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Gene Review

AQP8  -  aquaporin 8

Homo sapiens

Synonyms: AQP-8, Aquaporin-8
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Disease relevance of AQP8


High impact information on AQP8


Biological context of AQP8


Anatomical context of AQP8


Associations of AQP8 with chemical compounds


Other interactions of AQP8

  • The roles of AQP-8 and AQP-3 in water absorption remain to be established [14].
  • While the localization of AQP5 in this gland has been verified in several laboratories, there have been differing reports regarding AQP8 localization [15].
  • In the rat PG, AQP8 was invested near intercalated ducts and adjacent acini, whereas NKCC1 localized in the basolateral membranes of acinar cells [15].
  • Thus, in agreement with an earlier report by other investigators (Elkjaer et al., Am J Physiol Renal Physiol 281:F1047-F1057, 2001), we report that AQP8 is expressed in the myoepithelial cells, but not in the acinar cells, of both the rat SMG and PG [15].

Analytical, diagnostic and therapeutic context of AQP8


  1. Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors. Fischer, H., Stenling, R., Rubio, C., Lindblom, A. BMC Physiol. (2001) [Pubmed]
  2. Expression of aquaporin 8 in colonic epithelium with diarrhoea-predominant irritable bowel syndrome. Wang, J.P., Hou, X.H. Chin. Med. J. (2007) [Pubmed]
  3. Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes. Bienert, G.P., M??ller, A.L., Kristiansen, K.A., Schulz, A., M??ller, I.M., Schjoerring, J.K., Jahn, T.P. J. Biol. Chem. (2007) [Pubmed]
  4. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Yang, B., Zhao, D., Solenov, E., Verkman, A.S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  5. Aquaporin homologues in plants and mammals transport ammonia. Jahn, T.P., Møller, A.L., Zeuthen, T., Holm, L.M., Klaerke, D.A., Mohsin, B., Kühlbrandt, W., Schjoerring, J.K. FEBS Lett. (2004) [Pubmed]
  6. Aquaporins (water channels): role in vasopressin-activated water transport. Dibas, A.I., Mia, A.J., Yorio, T. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  7. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. Koyama, N., Ishibashi, K., Kuwahara, M., Inase, N., Ichioka, M., Sasaki, S., Marumo, F. Genomics (1998) [Pubmed]
  8. Triiodothyronine modulates the expression of aquaporin-8 in rat liver mitochondria. Calamita, G., Moreno, M., Ferri, D., Silvestri, E., Roberti, P., Schiavo, L., Gena, P., Svelto, M., Goglia, F. J. Endocrinol. (2007) [Pubmed]
  9. Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12. Viggiano, L., Rocchi, M., Svelto, M., Calamita, G. Cytogenet. Cell Genet. (1999) [Pubmed]
  10. Purification and functional characterization of aquaporin-8. Liu, K., Nagase, H., Huang, C.G., Calamita, G., Agre, P. Biol. Cell (2006) [Pubmed]
  11. Expression and subcellular localization of the AQP8 and AQP1 water channels in the mouse gall-bladder epithelium. Calamita, G., Ferri, D., Bazzini, C., Mazzone, A., Bottà, G., Liquori, G.E., Paulmichl, M., Portincasa, P., Meyer, G., Svelto, M. Biol. Cell (2005) [Pubmed]
  12. Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells. Wang, S., Chen, J., Au, K.T., Ross, M.G. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  13. Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption. Wang, S., Kallichanda, N., Song, W., Ramirez, B.A., Ross, M.G. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  14. Distribution of aquaporins in the colon of Octodon degus, a South American desert rodent. Gallardo, P., Olea, N., Sepúlveda, F.V. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) [Pubmed]
  15. Further evidence for AQP8 expression in the myoepithelium of rat submandibular and parotid glands. Wellner, R.B., Redman, R.S., Swaim, W.D., Baum, B.J. Pflugers Arch. (2006) [Pubmed]
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