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MeSH Review

Colon, Ascending

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Disease relevance of Colon, Ascending


High impact information on Colon, Ascending

  • Of the noncellulose polysaccharides examined, mannose and galactose were protective against cancers in the ascending colon in males (ORs = 0.5 and 0.3, respectively), whereas galactose and uronic acid were protective against cancers in the ascending colon in females (ORs = 0.5) [6].
  • Evidence for size and charge permselectivity of rat ascending colon. Effects of ricinoleate and bile salts on oxalic acid and neutral sugar transport [7].
  • Hydrogen sulfide more significantly inhibited fatty acid oxidation in the rectosigmoid than in the ascending colon (P < 0.02) [8].
  • Lactulose, 10-20 mL three times daily, significantly accelerated mean transit through the ascending colon from 12.9 +/- 3.7 to 7.0 +/- 2.5 hours (n = 11; P less than 0.01) [9].
  • The case of a 61-year-old man who gradually developed similar inflammatory changes in the ascending colon during prolonged intake of a slow-release form of diclofenac is presented, and the literature on nonsteroidal antiinflammatory drug-induced intestinal strictures is briefly reviewed [10].

Chemical compound and disease context of Colon, Ascending


Biological context of Colon, Ascending


Anatomical context of Colon, Ascending


Associations of Colon, Ascending with chemical compounds

  • In contrast, the mucosal addition of 0.1 mM amiloride to ascending colon decreased Vt by only 30% (p less than 0.02) and Isc by 43% (p less than 0.05), but had no significant effect on Rt [23].
  • The site of active intermittent gastrointestinal (GI) bleeding could not be found in a patient until abdominal scintigrams with indium-111-labeled red cells suggested that the bleeding was in the ascending colon [24].
  • In the ascending colon there might be a relationship between specific activity of glutathione S-transferases and age of the patient, activity decreasing with increasing age [25].
  • Cisapride decreased the half-emptying of the caecum and ascending colon from 1.68 +/- 0.4 hours to 0.72 +/- 0.15 hours (P less than 0.05) [26].
  • CONCLUSION: This mesalazine EC gastroresistant tablets release locally active 5-ASA specifically in the ileo-caecal region and the ascending colon [27].

