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Gene Review

NELFB  -  negative elongation factor complex member B

Homo sapiens

Synonyms: COBRA1, Cofactor of BRCA1, KIAA1182, NELF-B, Negative elongation factor B
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Disease relevance of RP13-122B23.3


High impact information on RP13-122B23.3


Chemical compound and disease context of RP13-122B23.3


Biological context of RP13-122B23.3


Anatomical context of RP13-122B23.3

  • In this study, we demonstrate that COBRA1 mRNA was differentially expressed in breast cancer cell lines by semi-quantitative reverse transcription-polymerase chain PCR (RT-PCR) [11].
  • Treatment of human breast cancer and brain tumor cells with COBRA-1 caused destruction of microtubule organization and apoptosis [12].
  • RESULTS: Surgeons at 3 institutions placed the Cobra catheter in patients undergoing coronary artery bypass grafting (n = 13), valve (n = 3), and combined valve-bypass (n = 4) operations [3].
  • Getting the tube in the oesophagus and oxygen in the trachea: preliminary results with the new supraglottic device (Cobra) in 28 anaesthetised patients [13].
  • OBJECTIVES: In animals the Cardeon Cobra catheter (Cardeon Corp, Cupertino, Calif) allows independent control of aortic arch and descending aortic temperatures and profoundly reduces cerebral embolization during bypass [3].

Associations of RP13-122B23.3 with chemical compounds

  • 1. Cobra cystatin strongly inhibits cysteine proteinases of the papain family, but not calpain [14].
  • We describe a functional assay which is based on the interaction of factor B from various animal species with Cobra Venom Factor, the snake C3b-analog [15].
  • Our aim was to evaluate the performance of the Cobra Perilaryngeal Airway in a cohort study and in a randomised, controlled, crossover comparison study with the Classic Laryngeal Mask Airway [16].
  • The sensitivity and specificity of the four ELISAs were tested with purified antigens and EDTA-plasma or Cobra venom factor-activated EGTA-plasma samples as a source of C3a and C5a [17].
  • Complete amino acid sequence of an acidic, cardiotoxic phospholipase A2 from the venom of Ophiophagus hannah (King Cobra): a novel cobra venom enzyme with "pancreatic loop" [18].

Physical interactions of RP13-122B23.3


Regulatory relationships of RP13-122B23.3


Other interactions of RP13-122B23.3


Analytical, diagnostic and therapeutic context of RP13-122B23.3


  1. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Narita, T., Yamaguchi, Y., Yano, K., Sugimoto, S., Chanarat, S., Wada, T., Kim, D.K., Hasegawa, J., Omori, M., Inukai, N., Endoh, M., Yamada, T., Handa, H. Mol. Cell. Biol. (2003) [Pubmed]
  2. Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas. McChesney, P.A., Aiyar, S.E., Lee, O.J., Zaika, A., Moskaluk, C., Li, R., El-Rifai, W. Cancer Res. (2006) [Pubmed]
  3. Effectiveness of the Cobra aortic catheter for dual-temperature management during adult cardiac surgery. Cook, D.J., Orszulak, T.A., Zehr, K.J., Nussmeier, N.A., Livesay, J.J., Hammon, J.W., Chen, X. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  4. Characterization of phospholipase A2 (PLA2) from Taiwan Cobra: isoenzymes and their site-directed mutants. Pan, F.M., Chao, S.C., Wu, S.H., Chang, W.C., Chiou, S.H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Aiyar, S.E., Sun, J.L., Blair, A.L., Moskaluk, C.A., Lu, Y.Z., Ye, Q.N., Yamaguchi, Y., Mukherjee, A., Ren, D.M., Handa, H., Li, R. Genes Dev. (2004) [Pubmed]
  6. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. Ye, Q., Hu, Y.F., Zhong, H., Nye, A.C., Belmont, A.S., Li, R. J. Cell Biol. (2001) [Pubmed]
  7. The possible role of serum complement system in the formal pathogenesis of acute pancreatitis II. Cobra venom factor pancreatitis--sodiumtaurocholate and deoxycholate pancreatitis. Seelig, R., Seelig, H.P. Acta hepato-gastroenterologica. (1975) [Pubmed]
  8. COBRA1 inhibits AP-1 transcriptional activity in transfected cells. Zhong, H., Zhu, J., Zhang, H., Ding, L., Sun, Y., Huang, C., Ye, Q. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  9. The complete amino acid sequence of a cardiotoxin from the venom of Naja naja (Cambodian Cobra). Fryklund, L., Eaker, D. Biochemistry (1975) [Pubmed]
  10. COBRA-1, a rationally-designed epoxy-THF containing compound with potent tubulin depolymerizing activity as a novel anticancer agent. Jan, S.T., Mao, C., Vassilev, A.O., Navara, C.S., Uckun, F.M. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
  11. Characterization of COBRA1 in human breast cancer cell lines using a new polyclonal antibody against COBRA1. Zhu, J., Song, S., Jiang, Z., Yan, J., Lu, Q., Huang, C., Ye, Q. IUBMB Life (2004) [Pubmed]
  12. Rationally designed anti-mitotic agents with pro-apoptotic activity. Uckun, F.M. Curr. Pharm. Des. (2001) [Pubmed]
  13. Getting the tube in the oesophagus and oxygen in the trachea: preliminary results with the new supraglottic device (Cobra) in 28 anaesthetised patients. Agrò, F., Barzoi, G., Carassiti, M., Gallì, B. Anaesthesia. (2003) [Pubmed]
  14. Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom. Brillard-Bourdet, M., Nguyên, V., Ferrer-di Martino, M., Gauthier, F., Moreau, T. Biochem. J. (1998) [Pubmed]
  15. An assay for complement factor B in species at different levels of evolution. Jensen, L.B., Koch, C. Dev. Comp. Immunol. (1991) [Pubmed]
  16. An evaluation of the Cobra Perilaryngeal Airway: study halted after two cases of pulmonary aspiration. Cook, T.M., Lowe, J.M. Anaesthesia. (2005) [Pubmed]
  17. Detection of native human complement components C3 and C5 and their primary activation peptides C3a and C5a (anaphylatoxic peptides) by ELISAs with monoclonal antibodies. Klos, A., Ihrig, V., Messner, M., Grabbe, J., Bitter-Suermann, D. J. Immunol. Methods (1988) [Pubmed]
  18. Complete amino acid sequence of an acidic, cardiotoxic phospholipase A2 from the venom of Ophiophagus hannah (King Cobra): a novel cobra venom enzyme with "pancreatic loop". Huang, M.Z., Gopalakrishnakone, P., Chung, M.C., Kini, R.M. Arch. Biochem. Biophys. (1997) [Pubmed]
  19. Surgical radiofrequency ablation of both atria for atrial fibrillation: results of a multicenter trial. Raman, J., Ishikawa, S., Storer, M.M., Power, J.M. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  20. Percutaneous angioplasty of stenosed gastroepiploic artery grafts. Isshiki, T., Yamaguchi, T., Tamura, T., Saeki, F., Furuta, Y., Ikari, Y., Chiku, N., Suma, H. J. Am. Coll. Cardiol. (1993) [Pubmed]
  21. Comparison of three disposable extraglottic airway devices in spontaneously breathing adults: the LMA-Unique, the Soft Seal laryngeal mask, and the Cobra perilaryngeal airway. van Zundert, A., Al-Shaikh, B., Brimacombe, J., Koster, J., Koning, D., Mortier, E.P. Anesthesiology (2006) [Pubmed]
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