of N-acetyl-beta-glucosaminidase activity in the submaxillary glands of streptozotocin diabetic mice. Hatakeyama, K., Hiramatsu, M., Minami, N. J. Biochem. (1980)
- Assignment of genes encoding dihydrofolate reductase and hexosaminidase B to Mus musculus chromosome 13. Killary, A.M., Leach, R.J., Moran, R.G., Fournier, R.E. Somat. Cell Mol. Genet. (1986)
- Analyses of bronchoalveolar lavage fluid (BALF) in MRL-lpr/lpr mice. Takaishi, M., Awaya, Y., Ishioka, S., Hozawa, S., Oyama, T., Takahashi, K., Maeda, H., Yamakido, M. Autoimmunity (1991)
- Lysosomal enzymes in experimental diabetic cardiomyopathy. Giacomelli, F., Skoza, L., Wiener, J. Clin. Biochem. (1980)
- Sperm require beta-N-acetylglucosaminidase to penetrate through the egg zona pellucida. Miller, D.J., Gong, X., Shur, B.D. Development (1993)