Gene Review:
Apaf1 - apoptotic peptidase activating factor 1
Rattus norvegicus
Synonyms:
APAF-1, Apoptotic protease-activating factor 1
- Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. Yakovlev, A.G., Ota, K., Wang, G., Movsesyan, V., Bao, W.L., Yoshihara, K., Faden, A.I. J. Neurosci. (2001)
- Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression. Okouchi, M., Okayama, N., Aw, T.Y. Current neurovascular research. (2005)
- Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia. Cao, G., Luo, Y., Nagayama, T., Pei, W., Stetler, R.A., Graham, S.H., Chen, J. J. Cereb. Blood Flow Metab. (2002)
- Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Yoshida, H., Kong, Y.Y., Yoshida, R., Elia, A.J., Hakem, A., Hakem, R., Penninger, J.M., Mak, T.W. Cell (1998)
- Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex. Freathy, C., Brown, D.G., Roberts, R.A., Cain, K. Hepatology (2000)
- Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Springer, J.E., Azbill, R.D., Knapp, P.E. Nat. Med. (1999)
- Apaf-1 deficiency and neural tube closure defects are found in fog mice. Honarpour, N., Gilbert, S.L., Lahn, B.T., Wang, X., Herz, J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1. Ekshyyan, O., Aw, T.Y. Cell Death Differ. (2005)
- Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. Henshall, D.C., Bonislawski, D.P., Skradski, S.L., Araki, T., Lan, J.Q., Schindler, C.K., Meller, R., Simon, R.P. Cell Death Differ. (2001)
- Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. Chong, Z.Z., Kang, J.Q., Maiese, K. J. Cereb. Blood Flow Metab. (2003)
- Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. Potokar, M., Kreft, M., Chowdhury, H.H., Vardjan, N., Zorec, R. Am. J. Physiol., Cell Physiol. (2006)
- Alteration of apoptotic protease-activating factor-1 (APAF-1)-dependent apoptotic pathway during development of rat brain and liver. Ota, K., Yakovlev, A.G., Itaya, A., Kameoka, M., Tanaka, Y., Yoshihara, K. J. Biochem. (2002)
- Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Lingor, P., Koeberle, P., Kügler, S., Bähr, M. Brain (2005)
- Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Konrad, L., Keilani, M.M., Laible, L., Nottelmann, U., Hofmann, R. Apoptosis (2006)
- Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome. Takatani, T., Takahashi, K., Uozumi, Y., Shikata, E., Yamamoto, Y., Ito, T., Matsuda, T., Schaffer, S.W., Fujio, Y., Azuma, J. Am. J. Physiol., Cell Physiol. (2004)
- Gene expression analysis of the rat testis after treatment with di(2-ethylhexyl) phthalate using cDNA microarray and real-time RT-PCR. Kijima, K., Toyosawa, K., Yasuba, M., Matsuoka, N., Adachi, T., Komiyama, M., Mori, C. Toxicol. Appl. Pharmacol. (2004)
- Regulation of neuronal P53 activity by CXCR 4. Khan, M.Z., Shimizu, S., Patel, J.P., Nelson, A., Le, M.T., Mullen-Przeworski, A., Brandimarti, R., Fatatis, A., Meucci, O. Mol. Cell. Neurosci. (2005)
- Polyamine depletion prevents camptothecin-induced apoptosis by inhibiting the release of cytochrome c. Yuan, Q., Ray, R.M., Johnson, L.R. Am. J. Physiol., Cell Physiol. (2002)
- RNA expression bcl-w, a new related protein Bcl-2 family, and caspase-3 in isolated sertoli cells from pre-pubertal rat testes. Giannattasio, A., Angeletti, G., De Rosa, M., Zarrilli, S., Ambrosino, M., Cimmino, A., Coppola, C., Panza, G., Calafiore, R., Colao, A., Abete, O., Lombardi, G. J. Endocrinol. Invest. (2002)
- A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid. Castro, R.E., Solá, S., Ma, X., Ramalho, R.M., Kren, B.T., Steer, C.J., Rodrigues, C.M. J. Hepatol. (2005)
- Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Matsumori, Y., Northington, F.J., Hong, S.M., Kayama, T., Sheldon, R.A., Vexler, Z.S., Ferriero, D.M., Weinstein, P.R., Liu, J. Stroke (2006)