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Gene Review

GPLD1  -  glycosylphosphatidylinositol specific...

Homo sapiens

Synonyms: GPI-PLD, GPI-specific phospholipase D, GPIPLD, GPIPLDM, Glycoprotein phospholipase D, ...
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Disease relevance of GPLD1


High impact information on GPLD1


Biological context of GPLD1


Anatomical context of GPLD1


Associations of GPLD1 with chemical compounds

  • GPI-PLD binding to heparan sulphate proteoglycan was determined in the absence or presence of heparan sulphate or heparin [13].
  • Further characterization of the GPI-PLD-containing lipoproteins by gel-filtration chromatography and nondenaturing polyacrylamide and agarose gel electrophoresis revealed that these apoA-I-containing particles/complexes were small (8 nm) and migrated with pre-beta particles on agarose electrophoresis [15].
  • To determine the distribution of GPI-PLD among lipoproteins and characterize the GPI-PLD-containing lipoproteins in human plasma, we used dextran sulfate and immunoaffinity chromatography to isolate apolipoprotein-specific lipoproteins [16].
  • Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte- macrophage cell line RAW 264.7 [17].
  • The half-life of GPI-PLD mRNA was not affected by LPS, or decreased slightly with H(2)O(2), indicating that the reduction in GPI-PLD mRNA is due primarily to transcriptional regulation [17].

Other interactions of GPLD1


Analytical, diagnostic and therapeutic context of GPLD1

  • Immunoprecipitation of GPI-PLD with a monoclonal antibody to GPI-PLD co-precipitated apoA-I and apoA-IV but little or no apoA-II, apoC-II, apoC-III, apoD, or apoE [15].
  • We have therefore developed a semi-quantitative RT-PCR method to measure mRNA expression of all known GPI-PLD isoforms in cells and tissues [2].
  • Further characterization of the GPI-PLD-containing lipoproteins by gel filtration chromatography, nondenaturing poly-acrylamide and agarose gel electrophoresis revealed that GPI-PLD was restricted to an apolipoprotein AI-containing particle or complex that was small (apparent mean Mw of 140 kDa) and distinct from the bulk of HDL [16].
  • METHODS AND RESULTS: Immunohistochemistry using human GPI-PLD-specific rabbit polyclonal antiserum was performed on a total of 83 nonatherosclerotic and atherosclerotic human coronary arteries from 23 patients [14].
  • In cases of systemic inflammatory response syndrome, sepsis, and septic shock, the activity of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in serum amounts to 20 to 25% of the activity found in a healthy control group [19].


  1. Effect of glycosylphosphatidylinositol specific phospholipase D gene expression levels on complement mediated killing of leukemic cells in patients with chronic myeloid leukemia. Jian-Hua, T., Xiao-Jie, Z., Yi-Dan, W., Wen-Kai, L., Wang-Jiao, H., Cheng-Hong, W., Gui-Yuan, L. Clin. Chim. Acta (2005) [Pubmed]
  2. GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy. Xiaotong, H., Hannocks, M.J., Hampson, I., Brunner, G. Clin. Exp. Metastasis (2002) [Pubmed]
  3. Immunolocalization of a glycosylphosphatidylinositol-specific phospholipase D in mast cells found in normal tissue and neurofibromatosis lesions. Metz, C.N., Thomas, P., Davitz, M.A. Am. J. Pathol. (1992) [Pubmed]
  4. Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study. Chalasani, N., Vuppalanchi, R., Raikwar, N.S., Deeg, M.A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  5. Altered oxygen tension modulates cytokine-induced signal transduction in polymorphonuclear leukocytes: regulation of the GPLD pathway. Derevianko, A., Graeber, T., D'Amico, R., Simms, H.H. Shock (1996) [Pubmed]
  6. An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures. Brunner, G., Metz, C.N., Nguyen, H., Gabrilove, J., Patel, S.R., Davitz, M.A., Rifkin, D.B., Wilson, E.L. Blood (1994) [Pubmed]
  7. Structural features of GPI-specific phospholipase D revealed by proteolytic fragmentation and Ca2+ binding studies. Li, J.Y., Hollfelder, K., Huang, K.S., Low, M.G. J. Biol. Chem. (1994) [Pubmed]
  8. Production of the glycosylphosphatidylinositol-specific phospholipase D by the islets of Langerhans. Metz, C.N., Zhang, Y.Y., Guo, Y., Tsang, T.C., Kochan, J.P., Altszuler, N., Davitz, M.A. J. Biol. Chem. (1991) [Pubmed]
  9. Phosphorylation decreases trypsin activation and apolipoprotein al binding to glycosylphosphatidylinositol-specific phospholipase D. Deeg, M.A., Bowen, R.F. Biochem. Cell Biol. (2002) [Pubmed]
  10. Insulin resistance is associated with increased serum levels of glycosylphosphatidylinositol-specific phospholipase D. Kurtz, T.A., Fineberg, N.S., Considine, R.V., Deeg, M.A. Metab. Clin. Exp. (2004) [Pubmed]
  11. Peaks of linkage are localized by a BAC/PAC contig of the 6p reading disability locus. Ahn, J., Won, T.W., Zia, A., Reutter, H., Kaplan, D.E., Sparks, R., Gruen, J.R. Genomics (2001) [Pubmed]
  12. Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene. Schofield, J.N., Rademacher, T.W. Biochim. Biophys. Acta (2000) [Pubmed]
  13. Glycosylphosphatidylinositol-specific phospholipase D immunoreactivity is present in islet amyloid in type 2 diabetes. Larson, D.M., Kennedy, M.A., Bowen, R.F., Verchere, C.B., Deeg, M.A. J. Pathol. (2004) [Pubmed]
  14. Glycosylphosphatidylinositol-specific phospholipase D is expressed by macrophages in human atherosclerosis and colocalizes with oxidation epitopes. O'Brien, K.D., Pineda, C., Chiu, W.S., Bowen, R., Deeg, M.A. Circulation (1999) [Pubmed]
  15. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. Deeg, M.A., Bierman, E.L., Cheung, M.C. J. Lipid Res. (2001) [Pubmed]
  16. GPI-specific phospholipase D as an apolipoprotein. Deeg, M.A. Braz. J. Med. Biol. Res. (1994) [Pubmed]
  17. Down-regulation of glycosylphosphatidylinositol-specific phospholipase D induced by lipopolysaccharide and oxidative stress in the murine monocyte- macrophage cell line RAW 264.7. Du, X., Low, M.G. Infect. Immun. (2001) [Pubmed]
  18. Characterization of primate trypanosome lytic factors. Lugli, E.B., Pouliot, M., Portela, M.d.e.l. .P., Loomis, M.R., Raper, J. Mol. Biochem. Parasitol. (2004) [Pubmed]
  19. Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme? Rhode, H., Lopatta, E., Schulze, M., Pascual, C., Schulze, H.P., Schubert, K., Schubert, H., Reinhart, K., Horn, A. Clin. Chim. Acta (1999) [Pubmed]
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