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Gene Review

MCF2L  -  MCF.2 cell line derived transforming...

Homo sapiens

Synonyms: ARHGEF14, DBL's big sister, DBS, Guanine nucleotide exchange factor DBS, KIAA0362, ...
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Disease relevance of MCF2L


Psychiatry related information on MCF2L

  • CONCLUSIONS: In advanced Parkinson's disease, chronic STN-DBS is associated with subjective improvement in sleep quality, probably through increased nocturnal mobility and reduction of sleep fragmentation [6].
  • Our results indicate that STN-DBS induces a significant improvement in motor performance of reaction time tasks in PD patients [7].
  • Patients with dementia, cognitive performance suggestive of an additional neuropathological process, or significant psychiatric impairments should not undergo DBS [8].
  • CONCLUSIONS: Significant QOL improvements after STN-DBS are associated with improved motor 'on' state and depressive symptoms [9].
  • The authors finally present a completely new indication for DBS: Tourette syndrome (TS) [10].

High impact information on MCF2L

  • The DBS motif is critical for the autoregulation, whereas the TATA box may act as an attenuating element for the autoregulatory loop [11].
  • Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a highly effective surgical treatment in patients with advanced Parkinson's disease (PD) [12].
  • These data suggest an activating effect of DBS upon its target structures and confirm a central role of the STN in motor as well as associative, limbic, and cerebellar basal ganglia circuits [12].
  • In the STN-DBS on-condition, clusters of significantly increased rCMRGlc were found in both lower thalami reaching down to the midbrain area and remote from the stimulation site in the right frontal cortex, temporal cortex, and parietal cortex, whereas rCMRGlc significantly decreased in the left rostral cerebellum [12].
  • Increases in network activation and learning performance occurred with internal pallidal deep brain stimulation (GPi DBS); decrements in these measures were present with levodopa [13].

Chemical compound and disease context of MCF2L


Biological context of MCF2L

  • Conversely, transfection of an isolated DH domain of Dbs induced JNK activation [17].
  • Additionally, DH and PH domain deficient Dbs blocked the receptor-induced inhibition of cell proliferation, while DH domain of Dbs inhibited cell proliferation via the JNK-dependent pathway [17].
  • The DBS sequence, which is located downstream of the pgRNA polyadenylation site, overlaps the core (C) protein coding region [18].
  • We previously identified two sequences, UBS and DBS (upstream and downstream binding sites), present in multiple copies in and adjacent to the pregenomic RNA (pgRNA) terminal redundancy, that were specifically recognized by a 65-kDa host factor, p65 [18].
  • Thus, the 5' UBS but not DBS sites play important cis-acting roles in HBV DNA replication; however, the involvement of p65 in these roles remains a matter for investigation [18].

Anatomical context of MCF2L

  • Preliminary reports of the effect of globus pallidus pars interna deep brain stimulation (GPi DBS) have also been promising [19].
  • Increases in OST protein were visualized by confocal microscopy at the plasma membrane [20].
  • Therefore, we evaluated the effect of DBS of the thalamus in 38 patients with essential head tremor [21].
  • As predicted, the DBS perturbation resulted in an enhancement of the ongoing soleus-muscle activity, and the unexpected tibialis anterior burst that was observed during the DBU paradigm was absent [22].
  • We have developed an allorestricted human CTL clone, DBS 1.5, that recognizes an epitope found on HLA-A3+ kidney epithelial cells but not on HLA identical B-lymphoblastoid cells [23].

Associations of MCF2L with chemical compounds

  • Stimulation of the alpha1B-adrenergic receptor enhanced an intrinsic Cdc42-GEF activity of Dbs in a manner dependent on Src family tyrosine kinases [17].
  • Therefore, STN-DBS was found to suppress cerebellar hypermetabolism and to partly restore physiologic glucose consumption in limbic and associative projection territories of the basal ganglia [12].
  • In contrast, inactivation of loci encoding an oligopeptide transporter, a purine repressor, and lantibiotic biosynthesis had no substantial impact on the capacity of OST mutants to survive within IE vegetations [24].
  • Furthermore, OST mRNAs were induced in human ileal biopsies exposed to the bile acid chenodeoxycholic acid [25].
  • The antitumor effect of the combination of cisplatin and caffeine was examined in OST transplanted to BALB/C athymic mice [14].

