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Chemical Compound Review

alpha-PBN     1-phenyl-N-tert-butyl- methanimine oxide

Synonyms: AC1LCXAE, CHEMBL13210, AG-G-62065, B7263_SIGMA, AC1Q1WHY, ...
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Disease relevance of C-Phenyl-N-tert-butylnitrone


Psychiatry related information on C-Phenyl-N-tert-butylnitrone


High impact information on C-Phenyl-N-tert-butylnitrone


Chemical compound and disease context of C-Phenyl-N-tert-butylnitrone


Biological context of C-Phenyl-N-tert-butylnitrone


Anatomical context of C-Phenyl-N-tert-butylnitrone


Associations of C-Phenyl-N-tert-butylnitrone with other chemical compounds


Gene context of C-Phenyl-N-tert-butylnitrone


Analytical, diagnostic and therapeutic context of C-Phenyl-N-tert-butylnitrone


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  4. Effect of alpha-phenyl-N-tert-butylnitrone on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet. Park, W.S., Chang, Y.S., Lee, M. J. Neurochem. (2000) [Pubmed]
  5. Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. Tomita, H., Kotake, Y., Anderson, R.E. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
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  8. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F., Floyd, R.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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  13. Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia. Rogoza, R.M., Fairfax, D.F., Henry, P., N-Marandi, S., Khan, R.F., Gupta, S.K., Mishra, R.K. Synapse (2004) [Pubmed]
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  15. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. Murphy, M.P., Echtay, K.S., Blaikie, F.H., Asin-Cayuela, J., Cocheme, H.M., Green, K., Buckingham, J.A., Taylor, E.R., Hurrell, F., Hughes, G., Miwa, S., Cooper, C.E., Svistunenko, D.A., Smith, R.A., Brand, M.D. J. Biol. Chem. (2003) [Pubmed]
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  21. Delayed Loss of Cone and Remaining Rod Photoreceptor Cells due to Impairment of Choroidal Circulation after Acute Light Exposure in Rats. Tanito, M., Kaidzu, S., Anderson, R.E. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
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  25. Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons. Mattson, M.P., Lovell, M.A., Furukawa, K., Markesbery, W.R. J. Neurochem. (1995) [Pubmed]
  26. Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase. Komiyama, T., Kikuchi, T., Sugiura, Y. Biochem. Pharmacol. (1982) [Pubmed]
  27. Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins. Tsuji, M., Inanami, O., Kuwabara, M. Neurosci. Lett. (2000) [Pubmed]
  28. Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Siniscalco, D., Fuccio, C., Giordano, C., Ferraraccio, F., Palazzo, E., Luongo, L., Rossi, F., Roth, K.A., Maione, S., de Novellis, V. Pharmacol. Res. (2007) [Pubmed]
  29. The role of heme oxygenase-related carbon monoxide and ventricular fibrillation in ischemic/reperfused hearts. Bak, I., Papp, G., Turoczi, T., Varga, E., Szendrei, L., Vecsernyes, M., Joo, F., Tosaki, A. Free Radic. Biol. Med. (2002) [Pubmed]
  30. Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts. Pieper, G.M., Nilakantan, V., Zhou, X., Khanna, A.K., Johnson, C.P., Roza, A.M., Adams, M.B., Hilton, G., Felix, C.C. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  31. Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver. Xu, D.X., Chen, Y.H., Wang, J.P., Sun, M.F., Wang, H., Wei, L.Z., Wei, W. Toxicol. Sci. (2005) [Pubmed]
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  34. Amelioration of age-related deficits in the stimulation of synapsin phosphorylation. Eckles, K.E., Dudek, E.M., Bickford, P.C., Browning, M.D. Neurobiol. Aging (1997) [Pubmed]
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