Gene Review:
Park2 - parkin RBR E3 ubiquitin protein ligase
Rattus norvegicus
Synonyms:
E3 ubiquitin-protein ligase parkin, Park, Prkn
- Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Dong, Z., Ferger, B., Paterna, J.C., Vogel, D., Furler, S., Osinde, M., Feldon, J., Büeler, H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. Kim, S.J., Sung, J.Y., Um, J.W., Hattori, N., Mizuno, Y., Tanaka, K., Paik, S.R., Kim, J., Chung, K.C. J. Biol. Chem. (2003)
- Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Lo Bianco, C., Schneider, B.L., Bauer, M., Sajadi, A., Brice, A., Iwatsubo, T., Aebischer, P. Proc. Natl. Acad. Sci. U.S.A. (2004)
- A selective N-type Ca(2+)-channel blocker prevents CA1 injury 24 h following severe forebrain ischemia and reduces infarction following focal ischemia. Buchan, A.M., Gertler, S.Z., Li, H., Xue, D., Huang, Z.G., Chaundy, K.E., Barnes, K., Lesiuk, H.J. J. Cereb. Blood Flow Metab. (1994)
- Effects of feeding a "cafeteria" diet on energy balance and diet-induced thermogenesis in four strains of rat. Rothwell, N.J., Saville, M.E., Stock, M.J. J. Nutr. (1982)
- Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Darios, F., Corti, O., Lücking, C.B., Hampe, C., Muriel, M.P., Abbas, N., Gu, W.J., Hirsch, E.C., Rooney, T., Ruberg, M., Brice, A. Hum. Mol. Genet. (2003)
- Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Tanaka, Y., Engelender, S., Igarashi, S., Rao, R.K., Wanner, T., Tanzi, R.E., Sawa, A., L Dawson, V., Dawson, T.M., Ross, C.A. Hum. Mol. Genet. (2001)
- Effect of the neurotoxic dose of methamphetamine on gene expression of parkin and Pael-receptors in rat striatum. Nakahara, T., Kuroki, T., Ohta, E., Kajihata, T., Yamada, H., Yamanaka, M., Hashimoto, K., Tsutsumi, T., Hirano, M., Uchimura, H. Parkinsonism Relat. Disord. (2003)
- Normal sexual development of two strains of rat exposed in utero to low doses of bisphenol A. Tinwell, H., Haseman, J., Lefevre, P.A., Wallis, N., Ashby, J. Toxicol. Sci. (2002)
- Diet and the epidemiology of human breast cancer. Mettlin, C. Cancer (1984)
- Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress. Ledesma, M.D., Galvan, C., Hellias, B., Dotti, C., Jensen, P.H. J. Neurochem. (2002)
- Parkin transcript variants in rat and human brain. Dagata, V., Cavallaro, S. Neurochem. Res. (2004)
- Enhancement of endogenous fibrinolysis does not reduce local fibrin deposition, but modulates inflammation upon intestinal ischemia and reperfusion. Schoots, I.G., Levi, M., van Vliet, A.K., Declerck, P.J., Maas, A.M., van Gulik, T.M. Thromb. Haemost. (2004)
- p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Cho, S.Y., Jeon, J.W., Lee, S.H., Park, S.S. Biochem. J. (2000)
- Acute and chronic haloperidol treatments increase parkin mRNA levels in the rat brain. Nakahara, T., Gotoh, L., Motomura, K., Kawanami, N., Ohta, E., Hirano, M., Uchimura, H. Neurosci. Lett. (2001)
- Distribution of parkin in the adult rat brain. D'Agata, V., Zhao, W., Pascale, A., Zohar, O., Scapagnini, G., Cavallaro, S. Prog. Neuropsychopharmacol. Biol. Psychiatry (2002)
- Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. Ren, Y., Zhao, J., Feng, J. J. Neurosci. (2003)
- Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein. Abumrad, N.A., Park, J.H., Park, C.R. J. Biol. Chem. (1984)
- Protein kinase activities in rat pancreatic islets of Langerhans. Sugden, M.C., Ashcroft, S.J., Sugden, P.H. Biochem. J. (1979)
- Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. Gerner, E.W., Mamont, P.S., Bernhardt, A., Siat, M. Biochem. J. (1986)
- Polychlorinated biphenyls alter expression of alpha-synuclein, synaptophysin and parkin in the rat brain. Malkiewicz, K., Mohammed, R., Folkesson, R., Winblad, B., Szutowski, M., Benedikz, E. Toxicol. Lett. (2006)
- Regional and cellular expression of the parkin gene in the rat cerebral cortex. D'Agata, V., Grimaldi, M., Pascale, A., Cavallaro, S. Eur. J. Neurosci. (2000)
- Cloning and distribution of the rat parkin mRNA. D'Agata, V., Zhao, W., Cavallaro, S. Brain Res. Mol. Brain Res. (2000)
- Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease. Yamada, M., Mizuno, Y., Mochizuki, H. Hum. Gene Ther. (2005)
- Regulation of hippocampal parkin protein by corticosteroids. Horowitz, J.M., Pastor, D.M., Kar, S., Arinsburg, S.A., Hallas, B.H., Torres, G. Neuroreport (2003)