Gene Review:
Pltp - phospholipid transfer protein
Mus musculus
Synonyms:
Bpife, Lipid transfer protein II, OD107, Phospholipid transfer protein
- Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Jiang, X.C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X., Tall, A.R. Nat. Med. (2001)
- Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice. Desrumaux, C., Risold, P.Y., Schroeder, H., Deckert, V., Masson, D., Athias, A., Laplanche, H., Le Guern, N., Blache, D., Jiang, X.C., Tall, A.R., Desor, D., Lagrost, L. FASEB J. (2005)
- Phospholipid-transfer activities in cytosols from lung, isolated alveolar type II cells and alveolar type II cell-derived adenomas. Pool, G.L., Bubacz, D.G., Lumb, R.H., Mason, R.J. Biochem. J. (1983)
- Studies on the turnover of endogenous choline-containing phospholipids of cultured neuroblastoma cells. D'Souza, C.J., Clarke, J.T., Cook, H.W., Spence, M.W. Biochim. Biophys. Acta (1983)
- Plasma lipid transfer proteins. Jiang, X.C., Zhou, H.W. Curr. Opin. Lipidol. (2006)
- MTP regulated by an alternate promoter is essential for NKT cell development. Dougan, S.K., Rava, P., Hussain, M.M., Blumberg, R.S. J. Exp. Med. (2007)
- Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. Jiang, X.C., Bruce, C., Mar, J., Lin, M., Ji, Y., Francone, O.L., Tall, A.R. J. Clin. Invest. (1999)
- Phospholipid transfer protein-mediated incorporation and subcellular distribution of exogenous phosphatidylcholine and sphingomyelin in cultured neuroblastoma cells. D'Souza, C., Clarke, J.T., Cook, H.W., Spence, M.W. Biochim. Biophys. Acta (1983)
- Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides. Lie, J., Moerland, M., van Gent, T., van Haperen, R., Scheek, L., Sadeghi-Niaraki, F., de Crom, R., van Tol, A. Biochim. Biophys. Acta (2006)
- Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Ma, K., Cilingiroglu, M., Otvos, J.D., Ballantyne, C.M., Marian, A.J., Chan, L. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. Jiang, X.C., Bruce, C. J. Biol. Chem. (1995)
- Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. Jiang, X.C., Tall, A.R., Qin, S., Lin, M., Schneider, M., Lalanne, F., Deckert, V., Desrumaux, C., Athias, A., Witztum, J.L., Lagrost, L. J. Biol. Chem. (2002)
- The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Laffitte, B.A., Joseph, S.B., Chen, M., Castrillo, A., Repa, J., Wilpitz, D., Mangelsdorf, D., Tontonoz, P. Mol. Cell. Biol. (2003)
- Phospholipid transfer protein is regulated by liver X receptors in vivo. Cao, G., Beyer, T.P., Yang, X.P., Schmidt, R.J., Zhang, Y., Bensch, W.R., Kauffman, R.F., Gao, H., Ryan, T.P., Liang, Y., Eacho, P.I., Jiang, X.C. J. Biol. Chem. (2002)
- Phospholipid transfer protein (PLTP) mRNA expression is stimulated by developing embryos in the oviduct. Lee, K.F., Kwok, K.L., Chung, M.K., Lee, Y.L., Chow, J.F., Yeung, W.S. J. Cell. Biochem. (2005)
- Phospholipid transfer protein deficiency reduces sperm motility and impairs fertility of mouse males. Drouineaud, V., Lagrost, L., Klein, A., Desrumaux, C., Le Guern, N., Athias, A., Ménétrier, F., Moiroux, P., Sagot, P., Jimenez, C., Masson, D., Deckert, V. FASEB J. (2006)
- Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. Qin, S., Kawano, K., Bruce, C., Lin, M., Bisgaier, C., Tall, A.R., Jiang, X. J. Lipid Res. (2000)
- Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants. Jiang, X.C., Li, Z., Liu, R., Yang, X.P., Pan, M., Lagrost, L., Fisher, E.A., Williams, K.J. J. Biol. Chem. (2005)
- Effect of acute Chlamydia pneumoniae infection on lipoprotein metabolism in NIH/S mice. Tiirola, T., Erkkilä, L., Laitinen, K., Leinonen, M., Saikku, P., Bloigu, A., Jauhiainen, M. Scand. J. Clin. Lab. Invest. (2002)
- Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein. Siggins, S., Bykov, I., Hermansson, M., Somerharju, P., Lindros, K., Miettinen, T.A., Jauhiainen, M., Olkkonen, V.M., Ehnholm, C. Atherosclerosis (2007)
- Increased atherosclerotic lesions in apoE mice with plasma phospholipid transfer protein overexpression. Yang, X.P., Yan, D., Qiao, C., Liu, R.J., Chen, J.G., Li, J., Schneider, M., Lagrost, L., Xiao, X., Jiang, X.C. Arterioscler. Thromb. Vasc. Biol. (2003)
- Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. Mak, P.A., Kast-Woelbern, H.R., Anisfeld, A.M., Edwards, P.A. J. Lipid Res. (2002)
- Introduction of the human PLTP transgene suppresses the atherogenic diet-induced increase in plasma phospholipid transfer activity in C57BL/6 mice. Tu, A.Y., Paigen, B., Wolfbauer, G., Cheung, M.C., Kennedy, H., Chen, H., Albers, J.J. Int. J. Clin. Lab. Res. (1999)
- Atheroprotective potential of macrophage-derived phospholipid transfer protein in low-density lipoprotein receptor-deficient mice is overcome by apolipoprotein AI overexpression. Valenta, D.T., Ogier, N., Bradshaw, G., Black, A.S., Bonnet, D.J., Lagrost, L., Curtiss, L.K., Desrumaux, C.M. Arterioscler. Thromb. Vasc. Biol. (2006)