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MeSH Review

Spinothalamic Tracts

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Disease relevance of Spinothalamic Tracts


Psychiatry related information on Spinothalamic Tracts


High impact information on Spinothalamic Tracts


Chemical compound and disease context of Spinothalamic Tracts

  • We investigated the role of mechanosensitive spinothalamic tract (STT) neurons in mediating 1) the itch evoked by intradermal injection of histamine, 2) the enhanced sense of itch evoked by innocuous stroking (alloknesis), and 3) the enhanced pain evoked by punctate stimulation (hyperalgesia) of the skin surrounding the injection site [9].

Biological context of Spinothalamic Tracts


Anatomical context of Spinothalamic Tracts


Associations of Spinothalamic Tracts with chemical compounds


Gene context of Spinothalamic Tracts


Analytical, diagnostic and therapeutic context of Spinothalamic Tracts


  1. Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. Zou, X., Lin, Q., Willis, W.D. J. Neurosci. (2000) [Pubmed]
  2. Pain-related somatosensory evoked potentials can quantitatively evaluate hypalgesia in Wallenberg's syndrome. Kanda, M., Mima, T., Xu, X., Fujiwara, N., Shindo, K., Nagamine, T., Ikeda, A., Shibasaki, H. Acta neurologica Scandinavica. (1996) [Pubmed]
  3. The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad. Engel, J.P., Madigan, T.C., Peterson, G.M. J. Virol. (1997) [Pubmed]
  4. Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Andrew, D., Craig, A.D. Nat. Neurosci. (2001) [Pubmed]
  5. Mechanisms of cardiac pain. Foreman, R.D. Annu. Rev. Physiol. (1999) [Pubmed]
  6. A visceral pain pathway in the dorsal column of the spinal cord. Willis, W.D., Al-Chaer, E.D., Quast, M.J., Westlund, K.N. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferents. Naim, M., Spike, R.C., Watt, C., Shehab, S.A., Todd, A.J. J. Neurosci. (1997) [Pubmed]
  8. Possible role of protein kinase C in the sensitization of primate spinothalamic tract neurons. Lin, Q., Peng, Y.B., Willis, W.D. J. Neurosci. (1996) [Pubmed]
  9. Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli. Simone, D.A., Zhang, X., Li, J., Zhang, J.M., Honda, C.N., LaMotte, R.H., Giesler, G.J. J. Neurophysiol. (2004) [Pubmed]
  10. Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. Zou, X., Lin, Q., Willis, W.D. Neuroscience (2002) [Pubmed]
  11. Upregulation of the phosphorylated form of CREB in spinothalamic tract cells following spinal cord injury: relation to central neuropathic pain. Crown, E.D., Ye, Z., Johnson, K.M., Xu, G.Y., McAdoo, D.J., Westlund, K.N., Hulsebosch, C.E. Neurosci. Lett. (2005) [Pubmed]
  12. Effects of iontophoretically released amino acids and amines on primate spinothalamic tract cells. Willcockson, W.S., Chung, J.M., Hori, Y., Lee, K.H., Willis, W.D. J. Neurosci. (1984) [Pubmed]
  13. Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine. Jordan, L.M., Kenshalo, D.R., Martin, R.F., Haber, L.H., Willis, W.D. Pain (1978) [Pubmed]
  14. Inhibition of rat spinothalamic tract neuronal responses to noxious skin heating by stimulation in midbrain periaqueductal gray or lateral reticular formation. Carstens, E. Pain (1988) [Pubmed]
  15. Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat. Marshall, G.E., Shehab, S.A., Spike, R.C., Todd, A.J. Neuroscience (1996) [Pubmed]
  16. Enhanced responses of spinothalamic tract neurons to excitatory amino acids accompany capsaicin-induced sensitization in the monkey. Dougherty, P.M., Willis, W.D. J. Neurosci. (1992) [Pubmed]
  17. The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. Dougherty, P.M., Palecek, J., Paleckova, V., Sorkin, L.S., Willis, W.D. J. Neurosci. (1992) [Pubmed]
  18. Ultrastructural localization and biochemical features of immunoreactive LEU-enkephalin in monkey dorsal horn. Aronin, N., DiFiglia, M., Liotta, A.S., Martin, J.B. J. Neurosci. (1981) [Pubmed]
  19. Effects of iontophoretically released peptides on primate spinothalamic tract cells. Willcockson, W.S., Chung, J.M., Hori, Y., Lee, K.H., Willis, W.D. J. Neurosci. (1984) [Pubmed]
  20. Combined application of excitatory amino acids and substance P produces long-lasting changes in responses of primate spinothalamic tract neurons. Dougherty, P.M., Palecek, J., Zorn, S., Willis, W.D. Brain Res. Brain Res. Rev. (1993) [Pubmed]
  21. TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons. Slack, S.E., Grist, J., Mac, Q., McMahon, S.B., Pezet, S. J. Comp. Neurol. (2005) [Pubmed]
  22. Ultrastructural localization of glutamate receptor subunits (NMDAR1, AMPA GluR1 and GluR2/3) and spinothalamic tract cells. Ye, Z., Westlund, K.N. Neuroreport (1996) [Pubmed]
  23. Pain-related somatosensory evoked potentials in syringomyelia. Kakigi, R., Shibasaki, H., Kuroda, Y., Neshige, R., Endo, C., Tabuchi, K., Kishikawa, T. Brain (1991) [Pubmed]
  24. Infusion of substance P or neurokinin A by microdialysis alters responses of primate spinothalamic tract neurons to cutaneous stimuli and to iontophoretically released excitatory amino acids. Dougherty, P.M., Palecek, J., Palecková, V., Willis, W.D. Pain (1995) [Pubmed]
  25. Effects of mechanical and chemical stimulation of fine muscle afferents upon primate spinothalamic tract cells. Foreman, R.D., Schmidt, R.F., Willis, W.D. J. Physiol. (Lond.) (1979) [Pubmed]
  26. Organization of the serotonergic innervation of spinal neurons in rats--I. Neuropeptide coexistence in varicosities innervating some spinothalamic tract neurons but not in those innervating postsynaptic dorsal column neurons. Wu, W., Wessendorf, M.W. Neuroscience (1992) [Pubmed]
  27. Descending adrenergic input to the primate spinal cord and its possible role in modulation of spinothalamic cells. Carlton, S.M., Honda, C.N., Willcockson, W.S., Lacrampe, M., Zhang, D., Denoroy, L., Chung, J.M., Willis, W.D. Brain Res. (1991) [Pubmed]
  28. Stereotactic mesencephalotomy for pain relief. A plea for stereotactic surgery. Amano, K., Kawamura, H., Tanikawa, T., Kawabatake, H., Iseki, H., Taira, T. Stereotactic and functional neurosurgery. (1992) [Pubmed]
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