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Gene Review

Il2rg  -  interleukin 2 receptor, gamma chain

Mus musculus

Synonyms: CD132, Cytokine receptor common subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, ...
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Disease relevance of Il2rg


High impact information on Il2rg


Biological context of Il2rg


Anatomical context of Il2rg


Associations of Il2rg with chemical compounds


Physical interactions of Il2rg


Regulatory relationships of Il2rg


Other interactions of Il2rg


Analytical, diagnostic and therapeutic context of Il2rg


  1. Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor gamma chain-deficient mice. Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., Suda, T., Yamamura, K., Tomita, K. International journal of experimental pathology. (1997) [Pubmed]
  2. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. Zeng, R., Spolski, R., Finkelstein, S.E., Oh, S., Kovanen, P.E., Hinrichs, C.S., Pise-Masison, C.A., Radonovich, M.F., Brady, J.N., Restifo, N.P., Berzofsky, J.A., Leonard, W.J. J. Exp. Med. (2005) [Pubmed]
  3. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., Kiyono, H. Gastroenterology (2005) [Pubmed]
  4. Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes. Bregenholt, S., Berche, P., Brombacher, F., Di Santo, J.P. J. Immunol. (2001) [Pubmed]
  5. Expression of the mouse interleukin-2 receptor gamma chain in insect cells using a baculovirus expression vector--comparison with the human common gamma chain. Stenroos, K., West, A., Raivio, E., Lindqvist, C. Scand. J. Immunol. (1997) [Pubmed]
  6. Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S., Sugamura, K. Science (1994) [Pubmed]
  7. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Rodewald, H.R., Ogawa, M., Haller, C., Waskow, C., DiSanto, J.P. Immunity (1997) [Pubmed]
  8. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. Kondo, M., Akashi, K., Domen, J., Sugamura, K., Weissman, I.L. Immunity (1997) [Pubmed]
  9. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., Rudensky, A.Y. Nat. Immunol. (2005) [Pubmed]
  10. The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus. DiSanto, J.P., Certain, S., Wilson, A., MacDonald, H.R., Avner, P., Fischer, A., de Saint Basile, G. Eur. J. Immunol. (1994) [Pubmed]
  11. Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. Blagoev, B., Nielsen, M.M., Angrist, M., Chakravarti, A., Pandey, A. Gene (2002) [Pubmed]
  12. Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise. Miyazaki, S., Tanebe, K., Sakai, M., Michimata, T., Tsuda, H., Fujimura, M., Nakamura, M., Kiso, Y., Saito, S. Am. J. Reprod. Immunol. (2002) [Pubmed]
  13. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. Nakajima, H., Shores, E.W., Noguchi, M., Leonard, W.J. J. Exp. Med. (1997) [Pubmed]
  14. Role of common cytokine receptor gamma chain (gamma(c))- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. Suzuki, K., Nakajima, H., Watanabe, N., Kagami, S., Suto, A., Saito, Y., Saito, T., Iwamoto, I. Blood (2000) [Pubmed]
  15. Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo. Vosshenrich, C.A., Ranson, T., Samson, S.I., Corcuff, E., Colucci, F., Rosmaraki, E.E., Di Santo, J.P. J. Immunol. (2005) [Pubmed]
  16. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. Taylor, R.T., Lügering, A., Newell, K.A., Williams, I.R. J. Immunol. (2004) [Pubmed]
  17. Expression of the common cytokine receptor gamma chain by murine dendritic cells including epidermal Langerhans cells. Mohamadzadeh, M., Ariizumi, K., Sugamura, K., Bergstresser, P.R., Takashima, A. Eur. J. Immunol. (1996) [Pubmed]
  18. Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. Rodewald, H.R., Waskow, C., Haller, C. J. Exp. Med. (2001) [Pubmed]
  19. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. Noguchi, M., Sarin, A., Aman, M.J., Nakajima, H., Shores, E.W., Henkart, P.A., Leonard, W.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  20. Purification of a 64 kDa antigen from Trypanosoma evansi that exhibits cross-reactivity with Trypanosoma vivax. Uzcanga, G., Mendoza, M., Aso, P.M., Bubis, J. Parasitology (2002) [Pubmed]
  21. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. Di Santo, J.P., Aifantis, I., Rosmaraki, E., Garcia, C., Feinberg, J., Fehling, H.J., Fischer, A., von Boehmer, H., Rocha, B. J. Exp. Med. (1999) [Pubmed]
  22. The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death. Dai, Z., Arakelov, A., Wagener, M., Konieczny, B.T., Lakkis, F.G. J. Immunol. (1999) [Pubmed]
  23. Transfer of interleukin 2 receptor genes into squamous cell carcinoma. Modification of tumor cell growth. Lin, W.C., Yasumura, S., Whiteside, T.L. Arch. Otolaryngol. Head Neck Surg. (1993) [Pubmed]
  24. Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. Boesteanu, A., Silva, A.D., Nakajima, H., Leonard, W.J., Peschon, J.J., Joyce, S. J. Exp. Med. (1997) [Pubmed]
  25. Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells. Pelletier, M., Girard, D. J. Immunol. (2006) [Pubmed]
  26. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice. Nakajima, H., Leonard, W.J. J. Immunol. (1997) [Pubmed]
  27. Common cytokine receptor gamma chain (gamma c)-dependent cytokines: understanding in vivo functions by gene targeting. Di Santo, J.P., Kühn, R., Müller, W. Immunol. Rev. (1995) [Pubmed]
  28. The uterine NK cell population requires IL-15 but these cells are not required for pregnancy nor the resolution of a Listeria monocytogenes infection. Barber, E.M., Pollard, J.W. J. Immunol. (2003) [Pubmed]
  29. delta 9-Tetrahydrocannabinol (THC) causes the variable expression of IL2 receptor subunits. Zhu, W., Igarashi, T., Friedman, H., Klein, T.W. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  30. Development of vaccines and passive immunotherapy against SARS coronavirus using mouse and SCID-PBL/hu mouse models. Okada, M., Takemoto, Y., Okuno, Y., Hashimoto, S., Fukunaga, Y., Tanaka, T., Kita, Y., Kuwayama, S., Muraki, Y., Kanamaru, N., Takai, H., Okada, C., Sakaguchi, Y., Furukawa, I., Yamada, K., Izumiya, M., Yoshida, S., Matsumoto, M., Kase, T., Peiris, J.S., DeMello, D.E., Chen, P.J., Yamamoto, N., Yoshinaka, Y., Nomura, T., Ishida, I., Morikawa, S., Tashiro, M., Sakatani, M. Adv. Exp. Med. Biol. (2006) [Pubmed]
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