Gene context of Colon, Ascending


Analytical, diagnostic and therapeutic context of Colon, Ascending


  1. A comparison of budesonide and mesalamine for active Crohn's disease. International Budesonide-Mesalamine Study Group. Thomsen, O.O., Cortot, A., Jewell, D., Wright, J.P., Winter, T., Veloso, F.T., Vatn, M., Persson, T., Pettersson, E. N. Engl. J. Med. (1998) [Pubmed]
  2. Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen. Popovich, I.G., Zabezhinski, M.A., Egormin, P.A., Tyndyk, M.L., Anikin, I.V., Spasov, A.A., Semenchenko, A.V., Yashin, A.I., Anisimov, V.N. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  3. The effect of a probiotic drink with Lactobacillus plantarum 299v on the bacterial composition in faeces and mucosal biopsies of rectum and ascending colon. Goossens, D.A., Jonkers, D.M., Russel, M.G., Stobberingh, E.E., Stockbrügger, R.W. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  4. Effect of the addition of Peptostreptococcus productus ATCC35244 on the gastro-intestinal microbiota and its activity, as simulated in an in vitro simulator of the human gastro-intestinal tract. Nollet, L., Vande Velde, I., Verstraete, W. Appl. Microbiol. Biotechnol. (1997) [Pubmed]
  5. In vitro responses of equine colonic arterial and venous rings to adenosine triphosphate. Tetens, J., Venugopal, C.S., Holmes, E.P., Koch, C.E., Hosgood, G., Moore, R.M. Am. J. Vet. Res. (2001) [Pubmed]
  6. Diet and colon cancer: assessment of risk by fiber type and food source. Slattery, M.L., Sorenson, A.W., Mahoney, A.W., French, T.K., Kritchevsky, D., Street, J.C. J. Natl. Cancer Inst. (1988) [Pubmed]
  7. Evidence for size and charge permselectivity of rat ascending colon. Effects of ricinoleate and bile salts on oxalic acid and neutral sugar transport. Kathpalia, S.C., Favus, M.J., Coe, F.L. J. Clin. Invest. (1984) [Pubmed]
  8. Reducing sulfur compounds of the colon impair colonocyte nutrition: implications for ulcerative colitis. Roediger, W.E., Duncan, A., Kapaniris, O., Millard, S. Gastroenterology (1993) [Pubmed]
  9. Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit. Barrow, L., Steed, K.P., Spiller, R.C., Watts, P.J., Melia, C.D., Davies, M.C., Wilson, C.G. Gastroenterology (1992) [Pubmed]
  10. Nonsteroidal antiinflammatory drug-induced colonic strictures: a case report. Huber, T., Ruchti, C., Halter, F. Gastroenterology (1991) [Pubmed]
  11. Oral budesonide is as effective as oral prednisolone in active Crohn's disease. The Global Budesonide Study Group. Campieri, M., Ferguson, A., Doe, W., Persson, T., Nilsson, L.G. Gut (1997) [Pubmed]
  12. Diaphragm disease of the ascending colon. Association with sustained-release diclofenac. Halter, F., Weber, B., Huber, T., Eigenmann, F., Frey, M.P., Ruchti, C. J. Clin. Gastroenterol. (1993) [Pubmed]
  13. Histochemical study of colonic cancer in experimental colitis of rats. Tamaru, T., Kobayashi, H., Kishimoto, S., Kajiyama, G., Shimamoto, F., Brown, W.R. Dig. Dis. Sci. (1993) [Pubmed]
  14. Right-sided ulcerative colitis. Okada, M., Maeda, K., Yao, T., Iwashita, A., Hoshiko, K., Seo, M., Murayama, H., Ohta, K. J. Gastroenterol. (1996) [Pubmed]
  15. Effects of the 21-aminosteroid U-74389G on ischemia and reperfusion injury of the ascending colon in horses. Vatistas, N.J., Snyder, J.R., Hildebrand, S.V., Harmon, F.A., Woliner, M.J., Henry, P., Enos, L.R., Magliano, D., Brown, S.A., Drake, C. Am. J. Vet. Res. (1993) [Pubmed]
  16. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Roediger, W.E. Gut (1980) [Pubmed]
  17. Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study. Cremonini, F., Camilleri, M., McKinzie, S., Carlson, P., Camilleri, C.E., Burton, D., Thomforde, G., Urrutia, R., Zinsmeister, A.R. Am. J. Gastroenterol. (2005) [Pubmed]
  18. A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome. Ohman, L., Isaksson, S., Lundgren, A., Simrén, M., Sjövall, H. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. (2005) [Pubmed]
  19. Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis. Podolsky, D.K., Isselbacher, K.J. Gastroenterology (1984) [Pubmed]
  20. Cisapride accelerates colonic transit in constipated patients with colonic inertia. Krevsky, B., Maurer, A.H., Malmud, L.S., Fisher, R.S. Am. J. Gastroenterol. (1989) [Pubmed]
  21. Malabsorption of zinc in rats with acetic acid-induced enteritis and colitis. Naveh, Y., Lee-Ambrose, L.M., Samuelson, D.A., Cousins, R.J. J. Nutr. (1993) [Pubmed]
  22. Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit. Kirikoshi, H., Katoh, M. Int. J. Oncol. (2002) [Pubmed]
  23. Electrophysiology of the human colon: evidence of segmental heterogeneity. Sandle, G.I., Wills, N.K., Alles, W., Binder, H.J. Gut (1986) [Pubmed]
  24. Scintigraphy with In-111-labeled red cells in intermittent gastrointestinal bleeding. Ferrant, A., Dehasque, N., Leners, N., Meunier, H. J. Nucl. Med. (1980) [Pubmed]
  25. Human intestinal glutathione S-transferases. Peters, W.H., Roelofs, H.M., Nagengast, F.M., van Tongeren, J.H. Biochem. J. (1989) [Pubmed]
  26. The effect of oral cisapride on colonic transit. Krevsky, B., Malmud, L.S., Maurer, A.H., Somers, M.B., Siegel, J.A., Fisher, R.S. Aliment. Pharmacol. Ther. (1987) [Pubmed]
  27. 5-aminosalicylic acid release from a new controlled-release mesalazine formulation during gastrointestinal transit in healthy volunteers. Brunner, M., Lackner, E., Exler, P.S., Fluiter, H.C., Kletter, K., Tschurlovits, M., Dudczak, R., Eichler, H.G., Müller, M. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  28. Neuropeptides in idiopathic chronic constipation (slow transit constipation). Sjölund, K., Fasth, S., Ekman, R., Hultén, L., Jiborn, H., Nordgren, S., Sundler, F. Neurogastroenterol. Motil. (1997) [Pubmed]
  29. Abnormal levels of neuropeptide Y and peptide YY in the colon in irritable bowel syndrome. Simrén, M., Stotzer, P.O., Sjövall, H., Abrahamsson, H., Björnsson, E.S. European journal of gastroenterology & hepatology. (2003) [Pubmed]
  30. Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa. Bergheim, I., Bode, C., Parlesak, A. BMC clinical pharmacology [electronic resource]. (2005) [Pubmed]
  31. CARD15 genotype and phenotype analysis in 55 pediatric patients with Crohn disease from Saxony, Germany. Sun, L., Roesler, J., Rösen-Wolff, A., Winkler, U., Koch, R., Thürigen, A., Henker, J. J. Pediatr. Gastroenterol. Nutr. (2003) [Pubmed]
  32. Effect of liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) instillations on dynamics and function of continent cecal urinary reservoirs. Fowler, J.E., Clayton, M., Mouli, K., Reagan, G. J. Urol. (1987) [Pubmed]
  33. Colonic absorption and bioavailability of the pentapeptide metkephamid in the rat. Langguth, P., Breves, G., Stöckli, A., Merkle, H.P., Wolffram, S. Pharm. Res. (1994) [Pubmed]
  34. Early Candida isolations in febrile patients after abdominal surgery. Rantala, A., Niinikoski, J., Lehtonen, O.P. Scand. J. Infect. Dis. (1993) [Pubmed]
  35. Oral budesonide in the management of Crohn's disease. Hofer, K.N. The Annals of pharmacotherapy. (2003) [Pubmed]
  36. Colonic adenoma detected by positron emission tomography (PET): a case report. Yasuda, S., Shohtsu, A., Tsutsumi, Y. Tokai J. Exp. Clin. Med. (1998) [Pubmed]
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