Gene Review:
Snca - synuclein, alpha (non A4 component of...
Rattus norvegicus
Synonyms:
Alpha-synuclein
Malkiewicz,
Mohammed,
Folkesson,
Winblad,
Szutowski,
Benedikz,
Jensen,
Nielsen,
Jakes,
Dotti,
Goedert,
Rideout,
Dietrich,
Savalle,
Dauer,
Stefanis,
Malatynska,
Pinhasov,
Crooke,
Horowitz,
Brenneman,
Ilyin,
Richter-Landsberg,
Gorath,
Trojanowski,
Lee,
Kitamura,
Ishida,
Takata,
Kakimura,
Mizutani,
Shimohama,
Akaike,
Taniguchi,
- Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS. Li, J.Y., Henning Jensen, P., Dahlström, A. Neuroscience (2002)
- Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Tanaka, Y., Engelender, S., Igarashi, S., Rao, R.K., Wanner, T., Tanzi, R.E., Sawa, A., L Dawson, V., Dawson, T.M., Ross, C.A. Hum. Mol. Genet. (2001)
- Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. Ghee, M., Fournier, A., Mallet, J. J. Neurochem. (2000)
- alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes. Richter-Landsberg, C., Gorath, M., Trojanowski, J.Q., Lee, V.M. J. Neurosci. Res. (2000)
- Ultrastructure of alpha-synuclein-positive aggregations in U373 astrocytoma and rat primary glial cells. Stefanova, N., Emgård, M., Klimaschewski, L., Wenning, G.K., Reindl, M. Neurosci. Lett. (2002)
- Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury. Kholodilov, N.G., Neystat, M., Oo, T.F., Lo, S.E., Larsen, K.E., Sulzer, D., Burke, R.E. J. Neurochem. (1999)
- Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation. Jensen, P.H., Nielsen, M.S., Jakes, R., Dotti, C.G., Goedert, M. J. Biol. Chem. (1998)
- Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Betarbet, R., Sherer, T.B., MacKenzie, G., Garcia-Osuna, M., Panov, A.V., Greenamyre, J.T. Nat. Neurosci. (2000)
- Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression. Kitajka, K., Sinclair, A.J., Weisinger, R.S., Weisinger, H.S., Mathai, M., Jayasooriya, A.P., Halver, J.E., Puskás, L.G. Proc. Natl. Acad. Sci. U.S.A. (2004)
- alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Liang, T., Spence, J., Liu, L., Strother, W.N., Chang, H.W., Ellison, J.A., Lumeng, L., Li, T.K., Foroud, T., Carr, L.G. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. Kim, S.J., Sung, J.Y., Um, J.W., Hattori, N., Mizuno, Y., Tanaka, K., Paik, S.R., Kim, J., Chung, K.C. J. Biol. Chem. (2003)
- Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. Murphy, D.D., Rueter, S.M., Trojanowski, J.Q., Lee, V.M. J. Neurosci. (2000)
- Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo. Forloni, G., Bertani, I., Calella, A.M., Thaler, F., Invernizzi, R. Ann. Neurol. (2000)
- Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Kitamura, Y., Ishida, Y., Takata, K., Kakimura, J., Mizutani, H., Shimohama, S., Akaike, A., Taniguchi, T. Brain Res. (2001)
- Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. Ding, T.T., Lee, S.J., Rochet, J.C., Lansbury, P.T. Biochemistry (2002)
- Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity. Stéphan, A., Davis, S., Salin, H., Dumas, S., Mallet, J., Laroche, S. Hippocampus. (2002)
- Expression of alpha-synuclein in different brain parts of adult and aged rats. Adamczyk, A., Solecka, J., Strosznajder, J.B. J. Physiol. Pharmacol. (2005)
- Polychlorinated biphenyls alter expression of alpha-synuclein, synaptophysin and parkin in the rat brain. Malkiewicz, K., Mohammed, R., Folkesson, R., Winblad, B., Szutowski, M., Benedikz, E. Toxicol. Lett. (2006)
- The induction of amyloid precursor protein and alpha-synuclein in rat hippocampal astrocytes by diethyldithiocarbamate and copper with or without glutathione. Cheng, S.Y., Trombetta, L.D. Toxicol. Lett. (2004)
- alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons. Rideout, H.J., Dietrich, P., Wang, Q., Dauer, W.T., Stefanis, L. J. Biol. Chem. (2004)
- alpha-synuclein overexpression promotes aggregation of mutant huntingtin. Furlong, R.A., Narain, Y., Rankin, J., Wyttenbach, A., Rubinsztein, D.C. Biochem. J. (2000)
- Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons. Rideout, H.J., Dietrich, P., Savalle, M., Dauer, W.T., Stefanis, L. J. Neurochem. (2003)
- Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. Leng, Y., Chuang, D.M. J. Neurosci. (2006)
- Levels of mRNA Coding for alpha-, beta-, and gamma-Synuclein in the Brains of Newborn, Juvenile, and Adult Rats. Malatynska, E., Pinhasov, A., Crooke, J., Horowitz, D., Brenneman, D.E., Ilyin, S.E. J. Mol. Neurosci. (2006)
- Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease. Hashimoto, M., Takenouchi, T., Rockenstein, E., Masliah, E. J. Neurochem. (2003)
- Developmental expression of alpha-synuclein in rat hippocampus and cerebral cortex. Petersen, K., Olesen, O.F., Mikkelsen, J.D. Neuroscience (1999)