Other interactions of MCF2L


Analytical, diagnostic and therapeutic context of MCF2L

  • Nondestructive, electrical stimulation (deep brain stimulation; DBS) has proven an effective alternative to ablative surgery for neurological indications, suggesting potential utility in place of capsulotomy for OCD [26].
  • DBS and diathermy interaction induces severe CNS damage [27].
  • A patient with severe postanoxic dystonia and bilateral necrosis of the basal ganglia, who was confined to a wheelchair, underwent bilateral ventralis oralis anterior deep brain stimulation (Voa-DBS) after 6 weeks of unsuccessful bilateral pallidal DBS (GPi-DBS) [28].
  • Applying SCORE or OST 75% of the women would have to be referred for densitometry to identify 90% of the women with T-score < or = -2.0 (or T-score < or = -2.5) in at least one region [29].
  • The myth of microelectrode recording in ensuring a precise location of the DBS electrode within the sensorimotor part of the subthalamic nucleus [30].


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  2. Subthalamic DBS replaces levodopa in Parkinson's disease. Kleiner-Fisman, G., Saint-Cyr, J.A., Miyasaki, J., Lozano, A., Lang, A.E. Neurology (2002) [Pubmed]
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  6. Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation. Iranzo, A., Valldeoriola, F., Santamaría, J., Tolosa, E., Rumià, J. J. Neurol. Neurosurg. Psychiatr. (2002) [Pubmed]
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  9. Effect of motor improvement on quality of life following subthalamic stimulation is mediated by changes in depressive symptomatology. Tröster, A.I., Fields, J.A., Wilkinson, S., Pahwa, R., Koller, W.C., Lyons, K.E. Stereotactic and functional neurosurgery. (2003) [Pubmed]
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  12. Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease. Hilker, R., Voges, J., Weisenbach, S., Kalbe, E., Burghaus, L., Ghaemi, M., Lehrke, R., Koulousakis, A., Herholz, K., Sturm, V., Heiss, W.D. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
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  15. The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro. Sonnemann, J., Eckervogt, V., Truckenbrod, B., Boos, J., Winkelmann, W., van Valen, F. Anticancer Drugs (2001) [Pubmed]
  16. Biliary secretion in elasmobranchs. II. Hepatic uptake and biliary excretion of organic anions. Boyer, J.L., Schwarz, J., Smith, N. Am. J. Physiol. (1976) [Pubmed]
  17. Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase. Yamauchi, J., Hirasawa, A., Miyamoto, Y., Kokubu, H., Nishii, H., Okamoto, M., Sugawara, Y., Tsujimoto, G., Itoh, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  18. Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis. Perri, S., Ganem, D. J. Virol. (1997) [Pubmed]
  19. Deep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease. Kumar, R., Lang, A.E., Rodriguez-Oroz, M.C., Lozano, A.M., Limousin, P., Pollak, P., Benabid, A.L., Guridi, J., Ramos, E., van der Linden, C., Vandewalle, A., Caemaert, J., Lannoo, E., van den Abbeele, D., Vingerhoets, G., Wolters, M., Obeso, J.A. Neurology (2000) [Pubmed]
  20. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Boyer, J.L., Trauner, M., Mennone, A., Soroka, C.J., Cai, S.Y., Moustafa, T., Zollner, G., Lee, J.Y., Ballatori, N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  21. Efficacy of unilateral deep brain stimulation of the VIM nucleus of the thalamus for essential head tremor. Koller, W.C., Lyons, K.E., Wilkinson, S.B., Pahwa, R. Mov. Disord. (1999) [Pubmed]
  22. Early corrective reactions of the leg to perturbations at the torso during walking in humans. Misiaszek, J.E., Stephens, M.J., Yang, J.F., Pearson, K.G. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2000) [Pubmed]
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  25. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Landrier, J.F., Eloranta, J.J., Vavricka, S.R., Kullak-Ublick, G.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  26. Deep brain stimulation for refractory obsessive-compulsive disorder. Abelson, J.L., Curtis, G.C., Sagher, O., Albucher, R.C., Harrigan, M., Taylor, S.F., Martis, B., Giordani, B. Biol. Psychiatry (2005) [Pubmed]
  27. DBS and diathermy interaction induces severe CNS damage. Nutt, J.G., Anderson, V.C., Peacock, J.H., Hammerstad, J.P., Burchiel, K.J. Neurology (2001) [Pubmed]
  28. Postanoxic generalized dystonia improved by bilateral Voa thalamic deep brain stimulation. Ghika, J., Villemure, J.G., Miklossy, J., Temperli, P., Pralong, E., Christen-Zaech, S., Pollo, C., Maeder, P., Bogousslavsky, J., Vingerhoets, F. Neurology (2002) [Pubmed]
  29. Performance of four clinical screening tools to select peri- and early postmenopausal women for dual X-ray absorptiometry. Rud, B., Jensen, J.E., Mosekilde, L., Nielsen, S.P., Hilden, J., Abrahamsen, B. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2005) [Pubmed]
  30. The myth of microelectrode recording in ensuring a precise location of the DBS electrode within the sensorimotor part of the subthalamic nucleus. Hariz, M., Blomstedt, P., Limousin, P. Mov. Disord. (2004) [Pubmed]
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