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Gene Review

Ets1  -  v-ets avian erythroblastosis virus E26...

Rattus norvegicus

Synonyms: Ets-1, Etsoncb, Protein C-ets-1, Tpl1, p54
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Disease relevance of Ets1


High impact information on Ets1

  • We have used a range of methods to demonstrate a strong binding between p62 and p54 in this complex and show that the rod domain of p62 appears to constitute the principal binding site for p54 [5].
  • Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression [6].
  • The Ets-1-GHF-1 synergy requires a composite Ets-1-GHF-1 cis element and is dependent on an Ets-1-specific protein domain [6].
  • A 4- or 10-bp insertion between muE3 and muB inactivated the mu enhancer in S194 plasma cells but did not affect in vitro binding of Ets-1, PU.1, or the muE3-binding protein TFE3, alone or in pairwise combinations [7].
  • Ets-1 mRNA abundance was induced with a peak at 2 hours after stimulation with platelet-derived growth factor-BB and with angiotensin II [8].

Chemical compound and disease context of Ets1


Biological context of Ets1


Anatomical context of Ets1

  • Overexpression of Ets-1 in cultured mesangial cells prevented transforming growth factor (TGF)-beta-induced inhibition of DNA-binding activity and TGF-beta-induced type I collagen production [14].
  • In conclusion, hepatocyte PAI-1 expression is flow sensitive and transcriptionally regulated by shear stress via cooperative interactions between Sp1 and Ets-1 [10].
  • Furthermore, we find that expression of dominant negative Ets1 (N70-Ets1) inhibits both the beta-neuregulin and autocrine survival of Schwann cells [15].
  • The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis [1].
  • For clarifying the significance of Ets-1 in ARF, a rat ARF model in vivo and LLC-PK1 cells as an in vitro model were used [2].

Associations of Ets1 with chemical compounds

  • The IL-1beta-caused increase in DNA binding of both NF-kappaB and Ets-1 immunopositive complexes was substantially suppressed by dexamethasone as shown by EMSA [16].
  • 1) Purified p54 is capable of undergoing endogenous phosphorylation in the presence of [gamma-32P]ATP producing a 32P-labeled pp54 polypeptide which is specifically immunoprecipitated by TBR-sera and contains only phosphotyrosine [17].
  • Transcriptional synergy was observed between the proximal VDRE and adjacent EBS as was the attendant formation of a ternary complex between vitamin D receptor- retinoid X receptor (VDR. RXR) and Ets-1 [18].
  • Hydrogen peroxide (H2O2) at nanomolar concentrations stimulated levels of Ets-1 and increased PDGF-Ralpha transcription and mRNA expression without affecting Sp1 expression [19].
  • The current study demonstrates that overexpression of the dominant negative form of JNK1 or p54 JNK2/SAPKbeta reduces Cox-2 expression and PGE2 production stimulated by IL-1beta [20].

Physical interactions of Ets1

  • Electrophoretic mobility shift assays revealed that Ets-1 interacts selectively with the -1350GGAA-1347 Ets element in the p21WAF1/Cip1 promoter [21].
  • A gel shift assay demonstrated that Ets-1 binds to the ets-1 binding site of the cyclin D1 promoter in the ischemia-reperfusion condition [2].

Regulatory relationships of Ets1


Other interactions of Ets1

  • In addition, exogenous Ets-1 abolished TGF-beta-induced collagen gel contraction [14].
  • CONCLUSIONS: The Ets-1 transcriptional factor may participate in IL-1beta-mediated MMP-9 expression in tubulointerstitial cells [25].
  • In contrast, the -1577GGAT-1574 motif mediates basal but not Ets-1 activation of the p21WAF1/Cip1 promoter [21].
  • We confirm that Ets-1 or a related Ets factor is the nuclear target of the Ras pathway leading to activation of the rPRL promoter and demonstrate that Elk-1 and Net do not mediate the Ras response [11].
  • Using a series of site-specific mutations and deletions of the proximal rPRL promoter we have mapped the major Ras/Raf response element (RRE) to a composite Ets-1/GHF-1 binding site located between positions -217 and -190 [11].

