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Gene Review

Npr1  -  natriuretic peptide receptor 1

Rattus norvegicus

Synonyms: ANP-A, ANPR-A, Anpra, Atrial natriuretic peptide receptor 1, Atrial natriuretic peptide receptor type A, ...
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Disease relevance of Npr1


Psychiatry related information on Npr1

  • In addition, using affinity cross-linking studies we have observed that water deprivation increases the expression of the 67-kDa NPR-C-like protein, and HS-142, which binds to NPR-A and the 77-kDa NPR-C-like but not the 67-kDa protein, reduced ligand internalization without affecting cAMP inhibition by ANP(1-28) [5].

High impact information on Npr1


Chemical compound and disease context of Npr1


Biological context of Npr1


Anatomical context of Npr1


Associations of Npr1 with chemical compounds


Physical interactions of Npr1

  • We have previously demonstrated that atrial natriuretic factor (ANF) binding consistent with the NPR-A receptor is significantly increased in FRTL-5 cells cultured in the presence of TSH [19].
  • We found that NPR-A showed a lower maximal binding capacity (B(max)) and higher affinity in SHR than in WKY rats both in the olfactory bulb and hypothalamus [20].

Regulatory relationships of Npr1


Other interactions of Npr1

  • Previous reports have shown that pressor hormones inhibit natriuretic peptide receptors NPR-A or NPR-B in a variety of different cell types [17].
  • Previously, we showed that increased extracellular tonicity promotes increased type A natriuretic peptide receptor (NPR-A) expression through a p38 MAPKbeta pathway in inner medullary collecting duct cells [11].
  • ANP (10(-9) and 3.10(-9)), which binds to NPR-A and NPR-C, dilated preglomerular vessels and constricted efferent arterioles similarly to that found in previous studies [22].
  • Our results indicate that ANP dilates preglomerular vessels and constricts efferent arterioles through NPR-A, both responses being antagonized by A71915 with different potencies [22].
  • We have shown in previous studies that high extracellular tonicity is associated with increased expression of the type A natriuretic peptide receptor (NPR-A) and reduced expression of the endothelial NO synthase (eNOS) gene in cultured rat inner-medullary collecting duct cells [21].

Analytical, diagnostic and therapeutic context of Npr1


  1. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Christoffersen, T.E., Aplin, M., Strom, C.C., Sheikh, S.P., Skott, O., Busk, P.K., Haunso, S., Nielsen, L.B. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  2. A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney. Woodard, G.E., Zhao, J., Rosado, J.A., Brown, J. Peptides (2002) [Pubmed]
  3. Renal effects of high-dose natriuretic peptide receptor blockade in rats with congestive heart failure. Zhang, P.L., Mackenzie, H.S., Totsune, K., Troy, J.L., Brenner, B.M. Circ. Res. (1995) [Pubmed]
  4. Renal effects of natriuretic peptide receptor blockade in cirrhotic rats with ascites. Angeli, P., Jiménez, W., Arroyo, V., Mackenzie, H.S., Zhang, P.L., Clària, J., Rivera, F., Brenner, B.M., Rodés, J. Hepatology (1994) [Pubmed]
  5. Water deprivation enhances the inhibitory effect of natriuretic peptides on cAMP synthesis in rat renal glomeruli. Woodard, G.E., Li, X., Rosado, J.A. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  6. Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat. Brown, L.A., Nunez, D.J., Wilkins, M.R. J. Clin. Invest. (1993) [Pubmed]
  7. Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. Potter, L.R., Hunter, T. Mol. Cell. Biol. (1998) [Pubmed]
  8. Gene expression of natriuretic peptide receptors in myocardial cells. Lin, X., Hänze, J., Heese, F., Sodmann, R., Lang, R.E. Circ. Res. (1995) [Pubmed]
  9. Altered expression of vascular natriuretic peptide receptors in experimental hypertensive rats. Lee, J., Kim, S., Jung, M., Oh, Y., Kim, S.W. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  10. Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration. Yasunari, K., Kohno, M., Kano, H., Yokokawa, K., Horio, T., Yoshikawa, J. Hypertension (1996) [Pubmed]
  11. Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor. Chen, S., Cao, L., Intengan, H.D., Humphreys, M., Gardner, D.G. J. Biol. Chem. (2002) [Pubmed]
  12. Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats. Nagase, M., Katafuchi, T., Hirose, S., Fujita, T. J. Hypertens. (1997) [Pubmed]
  13. Patterning of renal cGMP production by the natriuretic peptide receptor type A and blood pressure in spontaneously hypertensive rats. Woodard, G.E., Zhao, J., Rosado, J.A., Brown, J. Regul. Pept. (2004) [Pubmed]
  14. Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor. Fernández, B.E., Correa, A.H., Choi, M.R. Regul. Pept. (2005) [Pubmed]
  15. Subtype switching of natriuretic peptide receptors in rat chondrocytes during in vitro culture. Hagiwara, H., Sakaguchi, H., Lodhi, K.M., Suda, K., Hirose, S. J. Biochem. (1994) [Pubmed]
  16. Natriuretic peptide receptors in the fetal rat. Brown, J., Zuo, Z. Am. J. Physiol. (1995) [Pubmed]
  17. Vasopressin-dependent inhibition of the C-type natriuretic peptide receptor, NPR-B/GC-B, requires elevated intracellular calcium concentrations. Abbey, S.E., Potter, L.R. J. Biol. Chem. (2002) [Pubmed]
  18. Regulation of natriuretic peptide receptor A and B expression by transforming growth factor-beta 1 in cultured aortic smooth muscle cells. Fujio, N., Gossard, F., Bayard, F., Tremblay, J. Hypertension (1994) [Pubmed]
  19. Regulation of natriuretic peptide receptors by thyrotropin in FRTL-5 rat thyroid cells: evidence for nonguanylate cyclase atrial natriuretic factor-binding sites in cells lacking the natriuretic peptide receptor C. Sellitti, D.F., Doi, S.Q. Endocrinology (1999) [Pubmed]
  20. Differences between natriuretic peptide receptors in the olfactory bulb and hypothalamus from spontaneously hypertensive and normotensive rat brain. Woodard, G.E., Zhao, J., Rosado, J.A., Brown, J. Neurosci. Res. (2003) [Pubmed]
  21. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells. Ye, Q., Chen, S., Gardner, D.G. Hypertension (2003) [Pubmed]
  22. Natriuretic peptide receptors mediate different responses in rat renal microvessels. Endlich, K., Steinhausen, M. Kidney Int. (1997) [Pubmed]
  23. The primary structure of the rat guanylyl cyclase A/atrial natriuretic peptide receptor gene. Yamaguchi, M., Rutledge, L.J., Garbers, D.L. J. Biol. Chem. (1990) [Pubmed]
  24. Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells. Hutchinson, H.G., Trindade, P.T., Cunanan, D.B., Wu, C.F., Pratt, R.E. Cardiovasc. Res. (1997) [Pubmed]
  25. Localization of natriuretic peptide-activated guanylate cyclase mRNAs in the rat brain. Herman, J.P., Dolgas, C.M., Rucker, D., Langub, M.C. J. Comp. Neurol. (1996) [Pubmed]
  26. Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B. Langenickel, T., Buttgereit, J., Pagel, I., Dietz, R., Willenbrock, R., Bader, M. Hypertension (2004) [Pubmed]
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