Analytical, diagnostic and therapeutic context of Ets1


  1. The transcription factors hypoxia-inducible factor 1alpha and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis. Peters, C.L., Morris, C.J., Mapp, P.I., Blake, D.R., Lewis, C.E., Winrow, V.R. Arthritis Rheum. (2004) [Pubmed]
  2. Expression and function of Ets-1 during experimental acute renal failure in rats. Tanaka, H., Terada, Y., Kobayashi, T., Okado, T., Inoshita, S., Kuwahara, M., Seth, A., Sato, Y., Sasaki, S. J. Am. Soc. Nephrol. (2004) [Pubmed]
  3. Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA. Bellacosa, A., Datta, K., Bear, S.E., Patriotis, C., Lazo, P.A., Copeland, N.G., Jenkins, N.A., Tsichlis, P.N. J. Virol. (1994) [Pubmed]
  4. Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis. Raffetseder, U., Wernert, N., Ostendorf, T., van Roeyen, C., Rauen, T., Behrens, P., Floege, J., Mertens, P.R. Kidney Int. (2004) [Pubmed]
  5. Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62. Buss, F., Stewart, M. J. Cell Biol. (1995) [Pubmed]
  6. Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression. Bradford, A.P., Wasylyk, C., Wasylyk, B., Gutierrez-Hartmann, A. Mol. Cell. Biol. (1997) [Pubmed]
  7. Precise alignment of sites required for mu enhancer activation in B cells. Nikolajczyk, B.S., Nelsen, B., Sen, R. Mol. Cell. Biol. (1996) [Pubmed]
  8. Regulated expression of the ets-1 transcription factor in vascular smooth muscle cells in vivo and in vitro. Hultgårdh-Nilsson, A., Cercek, B., Wang, J.W., Naito, S., Lövdahl, C., Sharifi, B., Forrester, J.S., Fagin, J.A. Circ. Res. (1996) [Pubmed]
  9. Inactivation of Ets 1 transcription factor by a specific decoy strategy reduces rat C6 glioma cell proliferation and mmp-9 expression. Sahin, A., Velten, M., Pietsch, T., Knuefermann, P., Okuducu, A.F., Hahne, J.C., Wernert, N. Int. J. Mol. Med. (2005) [Pubmed]
  10. Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription. Nakatsuka, H., Sokabe, T., Yamamoto, K., Sato, Y., Hatakeyama, K., Kamiya, A., Ando, J. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  11. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. Bradford, A.P., Conrad, K.E., Tran, P.H., Ostrowski, M.C., Gutierrez-Hartmann, A. J. Biol. Chem. (1996) [Pubmed]
  12. A composite Ets/Pit-1 binding site in the prolactin gene can mediate transcriptional responses to multiple signal transduction pathways. Howard, P.W., Maurer, R.A. J. Biol. Chem. (1995) [Pubmed]
  13. The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter. Bradford, A.P., Brodsky, K.S., Diamond, S.E., Kuhn, L.C., Liu, Y., Gutierrez-Hartmann, A. J. Biol. Chem. (2000) [Pubmed]
  14. Transcription factor Ets-1 is essential for mesangial matrix remodeling. Mizui, M., Isaka, Y., Takabatake, Y., Sato, Y., Kawachi, H., Shimizu, F., Takahara, S., Ito, T., Imai, E. Kidney Int. (2006) [Pubmed]
  15. beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors. Parkinson, D.B., Langner, K., Namini, S.S., Jessen, K.R., Mirsky, R. Mol. Cell. Neurosci. (2002) [Pubmed]
  16. Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors. Eberhardt, W., Schulze, M., Engels, C., Klasmeier, E., Pfeilschifter, J. Mol. Endocrinol. (2002) [Pubmed]
  17. Purification of a tyrosine-specific protein kinase from Rous sarcoma virus-induced rat tumor. Blithe, D.L., Richert, N.D., Pastan, I.H. J. Biol. Chem. (1982) [Pubmed]
  18. Regulation of rat cytochrome P450C24 (CYP24) gene expression. Evidence for functional cooperation of Ras-activated Ets transcription factors with the vitamin D receptor in 1,25-dihydroxyvitamin D(3)-mediated induction. Dwivedi, P.P., Omdahl, J.L., Kola, I., Hume, D.A., May, B.K. J. Biol. Chem. (2000) [Pubmed]
  19. Peroxide-inducible Ets-1 mediates platelet-derived growth factor receptor-alpha gene transcription in vascular smooth muscle cells. Bonello, M.R., Bobryshev, Y.V., Khachigian, L.M. Am. J. Pathol. (2005) [Pubmed]
  20. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan, Z., Buckman, S.Y., Miller, B.W., Springer, L.D., Morrison, A.R. J. Biol. Chem. (1998) [Pubmed]
  21. Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter. Zhang, C., Kavurma, M.M., Lai, A., Khachigian, L.M. J. Biol. Chem. (2003) [Pubmed]
  22. Differential roles of ICAM-1 and E-selectin in polymorphonuclear leukocyte-induced angiogenesis. Yasuda, M., Shimizu, S., Ohhinata, K., Naito, S., Tokuyama, S., Mori, Y., Kiuchi, Y., Yamamoto, T. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  23. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. Naito, S., Shimizu, S., Maeda, S., Wang, J., Paul, R., Fagin, J.A. Am. J. Physiol. (1998) [Pubmed]
  24. Expression of Ets-1 transcription factor in relation to angiogenesis in the healing process of gastric ulcer. Ito, M., Nakayama, T., Naito, S., Matsuu, M., Shichijo, K., Sekine, I. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  25. Expression of matrix metalloproteinase-9 associated with ets-1 proto-oncogene in rat tubulointerstitial cells. Naito, T., Tanihata, Y., Nishimura, H., Tanaka, T., Higuchi, C., Taguchi, T., Sanaka, T. Nephrol. Dial. Transplant. (2005) [Pubmed]
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